Basic Information:

  VIRBase ID:  

HHID00096415

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-146a-3p:  MIMAT0004608          IFITM1:  NM_003641     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-146a-3p	IFITM1
miRBase Accession/Entrez ID	MIMAT0004608	8519
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	9-27//CD225//DSPA2a//IFI17//LEU13

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-146a-3p	rs1323710653 chr5:160485408    C/T rs1343966428 chr5:160485421    G/C rs529455292 chr5:160485429    G/T rs772931224 chr5:160485420    A/G rs1173033188 chr5:160485411    CT/C rs1234876154 chr5:160485413    G/GA rs2910164 chr5:160485411    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IFITM1	chr11:315267(+) T-C intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFITM1	chr11:313992-313993(+) m6A 5'UTR//intron       25456834//24981863 chr11:314008-314009(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314036-314037(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314088-314089(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314120-314121(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314134-314135(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314184-314185(+) m6A CDS       24284625//25456834//24981863 chr11:314260-314261(+) m6A CDS       - chr11:314928-314929(+) m6A CDS//exon       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-146a-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	IFITM1	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-146a-3p
Interactor2: IFITM1

Evidence Support:

Strong-Evidence	qRT-PCR//Western blot
Support Database	ViRBase

References:

PMID	29961753	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	MT2 cells	Interactor2 expression	Upregulation
Description	HIV-1 restriction factors, MxB, IFITM1 and Tetherin were significantly upregulated at both mRNA and protein levels at day 4 and day 8 when miR-146a was abrogated.