Detail Information

Basic Information:


  VIRBase ID:  

HHID00096468

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:           PHLDA3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1275 PHLDA3
miRBase
Accession/Entrez ID		 MIMAT0005929 23612
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - TIH1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1275
rs372458638 chr6:34000019    A/AAAACC
rs377188203 chr6:34000023    C/T
rs557928121 chr6:34000019    A/T
rs758811783 chr6:34000022    G/A
rs761034364 chr6:34000017    AGAC/A
rs370361021 chr6:34000029    C/A
rs370361021 chr6:34000029    C/T
rs374728385 chr6:34000032    C/A
rs374728385 chr6:34000032    C/G
rs747378297 chr6:34000028    C/T
rs772691699 chr6:34000033    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PHLDA3
chr1:201435758(-) A-I      intronic
chr1:201435752(-) A-I      intronic
chr1:201435852(-) A-I      intronic
chr1:201435696(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PHLDA3
chr1:201436349(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PHLDA3
chr1:201433868-201433869(-) m6A 3'UTR       24981863
chr1:201433888-201433889(-) m6A 3'UTR       24981863
chr1:201433915-201433916(-) m6A 3'UTR       24981863//22608085
chr1:201433925-201433926(-) m6A 3'UTR       24981863//22608085
chr1:201433951-201433952(-) m6A 3'UTR       24981863//22608085
chr1:201434203-201434204(-) m6A 3'UTR       24209618//24981863
chr1:201434789-201434790(-) m6A 3'UTR       24284625//25456834//24981863
chr1:201434865-201434866(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr1:201435018-201435019(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27371828//27773536//22575960//22608085
chr1:201435126-201435127(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27371828//27773536//22575960//22608085
chr1:201435135-201435136(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27371828//27773536//22575960//22608085
chr1:201435515-201435516(-) m6A exon//intron       24284625
chr1:201436628-201436629(-) m6A exon//intron       24209618
chr1:201437529-201437530(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773536
chr1:201437544-201437545(-) m6A CDS//exon       24284625//24981863//26404942//27773536
chr1:201437550-201437551(-) m6A CDS//exon       24284625//24981863//26404942//27773536
chr1:201437577-201437578(-) m6A CDS//exon       24284625//24981863//26404942//27773536
chr1:201437594-201437595(-) m6A CDS//exon       24284625//24981863//26404942//27773536
chr1:201437927-201437928(-) m6A 5'UTR       24284625//24209618//27371828//27773536//22575960
chr1:201438259-201438260(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr1:201438301-201438302(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1275
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion HeLa cells     27396686
Mitochondrion HeLa cells     27563705
Mitochondrion Cell line (HeLa)     21695135
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus HeLa cells     23940654
PHLDA3
Exosome Blood     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1275
Gemcitabine 60750 Drug interaction    RC00007825
Vincristine 5978 Drug interaction    RC00007823
Eloxatine 5310940 Drug interaction    RC00007826
Paclitaxel 36314 Drug interaction    RC00007824
5-Fluorouracil 3385 Drug interaction    RC00007822
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821
Marine fungal metabolite 1386A - Drug interaction    RC00007827
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1275
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1275
Interactor2: PHLDA3

Evidence Support:


Weak-Evidence Small RNA sequencing
Prediction-Evidence miRNet
Support Database ViRBase

References:


PMID 33045840 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line PBMC cells Interactor2 expression Upregulation
Description FIG. 2.(A) Downregulated miRNAs with their predicted upregulated gene targets.

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