Basic Information:

  VIRBase ID:  

HHID00096474

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:  MIMAT0005929          AGTRAP:  NM_001040195     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1275	AGTRAP
miRBase Accession/Entrez ID	MIMAT0005929	57085
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ATRAP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1275	rs372458638 chr6:34000019    A/AAAACC rs377188203 chr6:34000023    C/T rs557928121 chr6:34000019    A/T rs758811783 chr6:34000022    G/A rs761034364 chr6:34000017    AGAC/A rs370361021 chr6:34000029    C/A rs370361021 chr6:34000029    C/T rs374728385 chr6:34000032    C/A rs374728385 chr6:34000032    C/G rs747378297 chr6:34000028    C/T rs772691699 chr6:34000033    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AGTRAP	chr1:11803334(+) A-I      intronic chr1:11799353(+) A-I      intronic chr1:11804146(+) A-I      intronic chr1:11804123(+) A-I      intronic chr1:11802727(+) A-I      intronic chr1:11802717(+) A-I      intronic chr1:11804174(+) A-I      intronic chr1:11802692(+) A-I      intronic chr1:11799458(+) A-I      intronic chr1:11799412(+) A-I      intronic chr1:11799398(+) A-I      intronic chr1:11799407(+) A-I      intronic chr1:11799457(+) A-I      intronic chr1:11803421(+) A-I      intronic chr1:11803406(+) A-I      intronic chr1:11803403(+) A-I      intronic chr1:11802705(+) A-I      intronic chr1:11802649(+) A-I      intronic chr1:11804127(+) A-I      intronic chr1:11804221(+) A-I      intronic chr1:11804172(+) A-I      intronic chr1:11799461(+) A-I      intronic chr1:11803809(+) A-I      intronic chr1:11803823(+) A-I      intronic chr1:11799452(+) A-I      intronic chr1:11803723(+) A-I      intronic chr1:11804099(+) A-I      intronic chr1:11804992(+) A-I      intronic chr1:11803875(+) A-I      intronic chr1:11805146(+) A-I      intronic chr1:11805029(+) A-I      intronic chr1:11804211(+) A-I      intronic chr1:11803769(+) A-I      intronic chr1:11804201(+) A-I      intronic chr1:11802753(+) A-I      intronic chr1:11804277(+) A-I      intronic chr1:11804976(+) A-I      intronic chr1:11804182(+) A-I      intronic chr1:11803806(+) A-I      intronic chr1:11804132(+) A-I      intronic chr1:11804273(+) A-I      intronic chr1:11805121(+) A-I      intronic chr1:11804257(+) A-I      intronic chr1:11803724(+) A-I      intronic chr1:11802735(+) A-I      intronic chr1:11804238(+) A-I      intronic chr1:11805061(+) A-I      intronic chr1:11803884(+) A-I      intronic chr1:11802688(+) A-I      intronic chr1:11802797(+) A-I      intronic chr1:11802771(+) A-I      intronic chr1:11804061(+) A-I      intronic chr1:11802614(+) A-I      intronic chr1:11803383(+) A-I      intronic chr1:11803885(+) A-I      intronic chr1:11803803(+) A-I      intronic chr1:11802849(+) A-I      intronic chr1:11802754(+) A-I      intronic chr1:11802700(+) A-I      intronic chr1:11802638(+) A-I      intronic chr1:11803483(+) A-I      intronic chr1:11804147(+) A-I      intronic chr1:11802687(+) A-I      intronic chr1:11799379(+) A-I      intronic chr1:11802877(+) A-I      intronic chr1:11803420(+) A-I      intronic chr1:11804247(+) A-I      intronic chr1:11804173(+) A-I      intronic chr1:11804235(+) A-I      intronic chr1:11803765(+) A-I      intronic chr1:11804938(+) A-I      intronic chr1:11804251(+) A-I      intronic chr1:11799501(+) A-I      intronic chr1:11804252(+) A-I      intronic chr1:11804108(+) A-I      intronic chr1:11810410(+) A-I      3'UTR chr1:11803677(+) A-I      intronic chr1:11802793(+) A-I      intronic chr1:11799487(+) A-I      intronic chr1:11804168(+) A-I      intronic chr1:11804151(+) A-I      intronic chr1:11804171(+) A-I      intronic chr1:11803897(+) A-I      intronic chr1:11804078(+) A-I      intronic chr1:11804077(+) A-I      intronic chr1:11804185(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	AGTRAP	chr1:11810410(+) A-I exon 3'UTR    19478186 chr1:11799507(+) T-C intron -    22484847 chr1:11802688(+) A-G intron -    22484847 chr1:11803483(+) A-G intron -    22484847 chr1:11803765(+) A-G intron -    22484847 chr1:11803803(+) A-G intron -    22484847 chr1:11804061(+) A-G intron -    22484847 chr1:11804077(+) A-G intron -    22484847 chr1:11804078(+) A-G intron -    22484847 chr1:11804147(+) A-G intron -    22484847 chr1:11804151(+) A-G intron -    22484847 chr1:11804168(+) A-G intron -    22484847 chr1:11804251(+) A-G intron -    22484847 chr1:11804252(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AGTRAP	chr1:11796284-11796285(+) m6A CDS//exon       24981863 chr1:11810154-11810155(+) m6A 3'UTR//CDS//exon       - chr1:11810337-11810338(+) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22575960//22608085 chr1:11810377-11810378(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22575960//22608085 chr1:11810434-11810435(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22575960//22608085 chr1:11810486-11810487(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22575960 chr1:11814552-11814553(+) m6A exon       25456834 chr1:11814557-11814558(+) m6A exon       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1275	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     - Mitochondrion HeLa cells     27396686 Mitochondrion HeLa cells     27563705 Mitochondrion Cell line (HeLa)     21695135 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus HeLa cells     23940654
	AGTRAP	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1275	Gemcitabine 60750 Drug interaction    RC00007825 Vincristine 5978 Drug interaction    RC00007823 Eloxatine 5310940 Drug interaction    RC00007826 Paclitaxel 36314 Drug interaction    RC00007824 5-Fluorouracil 3385 Drug interaction    RC00007822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821 Marine fungal metabolite 1386A - Drug interaction    RC00007827

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1275	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1275
Interactor2: AGTRAP

Evidence Support:

Weak-Evidence	Small RNA sequencing
Prediction-Evidence	miRNet
Support Database	ViRBase

References:

PMID	33045840	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	PBMC cells	Interactor2 expression	Upregulation
Description	FIG. 2.(A) Downregulated miRNAs with their predicted upregulated gene targets.