Detail Information

Basic Information:


  VIRBase ID:  

HHID00096426

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-151a-5p:           DYRK1B:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-151a-5p DYRK1B
miRBase
Accession/Entrez ID		 MIMAT0004697 9149
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AOMS3//MIRK

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-151a-5p
rs1392356121 chr8:140732631    GT/G
rs1399035760 chr8:140732629    C/A
rs1399035760 chr8:140732629    C/T
rs550625412 chr8:140732626    A/G
rs768604798 chr8:140732630    T/A
rs768604798 chr8:140732630    T/G
rs769855308 chr8:140732627    G/A
rs779702312 chr8:140732633    G/A
rs781156276 chr8:140732623    A/T
rs1351879603 chr8:140732642    G/A
rs748804689 chr8:140732641    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DYRK1B
chr19:40320047(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DYRK1B
chr19:40316069-40316070(-) m6A 3'UTR       24981863//27773535//22608085
chr19:40316087-40316088(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr19:40316112-40316113(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr19:40316158-40316159(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr19:40316163-40316164(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr19:40316464-40316465(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536
chr19:40316632-40316633(-) m6A CDS       24284625//24981863
chr19:40316671-40316672(-) m6A CDS       -
chr19:40316893-40316894(-) m6A CDS       -
chr19:40317608-40317609(-) m6A CDS//intron       -
chr19:40317933-40317934(-) m6A CDS       -
chr19:40317953-40317954(-) m6A CDS       -
chr19:40318006-40318007(-) m6A CDS       -
chr19:40318051-40318052(-) m6A CDS       -
chr19:40321120-40321121(-) m6A CDS       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-151a-5p
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Blood|Breast milk|Mast cells|Seminal fluid     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
Mitochondrion Myotube     27396686
Mitochondrion Skeletal muscle cells     27563705
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
DYRK1B
Exosome Blood     -
Nucleolus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-151a-5p
Oxaliplatine 6857599 Drug interaction    RC00007101
Eloxatine 5310940 Drug interaction    RC00007100
Cholecalciferol 5280795 Drug interaction    RC00007099
5-Fluorouracil 3385 Drug interaction    RC00007098
Leucovorin 135403648 Drug interaction    RC00007102
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-151a-5p
Imatinib 5291       25349971

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-151a-5p
Interactor2: DYRK1B

Evidence Support:


Weak-Evidence Small RNA sequencing
Prediction-Evidence miRNet
Support Database ViRBase

References:


PMID 33045840 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line PBMC cells Interactor2 expression Downregulation
Description FIG. 2.(B) upregulated miRNAs with their predicted downregulated gene targets.

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