Detail Information

Basic Information:


  VIRBase ID:  

HHID00096411

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-146a-3p:           BST2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-146a-3p BST2
miRBase
Accession/Entrez ID		 MIMAT0004608 684
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CD317//HM1.24//TETHERIN

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-146a-3p
rs1323710653 chr5:160485408    C/T
rs1343966428 chr5:160485421    G/C
rs529455292 chr5:160485429    G/T
rs772931224 chr5:160485420    A/G
rs1173033188 chr5:160485411    CT/C
rs1234876154 chr5:160485413    G/GA
rs2910164 chr5:160485411    C/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BST2
chr19:17512145(-) A-I      intronic
chr19:17512156(-) A-I      intronic
chr19:17510983(-) A-I      intronic
chr19:17512758(-) A-I      intronic
chr19:17512713(-) A-I      intronic
chr19:17512211(-) A-I      intronic
chr19:17512164(-) A-I      intronic
chr19:17512759(-) A-I      intronic
chr19:17510977(-) A-I      intronic
chr19:17512939(-) A-I      intronic
chr19:17512036(-) A-I      intronic
chr19:17510967(-) A-I      intronic
chr19:17510965(-) A-I      intronic
chr19:17510927(-) A-I      intronic
chr19:17509551(-) A-I      intronic
chr19:17509524(-) A-I      intronic
chr19:17509358(-) A-I      intronic
chr19:17507840(-) A-I      intronic
chr19:17507805(-) A-I      intronic
chr19:17507773(-) A-I      intronic
chr19:17507671(-) A-I      intronic
chr19:17507546(-) A-I      intronic
chr19:17504287(-) A-I      intronic
chr19:17504294(-) A-I      intronic
chr19:17507777(-) A-I      intronic
chr19:17512063(-) A-I      intronic
chr19:17507533(-) A-I      intronic
chr19:17507526(-) A-I      intronic
chr19:17507135(-) A-I      intronic
chr19:17506766(-) A-I      intronic
chr19:17506750(-) A-I      intronic
chr19:17506744(-) A-I      intronic
chr19:17506726(-) A-I      intronic
chr19:17506676(-) A-I      intronic
chr19:17506665(-) A-I      intronic
chr19:17506640(-) A-I      intronic
chr19:17506572(-) A-I      intronic
chr19:17506516(-) A-I      intronic
chr19:17506407(-) A-I      intronic
chr19:17505720(-) A-I      intronic
chr19:17505576(-) A-I      intronic
chr19:17505458(-) A-I      intronic
chr19:17505426(-) A-I      intronic
chr19:17504270(-) A-I      intronic
chr19:17503742(-) A-I      intronic
chr19:17503683(-) A-I      intronic
chr19:17503651(-) A-I      intronic
chr19:17503569(-) A-I      intronic
chr19:17503556(-) A-I      intronic
chr19:17503216(-) A-I      intronic
chr19:17503185(-) A-I      intronic
chr19:17511174(-) A-I      intronic
chr19:17511191(-) A-I      intronic
chr19:17511217(-) A-I      intronic
chr19:17511218(-) A-I      intronic
chr19:17503203(-) A-I      intronic
chr19:17511255(-) A-I      intronic
chr19:17511311(-) A-I      intronic
chr19:17511313(-) A-I      intronic
chr19:17511316(-) A-I      intronic
chr19:17511326(-) A-I      intronic
chr19:17511353(-) A-I      intronic
chr19:17511865(-) A-I      intronic
chr19:17511866(-) A-I      intronic
chr19:17511880(-) A-I      intronic
chr19:17511045(-) A-I      intronic
chr19:17510951(-) A-I      intronic
chr19:17511893(-) A-I      intronic
chr19:17511897(-) A-I      intronic
chr19:17511933(-) A-I      intronic
chr19:17512003(-) A-I      intronic
chr19:17512059(-) A-I      intronic
chr19:17512105(-) A-I      intronic
chr19:17512109(-) A-I      intronic
chr19:17512165(-) A-I      intronic
chr19:17512245(-) A-I      intronic
chr19:17512269(-) A-I      intronic
chr19:17512326(-) A-I      intronic
chr19:17512357(-) A-I      intronic
chr19:17512773(-) A-I      intronic
chr19:17512858(-) A-I      intronic
chr19:17512865(-) A-I      intronic
chr19:17512914(-) A-I      intronic
chr19:17512915(-) A-I      intronic
chr19:17510874(-) A-I      intronic
chr19:17510847(-) A-I      intronic
chr19:17510537(-) A-I      intronic
chr19:17510468(-) A-I      intronic
chr19:17510330(-) A-I      intronic
chr19:17509547(-) A-I      intronic
chr19:17509518(-) A-I      intronic
chr19:17509382(-) A-I      intronic
chr19:17509345(-) A-I      intronic
chr19:17509154(-) A-I      intronic
chr19:17508540(-) A-I      intronic
chr19:17512975(-) A-I      intronic
chr19:17513231(-) A-I      intronic
chr19:17513177(-) A-I      intronic
chr19:17506561(-) A-I      intronic
chr19:17513153(-) A-I      intronic
chr19:17513121(-) A-I      intronic
chr19:17513111(-) A-I      intronic
chr19:17513095(-) A-I      intronic
chr19:17508468(-) A-I      intronic
chr19:17508398(-) A-I      intronic
chr19:17508397(-) A-I      intronic
chr19:17508005(-) A-I      intronic
chr19:17507996(-) A-I      intronic
chr19:17507985(-) A-I      intronic
chr19:17507973(-) A-I      intronic
chr19:17507960(-) A-I      intronic
chr19:17507919(-) A-I      intronic
chr19:17507817(-) A-I      intronic
chr19:17507798(-) A-I      intronic
chr19:17507764(-) A-I      intronic
chr19:17507732(-) A-I      intronic
chr19:17507693(-) A-I      intronic
chr19:17507669(-) A-I      intronic
chr19:17507651(-) A-I      intronic
chr19:17507579(-) A-I      intronic
chr19:17507573(-) A-I      intronic
chr19:17507565(-) A-I      intronic
chr19:17507552(-) A-I      intronic
chr19:17507537(-) A-I      intronic
chr19:17505688(-) A-I      intronic
chr19:17507876(-) A-I      intronic
chr19:17509741(-) A-I      intronic
chr19:17511269(-) A-I      intronic
chr19:17507093(-) A-I      intronic
chr19:17511831(-) A-I      intronic
chr19:17511037(-) A-I      intronic
chr19:17512837(-) A-I      intronic
chr19:17510410(-) A-I      intronic
chr19:17503222(-) A-I      intronic
chr19:17508556(-) A-I      intronic
chr19:17505485(-) A-I      intronic
chr19:17507875(-) A-I      intronic
chr19:17510331(-) A-I      intronic
chr19:17511190(-) A-I      intronic
chr19:17506725(-) A-I      intronic
chr19:17505537(-) A-I      intronic
chr19:17511861(-) A-I      intronic
chr19:17509359(-) A-I      intronic
chr19:17505563(-) A-I      intronic
chr19:17512028(-) A-I      intronic
chr19:17507752(-) A-I      intronic
chr19:17506398(-) A-I      intronic
chr19:17509548(-) A-I      intronic
chr19:17510991(-) A-I      intronic
chr19:17507913(-) A-I      intronic
chr19:17510963(-) A-I      intronic
chr19:17503223(-) A-I      intronic
chr19:17506502(-) A-I      intronic
chr19:17507589(-) A-I      intronic
chr19:17511804(-) A-I      intronic
chr19:17505750(-) A-I      intronic
chr19:17511421(-) A-I      intronic
chr19:17512283(-) A-I      intronic
chr19:17509363(-) A-I      intronic
chr19:17512202(-) A-I      intronic
chr19:17506774(-) A-I      intronic
chr19:17503655(-) A-I      intronic
chr19:17513033(-) A-I      intronic
chr19:17506664(-) A-I      intronic
chr19:17507742(-) A-I      intronic
chr19:17507066(-) A-I      intronic
chr19:17504345(-) A-I      intronic
chr19:17503629(-) A-I      intronic
chr19:17510476(-) A-I      intronic
chr19:17507656(-) A-I      intronic
chr19:17505719(-) A-I      intronic
chr19:17511836(-) A-I      intronic
chr19:17506975(-) A-I      intronic
chr19:17511433(-) A-I      intronic
chr19:17507786(-) A-I      intronic
chr19:17512877(-) A-I      intronic
chr19:17512135(-) A-I      intronic
chr19:17512895(-) A-I      intronic
chr19:17508010(-) A-I      intronic
chr19:17509414(-) A-I      intronic
chr19:17507479(-) A-I      intronic
chr19:17512329(-) A-I      intronic
chr19:17510407(-) A-I      intronic
chr19:17504314(-) A-I      intronic
chr19:17506666(-) A-I      intronic
chr19:17511169(-) A-I      intronic
chr19:17512110(-) A-I      intronic
chr19:17507617(-) A-I      intronic
chr19:17512933(-) A-I      intronic
chr19:17505593(-) A-I      intronic
chr19:17511252(-) A-I      intronic
chr19:17510464(-) A-I      intronic
chr19:17511278(-) A-I      intronic
chr19:17503763(-) A-I      intronic
chr19:17509142(-) A-I      intronic
chr19:17511352(-) A-I      intronic
chr19:17503746(-) A-I      intronic
chr19:17505390(-) A-I      intronic
chr19:17512055(-) A-I      intronic
chr19:17511335(-) A-I      intronic
chr19:17507168(-) A-I      intronic
chr19:17510940(-) A-I      intronic
chr19:17506998(-) A-I      intronic
chr19:17503717(-) A-I      intronic
chr19:17510574(-) A-I      intronic
chr19:17511372(-) A-I      intronic
chr19:17509200(-) A-I      intronic
chr19:17504435(-) A-I      intronic
chr19:17506698(-) A-I      intronic
chr19:17512111(-) A-I      intronic
chr19:17511345(-) A-I      intronic
chr19:17512007(-) A-I      intronic
chr19:17503163(-) A-I      intronic
chr19:17509674(-) A-I      intronic
chr19:17512719(-) A-I      intronic
chr19:17512746(-) A-I      intronic
chr19:17512294(-) A-I      intronic
chr19:17507633(-) A-I      intronic
chr19:17510891(-) A-I      intronic
chr19:17507524(-) A-I      intronic
chr19:17507807(-) A-I      intronic
chr19:17507478(-) A-I      intronic
chr19:17512732(-) A-I      intronic
chr19:17511964(-) A-I      intronic
chr19:17503704(-) A-I      intronic
chr19:17504411(-) A-I      intronic
chr19:17509401(-) A-I      intronic
chr19:17507768(-) A-I      intronic
chr19:17512203(-) A-I      intronic
chr19:17503209(-) A-I      intronic
chr19:17505391(-) A-I      intronic
chr19:17507772(-) A-I      intronic
chr19:17505469(-) A-I      intronic
chr19:17507100(-) A-I      intronic
chr19:17510996(-) A-I      intronic
chr19:17509362(-) A-I      intronic
chr19:17512814(-) A-I      intronic
chr19:17505539(-) A-I      intronic
chr19:17513081(-) A-I      intronic
chr19:17509652(-) A-I      intronic
chr19:17505453(-) A-I      intronic
chr19:17505445(-) A-I      intronic
chr19:17507870(-) A-I      intronic
chr19:17512820(-) A-I      intronic
chr19:17510901(-) A-I      intronic
chr19:17510385(-) A-I      intronic
chr19:17504335(-) A-I      intronic
chr19:17507060(-) A-I      intronic
chr19:17510942(-) A-I      intronic
chr19:17512284(-) A-I      intronic
chr19:17511178(-) A-I      intronic
chr19:17513034(-) A-I      intronic
chr19:17512069(-) A-I      intronic
chr19:17513021(-) A-I      intronic
chr19:17511036(-) A-I      intronic
chr19:17503270(-) A-I      intronic
chr19:17506419(-) A-I      intronic
chr19:17511266(-) A-I      intronic
chr19:17504336(-) A-I      intronic
chr19:17512894(-) A-I      intronic
chr19:17505427(-) A-I      intronic
chr19:17512308(-) A-I      intronic
chr19:17503037(-) A-I      intronic
chr19:17510318(-) A-I      intronic
chr19:17503085(-) A-I      intronic
chr19:17506432(-) A-I      intronic
chr19:17509174(-) A-I      intronic
chr19:17511969(-) A-I      intronic
chr19:17503280(-) A-I      intronic
chr19:17512855(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BST2
chr19:17513914-17513915(-) m6A 3'UTR       22575960
chr19:17513963-17513964(-) m6A 3'UTR       22575960
chr19:17514002-17514003(-) Cm 3'UTR       -
chr19:17514093-17514094(-) m6A 3'UTR//exon       27773536//22575960
chr19:17515269-17515270(-) m6A exon//intron       27371828//22575960
chr19:17515284-17515285(-) m6A exon//intron       27371828//22575960
chr19:17515323-17515324(-) m6A exon//intron       27371828//22575960
chr19:17516403-17516404(-) m6A 5'UTR       24284625//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-146a-3p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -
BST2
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-146a-3p
Interactor2: BST2

Evidence Support:


Strong-Evidence qRT-PCR//Western blot
Support Database ViRBase

References:


PMID 29961753 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line MT2 cells Interactor2 expression Upregulation
Description HIV-1 restriction factors, MxB, IFITM1 and Tetherin were significantly upregulated at both mRNA and protein levels at day 4 and day 8 when miR-146a was abrogated.

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