Basic Information:

  VIRBase ID:  

HHID00096393

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-2-3p:  MIMAT0004518          CD9:  NM_001330312     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-2-3p	CD9
miRBase Accession/Entrez ID	MIMAT0004518	928
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BTCC-1//DRAP-27//MIC3//MRP-1//TSPAN-29//TSPAN29

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-2-3p	rs1341798864 chr3:160404818    A/C rs373202341 chr3:160404806    C/T rs768780684 chr3:160404809    T/C rs768780684 chr3:160404809    T/G rs746992239 chr3:160404798    C/CA rs775368833 chr3:160404800    A/G rs775368833 chr3:160404800    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CD9	chr12:6323698(+) A-I      intronic chr12:6323717(+) A-I      intronic chr12:6323712(+) A-I      intronic chr12:6323695(+) A-I      intronic chr12:6317135(+) A-I      intronic chr12:6316258(+) A-I      intronic chr12:6310950(+) A-I      intronic chr12:6311187(+) A-I      intronic chr12:6337720(+) A-I      intronic chr12:6337607(+) A-I      intronic chr12:6337597(+) A-I      intronic chr12:6337595(+) A-I      intronic chr12:6336482(+) A-I      intronic chr12:6327266(+) A-I      intronic chr12:6327195(+) A-I      intronic chr12:6317992(+) A-I      intronic chr12:6317990(+) A-I      intronic chr12:6346533(+) A-I      intronic chr12:6346528(+) A-I      intronic chr12:6317982(+) A-I      intronic chr12:6317973(+) A-I      intronic chr12:6317964(+) A-I      intronic chr12:6317939(+) A-I      intronic chr12:6317214(+) A-I      intronic chr12:6317212(+) A-I      intronic chr12:6317204(+) A-I      intronic chr12:6337727(+) A-I      intronic chr12:6317171(+) A-I      intronic chr12:6337725(+) A-I      intronic chr12:6317162(+) A-I      intronic chr12:6336389(+) A-I      intronic chr12:6317243(+) A-I      intronic chr12:6315666(+) A-I      intronic chr12:6331050(+) A-I      intronic chr12:6315658(+) A-I      intronic chr12:6317205(+) A-I      intronic chr12:6331086(+) A-I      intronic chr12:6346338(+) A-I      intronic chr12:6346524(+) A-I      intronic chr12:6337489(+) A-I      intronic chr12:6316195(+) A-I      intronic chr12:6346168(+) A-I      intronic chr12:6346525(+) A-I      intronic chr12:6317269(+) A-I      intronic chr12:6318318(+) A-I      intronic chr12:6337443(+) A-I      intronic chr12:6336388(+) A-I      intronic chr12:6331040(+) A-I      intronic chr12:6345670(+) A-I      intronic chr12:6317195(+) A-I      intronic chr12:6346537(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CD9	chr12:6316195(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CD9	chr12:6309201-6309202(+) m6A 5'UTR//exon       25456834//24981863 chr12:6309216-6309217(+) m6A 5'UTR//exon       24284625//25456834//24981863 chr12:6309555-6309556(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr12:6309562-6309563(+) Y 5'UTR//intron       26075521 chr12:6344425-6344426(+) m6A CDS//exon       22575960 chr12:6344445-6344446(+) m6A CDS//exon       22575960 chr12:6344645-6344646(+) m6A CDS//exon       22575960 chr12:6344673-6344674(+) m6A CDS//exon       22575960 chr12:6344678-6344679(+) Y CDS//exon       26075521 chr12:6344687-6344688(+) m6A CDS//exon       22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-2-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Blood|Chronic lymphocytic leukemia cells|Tongue tissue     - Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	CD9	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-2-3p
Interactor2: CD9

Evidence Support:

Weak-Evidence	Small RNA sequencing
Prediction-Evidence	miRNet
Support Database	ViRBase

References:

PMID	33045840	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	PBMC cells	Interactor2 expression	Upregulation
Description	FIG. 2.(A) Downregulated miRNAs with their predicted upregulated gene targets.