Basic Information:

  VIRBase ID:  

HHID00096423

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-150-3p:  MIMAT0004610          NBPF10:  NM_001039703     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-150-3p	NBPF10
miRBase Accession/Entrez ID	MIMAT0004610	100132406
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AB6//AG1//NBPF9

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-150-3p	rs1222701309 chr19:49500798    T/C rs1268655804 chr19:49500801    C/T rs1479556921 chr19:49500803    C/A rs900688289 chr19:49500802    C/T rs1184577625 chr19:49500811    T/C rs1270941119 chr19:49500816    C/T rs1413039185 chr19:49500817    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NBPF10	chr1:145369685(+) A-I      3'UTR chr1:145369709(+) A-I      3'UTR chr1:145369712(+) A-I      3'UTR chr1:145369695(+) A-I      3'UTR chr1:145369708(+) A-I      3'UTR chr1:145369498(+) A-I      3'UTR chr1:145369690(+) A-I      3'UTR chr1:145369556(+) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NBPF10	chr1:145290907-145290908(+) m6A intron       24981863 chr1:145290946-145290947(+) m6A intron       24981863 chr1:145293451-145293452(+) m6A CDS//intron       - chr1:145293471-145293472(+) m6A CDS//intron       - chr1:145293500-145293501(+) m6A CDS//intron       - chr1:145293514-145293515(+) m6A CDS//intron       - chr1:145322861-145322862(+) m6A CDS//intron       - chr1:145322912-145322913(+) m6A CDS//intron       24981863 chr1:145322941-145322942(+) m6A CDS//intron       24981863 chr1:145323683-145323684(+) m6A CDS//intron       24981863 chr1:145323689-145323690(+) m6A CDS//intron       24981863 chr1:145324394-145324395(+) m6A CDS//intron       24981863 chr1:145366967-145366968(+) m6A CDS//intron       24981863 chr1:145366996-145366997(+) m6A CDS//intron       24981863//27371828//22608085 chr1:145367753-145367754(+) m1A 3'UTR//CDS//intron       26863410 chr1:145367774-145367775(+) m1A CDS//intron       26863410 chr1:145367797-145367798(+) m1A CDS//intron       26863410 chr1:145367806-145367807(+) m6A CDS//intron       24284625//25456834//24981863//27371828//22608085 chr1:145368487-145368488(+) m6A CDS       24284625//25456834//24981863//22608085 chr1:145368530-145368531(+) m6A CDS       24284625//24981863//22608085 chr1:145368581-145368582(+) m6A CDS       24284625//24981863//22608085 chr1:145368610-145368611(+) m6A CDS       24284625//24981863//22608085 chr1:145368726-145368727(+) m6A 3'UTR       24284625//24981863//22608085 chr1:145368780-145368781(+) m6A 3'UTR       24284625//24981863//22575960//22608085 chr1:145368823-145368824(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:145368857-145368858(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:145368864-145368865(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr1:145368926-145368927(+) m6A 3'UTR       24284625//24981863//22608085 chr1:145368940-145368941(+) m6A 3'UTR       24284625//24981863//22608085 chr1:145369368-145369369(+) Y 3'UTR       26075521 chr1:145369753-145369754(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-150-3p	Exosome Saliva     19627513 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	NBPF10	Chromatin K562 cells     - Exosome Blood     - Nucleus Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-150-3p	Ginsenoside Rh2 119307 Drug interaction    RC00006970 Androstanolone 10635 Drug interaction    RC00006969

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-150-3p	Imatinib 5291       25349971

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-150-3p
Interactor2: NBPF10

Evidence Support:

Weak-Evidence	Small RNA sequencing
Prediction-Evidence	miRNet
Support Database	ViRBase

References:

PMID	33045840	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	PBMC cells	Interactor2 expression	Upregulation
Description	FIG. 2.(A) Downregulated miRNAs with their predicted upregulated gene targets.