Basic Information:

  VIRBase ID:  

HHID00096366

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-497-5p:  MIMAT0002820          DLEU1:  NR_109973     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-497-5p	DLEU1
miRBase Accession/Entrez ID	MIMAT0002820	10301
Organism	Homo sapiens	Homo sapiens
Category	miRNA	lncRNA
Alias	-	BCMS//BCMS1//DLB1//DLEU2//LEU1//LEU2//LINC00021//NCRNA00021//XTP6

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-497-5p	rs1050536403 chr17:7017990    T/G rs1217216293 chr17:7017999    G/A rs1239642436 chr17:7017988    A/G rs1283992109 chr17:7017989    G/A rs1315164260 chr17:7017979    A/G rs753897817 chr17:7017984    CCA/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DLEU1	chr13:50670267(+) A-I      intronic chr13:50674238(+) A-I      intronic chr13:50678118(+) A-I      intronic chr13:50678140(+) A-I      intronic chr13:50678117(+) A-I      intronic chr13:50666580(+) A-I      intronic chr13:50674107(+) A-I      intronic chr13:50666629(+) A-I      intronic chr13:50678143(+) A-I      intronic chr13:50660018(+) A-I      intronic chr13:50666623(+) A-I      intronic chr13:50666622(+) A-I      intronic chr13:50674055(+) A-I      intronic chr13:50666610(+) A-I      intronic chr13:50666740(+) A-I      intronic chr13:50692946(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DLEU1	chr13:50656420-50656421(+) m6A 5'UTR//exon       24284625//24209618//24981863 chr13:50656494-50656495(+) m6A 5'UTR//exon       24284625 chr13:50656549-50656550(+) m6A 5'UTR//exon       24284625 chr13:50656556-50656557(+) m6A 5'UTR//exon       24284625 chr13:50656577-50656578(+) m6A CDS//exon       24284625 chr13:50656607-50656608(+) m6A CDS//exon       24284625 chr13:50656680-50656681(+) m6A CDS//exon       24284625 chr13:50657283-50657284(+) m6A CDS//exon//intron       24284625 chr13:50657326-50657327(+) m6A 3'UTR//exon//intron       24284625 chr13:50678864-50678865(+) m6A 3'UTR//CDS//intron       24981863//22608085 chr13:50678869-50678870(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr13:50678896-50678897(+) m6A 3'UTR//CDS//intron       24284625//22608085 chr13:50678976-50678977(+) m6A 3'UTR//intron       22608085 chr13:50679025-50679026(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr13:50679040-50679041(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr13:50679145-50679146(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr13:50679153-50679154(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr13:50700435-50700436(+) m6A intron       - chr13:50700461-50700462(+) m6A intron       - chr13:50700520-50700521(+) m6A intron       - chr13:50700526-50700527(+) m6A intron       - chr13:50700534-50700535(+) m6A intron       - chr13:50700591-50700592(+) m6A intron       - chr13:50701201-50701202(+) m6A intron       - chr13:50701258-50701259(+) m6A intron       - chr13:50701785-50701786(+) m6A intron       - chr13:50701898-50701899(+) m6A intron       - chr13:50701931-50701932(+) m6A intron       - chr13:50701941-50701942(+) m6A intron       - chr13:50702027-50702028(+) m6A intron       - chr13:50702131-50702132(+) m6A intron       - chr13:50702152-50702153(+) m6A intron       - chr13:50702164-50702165(+) m6A intron       - chr13:50702219-50702220(+) m6A intron       - chr13:50702238-50702239(+) m6A intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-497-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Mast cells     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Hepatoma cells     23771658 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	DLEU1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HCC cell line (HepG2)     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-497-5p	(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant Acridine Yellow G 8672 Drug resistant 1,9-Pyrazoloanthrone 8515 Drug resistant 5-Methyl-1,10-phenanthroline 72791 Drug resistant 2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive Berberine iodide 72350 Drug sensitive Thiocoraline 70698112 Drug resistant 1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant Kikubasaponin 6712587 Drug resistant Ixabepilone 6445540 Drug sensitive 5-Bromo-3-(2-oxo-2-phenylethylidene)-1,3-dihydroindol-2-one 5477132 Drug resistant 21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive 2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive Reumycin 5351216 Drug resistant 1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant 5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive Centaureidin 5315773 Drug sensitive Alvocidib 5287969 Drug resistant Amonafide 50515 Drug resistant Bindschedler's green 458960 Drug sensitive Justicidin B 442882 Drug resistant Massoia lactone 39914 Drug resistant 1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant Stereoisomer of NSC 674066-O 384359 Drug resistant Miltefosine 3599 Drug resistant 2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive 2-(7-Aminotriazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)oxolane-3,4-diol 251928 Drug resistant 9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug resistant Olaparib 23725625 Drug sensitive Spongiaquinone 23424796 Drug sensitive Verrucarin A 9,10-epoxide 181390 Drug resistant Aklavin 149755 Drug resistant Perifosine 148177 Drug resistant Edelfosine 1392 Drug resistant (1R,6R,13S)-16,17-Dimethoxy-6-propan-2-yl-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one 13845974 Drug sensitive Astrazon Orange R 135747272 Drug sensitive 1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive Abiraterone 132971 Drug sensitive Octadecylphosphocholine 125219 Drug resistant 3-(4-(5-Methoxy-1H-benzo[d]imidazol-2-yl)phenyl)-5-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazole 118624714 Drug sensitive Pararosaniline hydrochloride 11292 Drug sensitive 1-Phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole 11162021 Drug resistant Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant 4-methoxy-2,6-bis[hydroxy(methyl)amino]-1,3,5-triazine - Drug resistant arylpurines - Drug resistant methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant tunicamycin - Drug resistant 2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive 3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine-5-carboxamide - Drug sensitive naphtho[1,2-b]quinolizinium, 10,13-dimethyl- chloride - Drug sensitive naphtho[2,1-b]quinolizinium, 7-methyl- chloride - Drug sensitive phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive 2-(4-methylthio-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive peliomycin (usan) - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-497-5p	Bufalin 9547215 Drug interaction    RC00005478 Ethanol 702 Drug interaction    RC00005464 Gemcitabine 60750 Drug interaction    RC00005473 Testosterone 6013 Drug interaction    RC00005470 Vincristine 5978 Drug interaction    RC00005469 Temozolomide 5394 Drug interaction    RC00005468 Eloxatine 5310940 Drug interaction    RC00005477 Diethylstilbestrol 448537 Drug interaction    RC00005476 Paclitaxel 36314 Drug interaction    RC00005472 5-Fluorouracil 3385 Drug interaction    RC00005467 Doxorubicin 31703 Drug interaction    RC00005471 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005466 Verapamil 2520 Drug interaction    RC00005465 Erlotinib 176870 Drug interaction    RC00005475 Gefitinib 123631 Drug interaction    RC00005474 TRAIL therapy - Drug interaction    RC00005481 platinum-based doublet chemotherapy - Drug interaction    RC00005479 Rituximab - Drug interaction    RC00005480

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	DLEU1	6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide       9956222 Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride       9938202 1,2-Ethanediamine, N-(1,8-dimethylimidazo(1,2-a)quinoxalin-4-yl)-, monohydrochloride       9926054 Tivozanib       9911830 Zibotentan       9910224 Piperidine, 2-methyl-6-undecyl-       99090 5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786 PI-103       9884685 Osi-930       9868037 2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine       9858940 N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528 8-Hydroxy-7-(6-sulfo-naphthalen-2-ylazo)-quinoline-5-sulfonic acid       92577 Trimelamol       92368 N-Acetylsulfanilyl chloride       8481 Phenformin       8249 N-(3-Methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine       704473 (S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide       6918848 Panobinostat       6918837 Belinostat       6918638 Daporinad       6914657 N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide       6852167 AICA ribonucleotide       65110 Tanespimycin       6505803 Ispinesib mesylate       6450816 Axitinib       6450551 Nilotinib       644241 Everolimus       6442177 Vicenistatin       6438888 Irinotecan       60838 Gemcitabine       60750 Topotecan       60700 (2-(Phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)       57339144 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea       56962337 [(3R,5S)-5-[2-[4-[[1-[(2,5-Difluorophenyl)methyl]indol-5-yl]amino]thieno[3,2-d]pyrimidin-6-yl]ethynyl]pyrrolidin-3-yl] morpholine-4-carboxylate;2,2,2-trifluoroacetic acid       56604049 Fumagillin dicyclohexylamine salt       5474187 Thiram       5455 Temozolomide       5394 Bleomycin a2       5360373 N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide       53340664 Palbociclib       5330286 1-[3-[2-(5-Ethylsulfonyl-2-methoxyanilino)-1,3-oxazol-5-yl]phenyl]ethanone       5329868 Vorinostat       5311 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide       5113032 Tubastatin A       49850262 Alectinib       49806720 2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432 3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626 2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine       46224516 N-(6,6-Dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide       46191454 N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912 1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine       44551660 3-(2-(4-(4-(3-Fluorobenzyloxy)-3-chlorophenylamino)pyrimidin-5-yl)ethynyl)-N-methylbenzamide       44410704 Staurosporine       44259 Gnidimacrin (G-1)       429314 (2S)-2-[[2-(2,3-Dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-6-purinyl]amino]-3-phenyl-1-propanol       42623900 Stereoisomer of NSC 674066-O       384359 2-(2-(Dimethylamino)ethylamino)naphthazarin       376950 Nilacrone       364456 4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one       364364 1-Naphthalenecarboxamide,N'-1,8-(octanediyl)bis-       364097 Paclitaxel       36314 3,5-Dimethyl-1-nitroso-2,6-diphenyl-4-piperidinone       362605 3-Nitro-5-formylisoxazole       362479 4-N,N-Bis-2'-cyanoethylaminobenzylidene-4-fluoro aniline       359414 Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)-       355940 5-Fluorouracil       3385 Phomazarin       318385 Thymolphthalein       31316 Isopropyltriphenylphosphonium bromide       2795292 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol       25262965 2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557 2-{[2-({5-[2-(Dimethylamino)acetamido]-2-methoxy-4-methylphenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluorobenzamide       25211574 Ruxolitinib       25126798 Tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate       24951314 Quizartinib       24889392 Vismodegib       24776445 4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860 Ethoxytris(2-methyl-8-chinolineolato)titanium(IV)       24202327 Vincaleukoblastine       241903 6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride       21701565 Lenalidomide       216326 Allyltriphenylphosphonium bromide       197740 Adiantifoline       167937 4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide       16747388 Gsk-690693       16725726 Fedratinib       16722836 Butyltriphenylphosphonium bromide       159628 Docetaxel       148124 7-Epi-10-deacetyltaxol       14355298 CID 13892272       13892272 (Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062 Roseophilin, HCl salt       135499311 (E)-5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime       135421339 Pac-1       135421197 Tert-Butyl (2,4-dioxo-2H-chromen-3(4H)-ylidene)methylcarbamate       135409213 Osi-027       135398516 Akt inhibitor VIII       135398501 Methotrexate       126941 Veliparib       11960529 N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-YL)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide       11754511 Trametinib       11707110 4-[2-(2-Chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide       11634725 Benzamide, 4-((1R)-1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, hydrochloride (1:1)       11507964 5-(2-Phenylpyrazolo[1,5-A]pyridin-3-YL)-1H-pyrazolo[3,4-C]pyridazin-3-amine       11493598 Linifanib       11485656 N-[4-(2-Tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide       11455910 N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide       11373846 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide       11338033 4-(4-Fluorophenyl)-5-(1,5-naphthyridin-2-yl)thiazol-2-amine       11290221 Amuvatinib       11282283 (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667 7-Ethyl-10-hydroxycamptothecin       104842 VX-702       10341154 Selumetinib       10127622 Masitinib       10074640 1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion       - 1,4-benzenediamine (9ci), n-butyl-n'-phenyl-       - ;3-amino-N-(3-(trifluoromethyl)phenyl)-6,7,8,9-tetrahydr...       - ;5,6-dichloro-2-(3-(4-methoxyphenyl)imidazo[1,5-a]pyridi...       - Bleomycin (50 uM)       - Cisplatin       - crotoxin cd       - ;(E)-5-chloro-3-((6-(4-chlorophenyl)-2-cyclopropylimidaz...       - Genentech Cpd 10       - indole-2,3-dione, 3-[(o-nitrophenyl)hydrazone]       - indole-2,3-dione, 7-methyl-, 3-[(o-nitrophenyl)hydrazone]       - JW-7-24-1       - KIN001-236       - KIN001-244       - KIN001-260       - KIN001-266       - KIN001-270       - MPS-1-IN-1       - NPK76-II-72-1       - protein toxin c 10 - mw approx. 6700       - QL-X-138       - QL-XI-92       - rTRAIL       - SB52334       - THZ-2-102-1       - THZ-2-49       - TL-1-85       - TL-2-105       - toxin .delta.53l       - tp4ek       - VNLG/124       - WZ3105       - XMD13-2       - XMD14-99       - XMD15-27       - ;(Z/E)-2-((5-(3,4-dimethoxyphenyl)-4-phenyl-4H-1,2,4-tri...       -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-497-5p
Interactor2: DLEU1

Evidence Support:

Weak-Evidence	Small RNA sequencing
Prediction-Evidence	miRNet
Support Database	ViRBase

References:

PMID	33045840	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	PBMC cells	Interactor2 expression	Downregulation
Description	FIG. 2.(B) upregulated miRNAs with their predicted downregulated gene targets.