Basic Information:

  VIRBase ID:  

HHID00096432

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-424-3p:  MIMAT0004749          PTGR2:  NM_001371330     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-424-3p	PTGR2
miRBase Accession/Entrez ID	MIMAT0004749	145482
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HEL-S-298//PGR2//ZADH1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-424-3p	rs1240344565 chrX:134546644    A/G rs1245299737 chrX:134546652    G/A rs1245299737 chrX:134546652    G/C rs1292655901 chrX:134546653    C/A rs1476106578 chrX:134546647    G/A rs745987032 chrX:134546654    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PTGR2	chr14:74333737(+) A-I      intronic chr14:74344969(+) A-I      intronic chr14:74329528(+) A-I      intronic chr14:74344968(+) A-I      intronic chr14:74344950(+) A-I      intronic chr14:74344971(+) A-I      intronic chr14:74322203(+) A-I      intronic chr14:74344978(+) A-I      intronic chr14:74344651(+) A-I      intronic chr14:74344977(+) A-I      intronic chr14:74344973(+) A-I      intronic chr14:74351809(+) A-I      3'UTR chr14:74344926(+) A-I      intronic chr14:74344925(+) A-I      intronic chr14:74332192(+) A-I      intronic chr14:74351833(+) A-I      3'UTR chr14:74351838(+) A-I      3'UTR chr14:74351797(+) A-I      3'UTR chr14:74351840(+) A-I      3'UTR chr14:74333742(+) A-I      intronic chr14:74344920(+) A-I      intronic chr14:74344919(+) A-I      intronic chr14:74344921(+) A-I      intronic chr14:74333346(+) A-I      intronic chr14:74351807(+) A-I      3'UTR chr14:74333347(+) A-I      intronic chr14:74333348(+) A-I      intronic chr14:74333741(+) A-I      intronic chr14:74323793(+) A-I      intronic chr14:74344759(+) A-I      intronic chr14:74336981(+) A-I      intronic chr14:74322638(+) A-I      intronic chr14:74322423(+) A-I      intronic chr14:74344092(+) A-I      intronic chr14:74344794(+) A-I      intronic chr14:74333616(+) A-I      intronic chr14:74333672(+) A-I      intronic chr14:74333671(+) A-I      intronic chr14:74333681(+) A-I      intronic chr14:74329560(+) A-I      intronic chr14:74341727(+) A-I      intronic chr14:74322411(+) A-I      intronic chr14:74320886(+) A-I      intronic chr14:74336982(+) A-I      intronic chr14:74329620(+) A-I      intronic chr14:74329550(+) A-I      intronic chr14:74344032(+) A-I      intronic chr14:74324246(+) A-I      intronic chr14:74325089(+) A-I      intronic chr14:74324206(+) A-I      intronic chr14:74329552(+) A-I      intronic chr14:74322250(+) A-I      intronic chr14:74322981(+) A-I      intronic chr14:74320044(+) A-I      intronic chr14:74325072(+) A-I      intronic chr14:74324082(+) A-I      intronic chr14:74332779(+) A-I      intronic chr14:74325093(+) A-I      intronic chr14:74325094(+) A-I      intronic chr14:74323755(+) A-I      intronic chr14:74325096(+) A-I      intronic chr14:74325101(+) A-I      intronic chr14:74344704(+) A-I      intronic chr14:74344047(+) A-I      intronic chr14:74341746(+) A-I      intronic chr14:74325105(+) A-I      intronic chr14:74325109(+) A-I      intronic chr14:74332908(+) A-I      intronic chr14:74325125(+) A-I      intronic chr14:74325145(+) A-I      intronic chr14:74325036(+) A-I      intronic chr14:74325095(+) A-I      intronic chr14:74325211(+) A-I      intronic chr14:74344806(+) A-I      intronic chr14:74326656(+) A-I      intronic chr14:74326691(+) A-I      intronic chr14:74319705(+) A-I      intronic chr14:74324214(+) A-I      intronic chr14:74323720(+) A-I      intronic chr14:74323159(+) A-I      intronic chr14:74324571(+) A-I      intronic chr14:74341984(+) A-I      intronic chr14:74332880(+) A-I      intronic chr14:74326793(+) A-I      intronic chr14:74328359(+) A-I      intronic chr14:74327020(+) A-I      intronic chr14:74327049(+) A-I      intronic chr14:74325047(+) A-I      intronic chr14:74327050(+) A-I      intronic chr14:74332822(+) A-I      intronic chr14:74332844(+) A-I      intronic chr14:74332850(+) A-I      intronic chr14:74333542(+) A-I      intronic chr14:74341837(+) A-I      intronic chr14:74329480(+) A-I      intronic chr14:74319553(+) A-I      intronic chr14:74322644(+) A-I      intronic chr14:74344042(+) A-I      intronic chr14:74329485(+) A-I      intronic chr14:74322648(+) A-I      intronic chr14:74333627(+) A-I      intronic chr14:74329490(+) A-I      intronic chr14:74325031(+) A-I      intronic chr14:74324501(+) A-I      intronic chr14:74319776(+) A-I      intronic chr14:74341763(+) A-I      intronic chr14:74329510(+) A-I      intronic chr14:74344597(+) A-I      intronic chr14:74324305(+) A-I      intronic chr14:74321079(+) A-I      intronic chr14:74324574(+) A-I      intronic chr14:74322639(+) A-I      intronic chr14:74329543(+) A-I      intronic chr14:74351988(+) A-I      3'UTR chr14:74351845(+) A-I      3'UTR chr14:74351952(+) A-I      3'UTR chr14:74351746(+) A-I      3'UTR chr14:74351937(+) A-I      3'UTR chr14:74351912(+) A-I      3'UTR chr14:74351822(+) A-I      3'UTR chr14:74351806(+) A-I      3'UTR chr14:74351783(+) A-I      3'UTR chr14:74351871(+) A-I      3'UTR chr14:74351792(+) A-I      3'UTR chr14:74351730(+) A-I      3'UTR chr14:74351729(+) A-I      3'UTR chr14:74344109(+) A-I      intronic chr14:74344242(+) A-I      intronic chr14:74332194(+) A-I      intronic chr14:74322401(+) A-I      intronic chr14:74333630(+) A-I      intronic chr14:74322173(+) A-I      intronic chr14:74333713(+) A-I      intronic chr14:74331857(+) A-I      intronic chr14:74320906(+) A-I      intronic chr14:74345755(+) A-I      intronic chr14:74324140(+) A-I      intronic chr14:74333330(+) A-I      intronic chr14:74344189(+) A-I      intronic chr14:74344048(+) A-I      intronic chr14:74333699(+) A-I      intronic chr14:74344660(+) A-I      intronic chr14:74333537(+) A-I      intronic chr14:74324083(+) A-I      intronic chr14:74326735(+) A-I      intronic chr14:74324138(+) A-I      intronic chr14:74324579(+) A-I      intronic chr14:74325018(+) A-I      intronic chr14:74344107(+) A-I      intronic chr14:74332180(+) A-I      intronic chr14:74324646(+) A-I      intronic chr14:74325201(+) A-I      intronic chr14:74339426(+) A-I      intronic chr14:74321073(+) A-I      intronic chr14:74344659(+) A-I      intronic chr14:74344788(+) A-I      intronic chr14:74323013(+) A-I      intronic chr14:74336180(+) A-I      intronic chr14:74344735(+) A-I      intronic chr14:74344738(+) A-I      intronic chr14:74319554(+) A-I      intronic chr14:74319758(+) A-I      intronic chr14:74344177(+) A-I      intronic chr14:74333698(+) A-I      intronic chr14:74322267(+) A-I      intronic chr14:74320155(+) A-I      intronic chr14:74331829(+) A-I      intronic chr14:74324130(+) A-I      intronic chr14:74323703(+) A-I      intronic chr14:74333485(+) A-I      intronic chr14:74319130(+) A-I      intronic chr14:74329448(+) A-I      intronic chr14:74333736(+) A-I      intronic chr14:74344790(+) A-I      intronic chr14:74344230(+) A-I      intronic chr14:74320130(+) A-I      intronic chr14:74320899(+) A-I      intronic chr14:74332220(+) A-I      intronic chr14:74323697(+) A-I      intronic chr14:74324197(+) A-I      intronic chr14:74325044(+) A-I      intronic chr14:74333689(+) A-I      intronic chr14:74344168(+) A-I      intronic chr14:74323719(+) A-I      intronic chr14:74319724(+) A-I      intronic chr14:74333326(+) A-I      intronic chr14:74344679(+) A-I      intronic chr14:74324603(+) A-I      intronic chr14:74332218(+) A-I      intronic chr14:74330679(+) A-I      intronic chr14:74332362(+) A-I      intronic chr14:74319552(+) A-I      intronic chr14:74344743(+) A-I      intronic chr14:74322969(+) A-I      intronic chr14:74333327(+) A-I      intronic chr14:74328318(+) A-I      intronic chr14:74341975(+) A-I      intronic chr14:74322181(+) A-I      intronic chr14:74332260(+) A-I      intronic chr14:74324557(+) A-I      intronic chr14:74324066(+) A-I      intronic chr14:74330081(+) A-I      intronic chr14:74324091(+) A-I      intronic chr14:74324061(+) A-I      intronic chr14:74322505(+) A-I      intronic chr14:74323760(+) A-I      intronic chr14:74328238(+) A-I      intronic chr14:74322288(+) A-I      intronic chr14:74334004(+) A-I      intronic chr14:74344646(+) A-I      intronic chr14:74333350(+) A-I      intronic chr14:74332259(+) A-I      intronic chr14:74329679(+) A-I      intronic chr14:74319161(+) A-I      intronic chr14:74349726(+) A-I      intronic chr14:74328661(+) A-I      intronic chr14:74329672(+) A-I      intronic chr14:74344097(+) A-I      intronic chr14:74332193(+) A-I      intronic chr14:74333365(+) A-I      intronic chr14:74333631(+) A-I      intronic chr14:74328388(+) A-I      intronic chr14:74329646(+) A-I      intronic chr14:74324115(+) A-I      intronic chr14:74341701(+) A-I      intronic chr14:74322332(+) A-I      intronic chr14:74328324(+) A-I      intronic chr14:74333910(+) A-I      intronic chr14:74333645(+) A-I      intronic chr14:74322236(+) A-I      intronic chr14:74329576(+) A-I      intronic chr14:74333974(+) A-I      intronic chr14:74329594(+) A-I      intronic chr14:74324101(+) A-I      intronic chr14:74331860(+) A-I      intronic chr14:74330398(+) A-I      intronic chr14:74344190(+) A-I      intronic chr14:74323088(+) A-I      intronic chr14:74322338(+) A-I      intronic chr14:74320143(+) A-I      intronic chr14:74351942(+) A-I      3'UTR chr14:74351913(+) A-I      3'UTR chr14:74351817(+) A-I      3'UTR chr14:74351877(+) A-I      3'UTR chr14:74351885(+) A-I      3'UTR chr14:74351881(+) A-I      3'UTR chr14:74351842(+) A-I      3'UTR chr14:74351872(+) A-I      3'UTR chr14:74351863(+) A-I      3'UTR chr14:74351768(+) A-I      3'UTR chr14:74351841(+) A-I      3'UTR chr14:74351904(+) A-I      3'UTR chr14:74351949(+) A-I      3'UTR chr14:74351839(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PTGR2	chr14:74344107(+) A-I intron -    15342557 chr14:74344659(+) A-I intron -    15342557   //22327324 chr14:74344660(+) A-I intron -    15342557 chr14:74344738(+) A-I intron -    15342557 chr14:74344788(+) A-I intron -    15342557 chr14:74344806(+) A-I intron -    15342557 chr14:74345755(+) A-I intron -    15342557 chr14:74332194(+) A-I intron -    22327324 chr14:74351730(+) A-I intron -    21960545 chr14:74332194(+) A-G intron -    22484847 chr14:74332220(+) A-G intron -    22484847 chr14:74344032(+) A-G intron -    22484847 chr14:74344659(+) A-G intron -    22484847 chr14:74351730(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PTGR2	chr14:74318719-74318720(+) m6A 5'UTR//intron       24981863 chr14:74318766-74318767(+) m6A 5'UTR//intron       24981863 chr14:74351370-74351371(+) m6A 3'UTR       24981863//27773535 chr14:74351381-74351382(+) m6A 3'UTR       24981863//27773535 chr14:74351408-74351409(+) m6A 3'UTR       24981863//27773535 chr14:74351463-74351464(+) m6A 3'UTR       24981863//27773535 chr14:74351912-74351913(+) m6A 3'UTR       - chr14:74351997-74351998(+) m6A 3'UTR       27773535//22608085 chr14:74352003-74352004(+) m6A 3'UTR       27773535//22608085 chr14:74352020-74352021(+) m6A 3'UTR       27773535//22608085 chr14:74352041-74352042(+) m6A 3'UTR       27773535//22608085 chr14:74352068-74352069(+) m6A 3'UTR       27773535//22608085 chr14:74352084-74352085(+) m6A 3'UTR       27773535//22608085 chr14:74352138-74352139(+) m6A 3'UTR       27773535//22608085 chr14:74352146-74352147(+) m6A 3'UTR       27773535//22608085 chr14:74352240-74352241(+) m6A 3'UTR       27773535 chr14:74352832-74352833(+) m6A 3'UTR       24209618//27773535//22608085 chr14:74352882-74352883(+) m6A 3'UTR       24209618//27773535//22608085 chr14:74352964-74352965(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr14:74353028-74353029(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr14:74353066-74353067(+) m6A 3'UTR       24284625//24209618//22608085 chr14:74353072-74353073(+) m6A 3'UTR       24284625//24209618//22608085 chr14:74353107-74353108(+) m6A 3'UTR       24284625//24209618//22608085 chr14:74353142-74353143(+) m6A 3'UTR       24209618//22608085 chr14:74353166-74353167(+) m6A 3'UTR       24209618//22608085 chr14:74353242-74353243(+) m6A 3'UTR       - chr14:74353315-74353316(+) m6A 3'UTR       27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-424-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Endothelial cells     - Microvesicle Follicular fluid     23666971 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	PTGR2	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-424-3p	Paclitaxel 36314       27500472 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-424-3p
Interactor2: PTGR2

Evidence Support:

Weak-Evidence	Small RNA sequencing
Prediction-Evidence	miRNet
Support Database	ViRBase

References:

PMID	33045840	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	PBMC cells	Interactor2 expression	Upregulation
Description	FIG. 2.(A) Downregulated miRNAs with their predicted upregulated gene targets.