Basic Information:

  VIRBase ID:  

HHID00096396

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-2-3p:  MIMAT0004518          GINS1:  NR_134574     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-2-3p	GINS1
miRBase Accession/Entrez ID	MIMAT0004518	9837
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IMD55//PSF1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-2-3p	rs1341798864 chr3:160404818    A/C rs373202341 chr3:160404806    C/T rs768780684 chr3:160404809    T/C rs768780684 chr3:160404809    T/G rs746992239 chr3:160404798    C/CA rs775368833 chr3:160404800    A/G rs775368833 chr3:160404800    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GINS1	chr20:25391799(+) A-I      ncRNA chr20:25391764(+) A-I      ncRNA chr20:25393719(+) A-I      intronic chr20:25428607(+) A-I      3'UTR chr20:25400379(+) A-I      Syn:Gln->Gln chr20:25391692(+) A-I      intronic chr20:25391337(+) A-I      intronic chr20:25403096(+) A-I      intronic chr20:25416218(+) A-I      intronic chr20:25416216(+) A-I      intronic chr20:25391298(+) A-I      intronic chr20:25391301(+) A-I      intronic chr20:25392470(+) A-I      intronic chr20:25403075(+) A-I      intronic chr20:25403009(+) A-I      intronic chr20:25401439(+) A-I      intronic chr20:25400967(+) A-I      intronic chr20:25393817(+) A-I      intronic chr20:25393757(+) A-I      intronic chr20:25416048(+) A-I      intronic chr20:25392206(+) A-I      intronic chr20:25414813(+) A-I      intronic chr20:25414742(+) A-I      intronic chr20:25408752(+) A-I      intronic chr20:25408008(+) A-I      intronic chr20:25407999(+) A-I      intronic chr20:25407959(+) A-I      intronic chr20:25407824(+) A-I      intronic chr20:25421209(+) A-I      intronic chr20:25420917(+) A-I      intronic chr20:25416518(+) A-I      intronic chr20:25407395(+) A-I      intronic chr20:25416346(+) A-I      intronic chr20:25416229(+) A-I      intronic chr20:25407383(+) A-I      intronic chr20:25407024(+) A-I      intronic chr20:25406998(+) A-I      intronic chr20:25406944(+) A-I      intronic chr20:25404511(+) A-I      intronic chr20:25404510(+) A-I      intronic chr20:25404432(+) A-I      intronic chr20:25404379(+) A-I      intronic chr20:25416223(+) A-I      intronic chr20:25404319(+) A-I      intronic chr20:25393071(+) A-I      intronic chr20:25393070(+) A-I      intronic chr20:25392651(+) A-I      intronic chr20:25392638(+) A-I      intronic chr20:25392539(+) A-I      intronic chr20:25391790(+) A-I      ncRNA chr20:25400403(+) A-I      Syn:Gln->Gln chr20:25427719(+) A-I      3'UTR chr20:25427762(+) A-I      3'UTR chr20:25427841(+) A-I      3'UTR chr20:25427842(+) A-I      3'UTR chr20:25427859(+) A-I      3'UTR chr20:25428749(+) A-I      3'UTR chr20:25400398(+) A-I      NonSyn:Lys->Glu chr20:25391874(+) A-I      ncRNA chr20:25396163(+) A-I      intronic chr20:25406971(+) A-I      intronic chr20:25396128(+) A-I      intronic chr20:25420445(+) A-I      intronic chr20:25391632(+) A-I      intronic chr20:25402948(+) A-I      intronic chr20:25392623(+) A-I      intronic chr20:25420510(+) A-I      intronic chr20:25391732(+) A-I      intronic chr20:25400909(+) A-I      intronic chr20:25418499(+) A-I      intronic chr20:25390926(+) A-I      intronic chr20:25390866(+) A-I      intronic chr20:25391263(+) A-I      intronic chr20:25419322(+) A-I      intronic chr20:25403024(+) A-I      intronic chr20:25403085(+) A-I      intronic chr20:25391633(+) A-I      intronic chr20:25416064(+) A-I      intronic chr20:25390862(+) A-I      intronic chr20:25420420(+) A-I      intronic chr20:25416283(+) A-I      intronic chr20:25416851(+) A-I      intronic chr20:25390927(+) A-I      intronic chr20:25428656(+) A-I      3'UTR chr20:25428624(+) A-I      3'UTR chr20:25428349(+) A-I      3'UTR chr20:25427776(+) A-I      3'UTR chr20:25428750(+) A-I      3'UTR chr20:25427897(+) A-I      3'UTR chr20:25426881(+) A-I      3'UTR chr20:25428606(+) A-I      3'UTR chr20:25428547(+) A-I      3'UTR chr20:25428712(+) A-I      3'UTR chr20:25428512(+) A-I      3'UTR chr20:25426909(+) A-I      3'UTR chr20:25428646(+) A-I      3'UTR chr20:25428727(+) A-I      3'UTR chr20:25427934(+) A-I      3'UTR chr20:25427946(+) A-I      3'UTR chr20:25428308(+) A-I      3'UTR chr20:25428384(+) A-I      3'UTR chr20:25428503(+) A-I      3'UTR chr20:25428294(+) A-I      3'UTR chr20:25428751(+) A-I      3'UTR chr20:25428320(+) A-I      3'UTR chr20:25427755(+) A-I      3'UTR chr20:25427793(+) A-I      3'UTR chr20:25426947(+) A-I      3'UTR chr20:25427898(+) A-I      3'UTR chr20:25428601(+) A-I      3'UTR chr20:25428610(+) A-I      3'UTR chr20:25427695(+) A-I      3'UTR chr20:25428708(+) A-I      3'UTR chr20:25428638(+) A-I      3'UTR chr20:25428663(+) A-I      3'UTR chr20:25428620(+) A-I      3'UTR chr20:25428566(+) A-I      3'UTR chr20:25426906(+) A-I      3'UTR chr20:25427885(+) A-I      3'UTR chr20:25426933(+) A-I      3'UTR chr20:25428695(+) A-I      3'UTR chr20:25426940(+) A-I      3'UTR chr20:25428534(+) A-I      3'UTR chr20:25428544(+) A-I      3'UTR chr20:25393914(+) A-I      intronic chr20:25403853(+) A-I      intronic chr20:25392477(+) A-I      intronic chr20:25393919(+) A-I      intronic chr20:25393894(+) A-I      intronic chr20:25400953(+) A-I      intronic chr20:25392432(+) A-I      intronic chr20:25391694(+) A-I      intronic chr20:25390758(+) A-I      intronic chr20:25407023(+) A-I      intronic chr20:25390823(+) A-I      intronic chr20:25403159(+) A-I      intronic chr20:25404524(+) A-I      intronic chr20:25400935(+) A-I      intronic chr20:25390723(+) A-I      intronic chr20:25391315(+) A-I      intronic chr20:25419310(+) A-I      intronic chr20:25414775(+) A-I      intronic chr20:25420776(+) A-I      intronic chr20:25419252(+) A-I      intronic chr20:25393805(+) A-I      intronic chr20:25418676(+) A-I      intronic chr20:25401255(+) A-I      intronic chr20:25400950(+) A-I      intronic chr20:25393859(+) A-I      intronic chr20:25392215(+) A-I      intronic chr20:25391324(+) A-I      intronic chr20:25404324(+) A-I      intronic chr20:25408073(+) A-I      intronic chr20:25415216(+) A-I      intronic chr20:25391279(+) A-I      intronic chr20:25391327(+) A-I      intronic chr20:25415161(+) A-I      intronic chr20:25391302(+) A-I      intronic chr20:25407070(+) A-I      intronic chr20:25416273(+) A-I      intronic chr20:25391255(+) A-I      intronic chr20:25392414(+) A-I      intronic chr20:25414799(+) A-I      intronic chr20:25418500(+) A-I      intronic chr20:25390945(+) A-I      intronic chr20:25393946(+) A-I      intronic chr20:25416141(+) A-I      intronic chr20:25392420(+) A-I      intronic chr20:25415208(+) A-I      intronic chr20:25419351(+) A-I      intronic chr20:25393786(+) A-I      intronic chr20:25404512(+) A-I      intronic chr20:25416574(+) A-I      intronic chr20:25401240(+) A-I      intronic chr20:25416321(+) A-I      intronic chr20:25403171(+) A-I      intronic chr20:25401338(+) A-I      intronic chr20:25393861(+) A-I      intronic chr20:25403147(+) A-I      intronic chr20:25421353(+) A-I      intronic chr20:25393752(+) A-I      intronic chr20:25390856(+) A-I      intronic chr20:25401269(+) A-I      intronic chr20:25391688(+) A-I      intronic chr20:25415335(+) A-I      intronic chr20:25391857(+) A-I      ncRNA chr20:25391780(+) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GINS1	chr20:25391790(+) A-I intron -    15258596 chr20:25391804(+) A-I intron -    15258596   //22327324 chr20:25391874(+) A-I intron -    15258596 chr20:25427755(+) A-I exon 3'UTR    15258596 chr20:25427756(+) A-I exon 3'UTR    15258596 chr20:25427805(+) A-I exon 3'UTR    15258596 chr20:25427815(+) A-I exon 3'UTR    15258596 chr20:25428294(+) A-I exon 3'UTR    15258596   //21960545 chr20:25428587(+) A-I exon 3'UTR    15258596   //22327324 chr20:25428588(+) A-I exon 3'UTR    15258596   //22327324 chr20:25428646(+) A-I exon 3'UTR    15258596   //22327324 chr20:25428669(+) A-I exon 3'UTR    15258596 chr20:25428695(+) A-I exon 3'UTR    15258596 chr20:25426905(+) A-I intron -    22327324 chr20:25428308(+) A-I intron -    22327324 chr20:25428503(+) A-I intron -    22327324 chr20:25428511(+) A-I intron -    22327324 chr20:25428547(+) A-I intron -    22327324 chr20:25428624(+) A-I intron -    22327324 chr20:25428750(+) A-I intron -    22327324 chr20:25428294(+) A-G intron -    21725310   //22484847 chr20:25428587(+) A-G intron -    21725310   //22484847 chr20:25390823(+) A-G intron -    22484847 chr20:25390856(+) A-G intron -    22484847 chr20:25390862(+) A-G intron -    22484847 chr20:25390866(+) A-G intron -    22484847 chr20:25391633(+) A-G intron -    22484847 chr20:25391790(+) A-G intron -    22484847 chr20:25391804(+) A-G intron -    22484847 chr20:25391857(+) A-G intron -    22484847 chr20:25393859(+) A-G intron -    22484847 chr20:25393861(+) A-G intron -    22484847 chr20:25393894(+) A-G intron -    22484847 chr20:25393919(+) A-G intron -    22484847 chr20:25400909(+) A-G intron -    22484847 chr20:25400935(+) A-G intron -    22484847 chr20:25401269(+) A-G intron -    22484847 chr20:25401360(+) A-G intron -    22484847 chr20:25403967(+) C-T intron -    22484847 chr20:25416851(+) A-G intron -    22484847 chr20:25421353(+) A-G intron -    22484847 chr20:25426871(+) A-G intron -    22484847 chr20:25426881(+) A-G intron -    22484847 chr20:25426905(+) A-G intron -    22484847 chr20:25426940(+) A-G intron -    22484847 chr20:25427756(+) A-G intron -    22484847 chr20:25427776(+) A-G intron -    22484847 chr20:25427805(+) A-G intron -    22484847 chr20:25427815(+) A-G intron -    22484847 chr20:25428308(+) A-G intron -    22484847 chr20:25428320(+) A-G intron -    22484847 chr20:25428348(+) A-G intron -    22484847 chr20:25428384(+) A-G intron -    22484847 chr20:25428511(+) A-G intron -    22484847 chr20:25428512(+) A-G intron -    22484847 chr20:25428547(+) A-G intron -    22484847 chr20:25428588(+) A-G intron -    22484847 chr20:25428590(+) A-G intron -    22484847 chr20:25428601(+) A-G intron -    22484847 chr20:25428606(+) A-G intron -    22484847 chr20:25428620(+) A-G intron -    22484847 chr20:25428624(+) A-G intron -    22484847 chr20:25428646(+) A-G intron -    22484847 chr20:25428669(+) A-G intron -    22484847 chr20:25428722(+) A-G intron -    22484847 chr20:25428724(+) A-G intron -    22484847 chr20:25428750(+) A-G intron -    22484847 chr20:25391627(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GINS1	chr20:25388479-25388480(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr20:25405938-25405939(+) m6A CDS       24981863 chr20:25422353-25422354(+) m6A CDS       24981863 chr20:25426596-25426597(+) m6A CDS//exon       24981863//26404942 chr20:25426667-25426668(+) m6A 3'UTR//exon       24284625//24981863//26404942 chr20:25426731-25426732(+) m6A 3'UTR//intron       24209618//24981863 chr20:25426791-25426792(+) m6A 3'UTR//intron       24209618//24981863 chr20:25427284-25427285(+) m6A 3'UTR//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-2-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Blood|Chronic lymphocytic leukemia cells|Tongue tissue     - Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	GINS1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-2-3p
Interactor2: GINS1

Evidence Support:

Weak-Evidence	Small RNA sequencing
Prediction-Evidence	miRNet
Support Database	ViRBase

References:

PMID	33045840	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	PBMC cells	Interactor2 expression	Upregulation
Description	FIG. 2.(A) Downregulated miRNAs with their predicted upregulated gene targets.