Basic Information:

  VIRBase ID:  

HHID00096401

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-2-3p:  MIMAT0004518          TSLP:  NM_138551     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-2-3p	TSLP
miRBase Accession/Entrez ID	MIMAT0004518	85480
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-2-3p	rs1341798864 chr3:160404818    A/C rs373202341 chr3:160404806    C/T rs768780684 chr3:160404809    T/C rs768780684 chr3:160404809    T/G rs746992239 chr3:160404798    C/CA rs775368833 chr3:160404800    A/G rs775368833 chr3:160404800    A/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TSLP	chr5:110411835-110411836(+) m6A 3'UTR       22608085 chr5:110411862-110411863(+) m6A 3'UTR       22608085 chr5:110412072-110412073(+) m6A 3'UTR       24981863//22608085 chr5:110412103-110412104(+) m6A 3'UTR       24981863//22608085 chr5:110412122-110412123(+) m6A 3'UTR       24981863//22608085 chr5:110412137-110412138(+) m6A 3'UTR       24981863//22608085 chr5:110412178-110412179(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-2-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Blood|Chronic lymphocytic leukemia cells|Tongue tissue     - Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	TSLP	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-2-3p
Interactor2: TSLP

Evidence Support:

Weak-Evidence	Small RNA sequencing
Prediction-Evidence	miRNet
Support Database	ViRBase

References:

PMID	33045840	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	PBMC cells	Interactor2 expression	Upregulation
Description	FIG. 2.(A) Downregulated miRNAs with their predicted upregulated gene targets.