Basic Information:

  VIRBase ID:  

HHID00096394

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-2-3p:  MIMAT0004518          CHI3L2:  NM_001025197     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-2-3p	CHI3L2
miRBase Accession/Entrez ID	MIMAT0004518	1117
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CHIL2//YKL-39//YKL39

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-2-3p	rs1341798864 chr3:160404818    A/C rs373202341 chr3:160404806    C/T rs768780684 chr3:160404809    T/C rs768780684 chr3:160404809    T/G rs746992239 chr3:160404798    C/CA rs775368833 chr3:160404800    A/G rs775368833 chr3:160404800    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CHI3L2	chr1:111769688(+) A-I      intronic chr1:111769896(+) A-I      intronic chr1:111769900(+) A-I      intronic chr1:111769861(+) A-I      intronic chr1:111767350(+) A-I      intronic chr1:111767326(+) A-I      intronic chr1:111769689(+) A-I      intronic chr1:111767393(+) A-I      intronic chr1:111767484(+) A-I      intronic chr1:111773048(+) A-I      intronic chr1:111767264(+) A-I      intronic chr1:111769840(+) A-I      intronic chr1:111769892(+) A-I      intronic chr1:111767265(+) A-I      intronic chr1:111769742(+) A-I      intronic chr1:111769852(+) A-I      intronic chr1:111769738(+) A-I      intronic chr1:111767493(+) A-I      intronic chr1:111769682(+) A-I      intronic chr1:111767472(+) A-I      intronic chr1:111769680(+) A-I      intronic chr1:111769944(+) A-I      intronic chr1:111767420(+) A-I      intronic chr1:111767216(+) A-I      intronic chr1:111769871(+) A-I      intronic chr1:111769762(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CHI3L2	chr1:111743491-111743492(+) m6A 5'UTR       - chr1:111743498-111743499(+) m6A 5'UTR       - chr1:111743518-111743519(+) m6A 5'UTR       - chr1:111743534-111743535(+) m6A 5'UTR       - chr1:111743622-111743623(+) m6A 5'UTR       - chr1:111743653-111743654(+) m6A 5'UTR       - chr1:111743662-111743663(+) m6A 5'UTR       - chr1:111743689-111743690(+) m6A 5'UTR       - chr1:111743740-111743741(+) m6A 5'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-2-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Blood|Chronic lymphocytic leukemia cells|Tongue tissue     - Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	CHI3L2	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-2-3p
Interactor2: CHI3L2

Evidence Support:

Weak-Evidence	Small RNA sequencing
Prediction-Evidence	miRNet
Support Database	ViRBase

References:

PMID	33045840	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	PBMC cells	Interactor2 expression	Upregulation
Description	FIG. 2.(A) Downregulated miRNAs with their predicted upregulated gene targets.