Detail Information

Basic Information:


  VIRBase ID:  

HHID00096359

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-99b-5p:           TRIB2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-99b-5p TRIB2
miRBase
Accession/Entrez ID		 MIMAT0000689 28951
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C5FW//GS3955//TRB2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-99b-5p
rs1009295865 chr19:51692631    G/A
rs1262903983 chr19:51692618    C/T
rs1431437202 chr19:51692633    C/A
rs1431437202 chr19:51692633    C/T
rs1458889403 chr19:51692628    A/T
rs1474818571 chr19:51692627    A/T
rs1480721720 chr19:51692636    T/C
rs768225961 chr19:51692639    G/A
rs771967356 chr19:51692630    C/T
rs774985687 chr19:51692638    C/A
rs774985687 chr19:51692638    C/T
rs745644045 chr19:51692623    G/A
rs757194245 chr19:51692619    A/C
rs779007561 chr19:51692622    C/G
rs779007561 chr19:51692622    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRIB2
chr2:12857468-12857469(+) m6A 5'UTR//exon//intron       25456834//22608085
chr2:12857500-12857501(+) m6A 5'UTR//exon//intron       25456834
chr2:12857920-12857921(+) m6A 5'UTR//intron       24209618//25456834
chr2:12857969-12857970(+) m6A 5'UTR//intron       24209618//25456834
chr2:12857998-12857999(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085
chr2:12858007-12858008(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085
chr2:12858130-12858131(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085
chr2:12858199-12858200(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085
chr2:12858223-12858224(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085
chr2:12858437-12858438(+) m6A CDS//intron       24981863//22608085
chr2:12858488-12858489(+) m6A CDS//intron       24209618//24981863//22608085
chr2:12858493-12858494(+) m6A CDS//intron       24209618//24981863//22608085
chr2:12858557-12858558(+) m6A CDS//intron       24209618//24981863//22608085
chr2:12858583-12858584(+) m6A CDS//intron       24209618//24981863//22608085
chr2:12858590-12858591(+) m6A CDS//intron       24209618//24981863//22608085
chr2:12858636-12858637(+) m6A CDS//intron       24209618
chr2:12858650-12858651(+) m6A CDS//intron       24209618
chr2:12863484-12863485(+) m6A 5'UTR//CDS       24209618
chr2:12863521-12863522(+) m6A 5'UTR//CDS       25456834//24981863
chr2:12863576-12863577(+) m6A CDS       24209618//25456834//24981863//22608085
chr2:12863638-12863639(+) m6A CDS       24209618//25456834//24981863//22608085
chr2:12880561-12880562(+) m6A CDS       24209618//25456834//24981863//22608085
chr2:12880661-12880662(+) m6A CDS       24209618//25456834//24981863//22608085
chr2:12880713-12880714(+) m6A CDS       24209618//25456834//24981863//22608085
chr2:12880798-12880799(+) m6A CDS       24209618//25456834//24981863//22575960//22608085
chr2:12880897-12880898(+) m6A CDS       24209618//25456834//24981863//22608085
chr2:12880903-12880904(+) m6A CDS       24209618//25456834//24981863//22608085
chr2:12880937-12880938(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr2:12880991-12880992(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr2:12881022-12881023(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr2:12881057-12881058(+) m6A 3'UTR       24209618//25456834//24981863//22608085
chr2:12881171-12881172(+) m6A 3'UTR       24209618//25456834//24981863//22608085
chr2:12881255-12881256(+) m6A 3'UTR       24209618

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-99b-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|Breast milk|Endothelial cells|Epithelial cells|Kidney tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
TRIB2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-99b-5p
Piperidine, 2-methyl-6-undecyl- 99090 Drug resistant
2-(2,4-Difluorophenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione 9905583 Drug resistant
S-Decyl p-toluenethiosulfonate 97461 Drug resistant
5-Iodo-8-quinolinol 96111 Drug resistant
Actinomycin X4357G methoxime 9573583 Drug resistant
[(1R,2Z,4R,8R,9R,11R,12S)-1,12-Dihydroxy-2-(hydroxymethyl)-11-methyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (Z)-2-methylbut-2-enoate 90475906 Drug resistant
[(1R,2S,6R,7R,9S,12S,13S)-13-(Acetyloxymethyl)-12-hydroxy-9-methyl-5-methylidene-4-oxo-3,14-dioxatricyclo[7.4.1.02,6]tetradecan-7-yl] (Z)-2-(acetyloxymethyl)but-2-enoate 90473692 Drug resistant
Acid Green 27 80837 Drug resistant
Jacaranone 73307 Drug resistant
Piperidinium pentamethylenedithiocarbamate 72508 Drug resistant
7-Hydroxystaurosporine 72271 Drug resistant
Vicenistatin 6438888 Drug resistant
Tributyrin 6050 Drug resistant
Liatris laevigata lactone #2 5477810 Drug resistant
Caracemide 54747 Drug resistant
7Z-Plakortide H 5472712 Drug resistant
3-Deazauridine 54684286 Drug resistant
9-alpha-Acetoxyparthenolide 54611286 Drug resistant
p-Chloranilinum[bis(p-chloraniline)dioxalatoruthenate(III)] 54608061 Drug resistant
Antineoplastic-651590 54604785 Drug resistant
(E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug resistant
Ovatifolin acetate 5358419 Drug resistant
N,N-Dimethyldaunomycin hydrochloride 5351276 Drug resistant
N-(5-Ethylsulfonyl-2-methoxyphenyl)-5-[3-(2-fluorophenyl)phenyl]-1,3-oxazol-2-amine 5329875 Drug sensitive
Herbimycin 5311102 Drug resistant
Improsulfan hydrochloride 5284401 Drug resistant
Cyclosporin A 5284373 Drug resistant
Erioflorin acetate 5281443 Drug resistant
Ammonia; dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498559 Drug resistant
Patulin 4696 Drug resistant
1,4-Phenanthrenedione, 10-(formyloxy)-4b,5,6,7,8,8a,9,10-octahydro-3,9-dihydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS,9S,10S)- 462176 Drug resistant
L-Cysteine analog 457392 Drug resistant
Fastigilin B 442241 Drug resistant
Elephantin 442205 Drug resistant
Oridonin (thiol adduct OF) 432952 Drug resistant
10-Hydroxy-5-methoxy-1-(2-methyloxiran-2-yl)-1,2-dihydrofuro[2,3-c]xanthen-6-one 429905 Drug resistant
2,5-Bis(aziridin-1-yl)-3-(hydroxymethyl)-6-methylcyclohexa-2,5-diene-1,4-dione 394347 Drug resistant
2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug resistant
3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug sensitive
Stereoisomer of NSC 674066-O 384359 Drug resistant
N8-Actinomycin D 383040 Drug resistant
7-Chloro-6-(2-fluoroethylamino)quinoline-5,8-dione 379079 Drug resistant
3,8-Dimethyl-1,2-naphthoquinone 373912 Drug resistant
Benzoxazole, 2-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]- 364608 Drug resistant
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one 364364 Drug sensitive
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug resistant
3-Deazaneplanocin hydrochloride 358176 Drug resistant
Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug sensitive
2-Isopropenyl-4,6-diphenoxy-1,3,5-triazine 340916 Drug resistant
4-Ethyl-6-methoxy-7-(oxiran-2-ylmethoxy)quinazoline 333565 Drug resistant
Dmask 32465 Drug resistant
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug resistant
1,1-Dimethyl-5-(2-naphthalenyl)dithiobiuret 3004012 Drug resistant
2,3-Bis(iodomethyl)-6-methoxyquinoxaline 286257 Drug resistant
Dichloroallyl lawsone 277767 Drug resistant
N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug resistant
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug resistant
2,4,6-Trichloro-5-methylpyrimidine 232789 Drug resistant
Diethylcarbamodithioic acid, sodium salt 21192315 Drug resistant
(1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 20835084 Drug resistant
4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug resistant
Aklavin 149755 Drug resistant
Bis(triethylphosphine)gold(I) chloride 149280 Drug resistant
N-[3-[(3-Amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl]-2-[(1S)-18-[(2S)-2,3-dihydroxybutan-2-yl]-11-ethylidene-59-hydroxy-8,31-bis(1-hydroxyethyl)-26,46-dimethyl-40,43-dimethylidene-6,9,16,23,28,38,41,44,47-nonaoxo-37-propan-2-yl-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecazanonacyclo[23.23.9.329,35.12,5.112,15.119,22.154,57.01,53.032,60]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazole-4-carboxamide 146156820 Drug resistant
Methyl 3-bromo-2-(bromomethyl)propionate 140895 Drug resistant
Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug resistant
C8, Carbonyl prodigiosine 135540857 Drug resistant
Cysteine, S-[(4-aminocarbonyl-1H-imidazol-5-yl)azo]- 135493928 Drug resistant
8-Azahypoxanthine 135410720 Drug resistant
Mercury, (4-aminophenyl)(6-thioguanosinato-N7,S6)- 135403617 Drug resistant
DTIC-Dome 135398738 Drug resistant
Sendanin 12806435 Drug resistant
Dibutyltin dichloride 12688 Drug resistant
Acetylenedicarboxamide 10971 Drug resistant
Erigerol 101318126 Drug resistant
(1s,2e,4r,7e,11e)-4-hydroxy-2,7,11-cembratrien-6-one - Drug resistant
(E)-2-(2-(benzo[d][1,3]dioxol-5-yl)vinyl)-5-(3-methyl-1H-pyrazol-5-yl)-1,3,4-oxadiazole - Drug resistant
1,1'-biphenyl, 4,4'bis(thiomethyl)- - Drug resistant
1h-1,2,4-triazole, 3-(4-diazo-4h-imidazol-5-yl)- - Drug resistant
2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug resistant
4(1h)-quinazolinone, 2-(2-chlorophenyl)-2,3-dihydro- - Drug resistant
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug resistant
4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug resistant
4-morpholinecarbodithioic acid, antimony complex - Drug resistant
4-piperidinone, 3,5-bis[(4-fluorophenyl)methylene]-, (e,e)- - Drug resistant
4-quinazolone, 7-amino-3-(4-methoxyphenyl)-, hydrate - Drug resistant
4-thiomorpholinecarbodithioic acid, antimony complex - Drug resistant
7h-5,6-dithioleno[4,3-d]uracil - Drug resistant
9,10-anthracenedione, 1-[(oxiranylmethyl)amino]- - Drug resistant
b676297k277 3',4'-deoxypsorospermin 3',4'-chlorohydrin - Drug resistant
cyclopentanone, 2,5-bis[(trimethylamino)methyl]-, iodide - Drug resistant
dimethylarsinothious acid, 2,4-pyrimidinediyl ester - Drug resistant
ethyl, methoxy, prodigisine - Drug resistant
n,n'-bis(oxydiethylene)thiocarbamoylsulfenamide - Drug resistant
propan-1-one, 2,3-dichloro-1,3-bis(4-methylphenyl)- - Drug resistant
propanedinitrile, [(3,5-dibromo-2-ethoxyphenyl)methylene]- - Drug resistant
pyrimidine, 2,4,5-trichloro-6-ethyl- - Drug resistant
pyrimidine, 2,4,5-trichloro-6-isopropyl- - Drug resistant
[bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug resistant
antineoplastic-624657 - Drug resistant
Copper(II) complex with quin as a ligand - Drug resistant
geldanamycin analog - Drug resistant
hymenialdisine - Drug resistant
maleimide carbazole - Drug resistant
Methotrexate Derivative - Drug resistant
n-acetyl-4-s-cystaminyl phenol - Drug resistant
o-linoleoyl-2-butoxy-1-desoamine - Drug resistant
potassium[trichloro(isopropylamine)platinum] - Drug resistant
somatostatin analog in diacetic form mw=1067.2 - Drug resistant
streptorubrin - Drug resistant
thiadiazines - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
1-naphthalenecarboxamide, n,n'-1,8-(octanediyl)bis- - Drug sensitive
6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug sensitive
antineoplastic-d655481 - Drug sensitive
toxin .delta.53l - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-99b-5p
10-Hydroxycamptothecin 97226 Drug interaction    RC00003955
Hyaluronidase 91820602 Drug interaction    RC00003965
Cianidanol 9064 Drug interaction    RC00003950
Gemcitabine 60750 Drug interaction    RC00003954
Vincristine 5978 Drug interaction    RC00003949
Mitomycin 5746 Drug interaction    RC00003948
Ascorbic acid 54670067 Drug interaction    RC00003964
Vorinostat 5311 Drug interaction    RC00003947
Eloxatine 5310940 Drug interaction    RC00003963
Morphine 5288826 Drug interaction    RC00003962
Cholecalciferol 5280795 Drug interaction    RC00003961
Quercetin 5280343 Drug interaction    RC00003960
Carboplatinum 38904 Drug interaction    RC00003953
Ifosfamide 3690 Drug interaction    RC00003946
Paclitaxel 36314 Drug interaction    RC00003952
5-Fluorouracil 3385 Drug interaction    RC00003945
Doxorubicin 31703 Drug interaction    RC00003951
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003944
Tamoxifen 2733526 Drug interaction    RC00003959
Sorafenib 216239 Drug interaction    RC00003958
Docetaxel 148124 Drug interaction    RC00003957
Proanthocyanidin 108065 Drug interaction    RC00003956
Marine fungal metabolite 1386A - Drug interaction    RC00003968
Glucocorticoid - Drug interaction    RC00003967
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003966
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-99b-5p
Cisplatin 5702198       25356050
5-Fluorouracil 3385       25356050
Doxorubicin 31703       24759738
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       24759738

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-99b-5p
Interactor2: TRIB2

Evidence Support:


Weak-Evidence Small RNA sequencing
Prediction-Evidence miRNet
Support Database ViRBase

References:


PMID 33045840 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line PBMC cells Interactor2 expression Downregulation
Description FIG. 2.(B) upregulated miRNAs with their predicted downregulated gene targets.

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