Basic Information:

  VIRBase ID:  

HHID00096413

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-146a-3p:  MIMAT0004608          MX2:  NM_002463     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-146a-3p	MX2
miRBase Accession/Entrez ID	MIMAT0004608	4600
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MXB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-146a-3p	rs1323710653 chr5:160485408    C/T rs1343966428 chr5:160485421    G/C rs529455292 chr5:160485429    G/T rs772931224 chr5:160485420    A/G rs1173033188 chr5:160485411    CT/C rs1234876154 chr5:160485413    G/GA rs2910164 chr5:160485411    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MX2	chr21:42777078(+) A-I      intronic chr21:42777026(+) A-I      intronic chr21:42763388(+) A-I      intronic chr21:42763435(+) A-I      intronic chr21:42763436(+) A-I      intronic chr21:42764798(+) A-I      intronic chr21:42764822(+) A-I      intronic chr21:42764856(+) A-I      intronic chr21:42764870(+) A-I      intronic chr21:42764886(+) A-I      intronic chr21:42764912(+) A-I      intronic chr21:42764913(+) A-I      intronic chr21:42764918(+) A-I      intronic chr21:42762670(+) A-I      intronic chr21:42765012(+) A-I      intronic chr21:42766621(+) A-I      intronic chr21:42776981(+) A-I      intronic chr21:42763337(+) A-I      intronic chr21:42777011(+) A-I      intronic chr21:42777127(+) A-I      intronic chr21:42763382(+) A-I      intronic chr21:42748437(+) A-I      intronic chr21:42762754(+) A-I      intronic chr21:42762878(+) A-I      intronic chr21:42763449(+) A-I      intronic chr21:42764878(+) A-I      intronic chr21:42763378(+) A-I      intronic chr21:42777020(+) A-I      intronic chr21:42777883(+) A-I      intronic chr21:42761405(+) A-I      intronic chr21:42778158(+) A-I      intronic chr21:42766614(+) A-I      intronic chr21:42777090(+) A-I      intronic chr21:42777169(+) A-I      intronic chr21:42777841(+) A-I      intronic chr21:42778177(+) A-I      intronic chr21:42755128(+) A-I      intronic chr21:42763529(+) A-I      intronic chr21:42776958(+) A-I      intronic chr21:42777996(+) A-I      intronic chr21:42757987(+) A-I      intronic chr21:42762818(+) A-I      intronic chr21:42777812(+) A-I      intronic chr21:42766747(+) A-I      intronic chr21:42777060(+) A-I      intronic chr21:42762786(+) A-I      intronic chr21:42778150(+) A-I      intronic chr21:42762812(+) A-I      intronic chr21:42762769(+) A-I      intronic chr21:42777021(+) A-I      intronic chr21:42763350(+) A-I      intronic chr21:42763439(+) A-I      intronic chr21:42777203(+) A-I      intronic chr21:42761435(+) A-I      intronic chr21:42778149(+) A-I      intronic chr21:42764981(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MX2	chr21:42735274(+) A-G intron -    22484847 chr21:42762812(+) A-G intron -    22484847 chr21:42762818(+) A-G intron -    22484847 chr21:42763444(+) A-G intron -    22484847 chr21:42763449(+) A-G intron -    22484847 chr21:42763489(+) A-G intron -    22484847 chr21:42763492(+) A-G intron -    22484847 chr21:42777020(+) A-G intron -    22484847 chr21:42777059(+) A-G intron -    22484847 chr21:42777169(+) A-G intron -    22484847 chr21:42777170(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MX2	chr21:42738742-42738743(+) m6A exon//intron       - chr21:42738835-42738836(+) m6A exon//intron       - chr21:42738857-42738858(+) m6A exon//intron       - chr21:42738908-42738909(+) m6A exon//intron       - chr21:42738928-42738929(+) m6A exon//intron       - chr21:42738947-42738948(+) m6A exon//intron       - chr21:42738953-42738954(+) m6A exon//intron       - chr21:42738961-42738962(+) m6A exon//intron       - chr21:42738979-42738980(+) m6A exon//intron       - chr21:42742141-42742142(+) m6A 5'UTR//intron       - chr21:42742162-42742163(+) m6A 5'UTR//intron       - chr21:42742228-42742229(+) m6A 5'UTR//intron       - chr21:42742443-42742444(+) m6A 5'UTR//intron       - chr21:42749017-42749018(+) m6A CDS       - chr21:42749038-42749039(+) m6A CDS       - chr21:42749059-42749060(+) m6A CDS       - chr21:42749725-42749726(+) m6A CDS       - chr21:42762564-42762565(+) m6A CDS//exon       - chr21:42762606-42762607(+) m6A CDS//exon       - chr21:42762618-42762619(+) m6A CDS//exon       - chr21:42771144-42771145(+) m6A CDS//exon//intron       27773535 chr21:42771191-42771192(+) m6A CDS//exon//intron       27773535 chr21:42771228-42771229(+) m6A CDS//exon//intron       27773535 chr21:42771292-42771293(+) m6A exon//intron       27773535 chr21:42780064-42780065(+) m6A CDS//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-146a-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	MX2	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-146a-3p
Interactor2: MX2

Evidence Support:

Strong-Evidence	qRT-PCR//Western blot
Support Database	ViRBase

References:

PMID	29961753	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	MT2 cells	Interactor2 expression	Upregulation
Description	HIV-1 restriction factors, MxB, IFITM1 and Tetherin were significantly upregulated at both mRNA and protein levels at day 4 and day 8 when miR-146a was abrogated.