Detail Information

Basic Information:


  VIRBase ID:  

HHID00096347

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-185-5p:           CXCL8:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-185-5p CXCL8
miRBase
Accession/Entrez ID		 MIMAT0000455 3576
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - GCP-1//GCP1//IL8//LECT//LUCT//LYNAP//MDNCF//MONAP//NAF//NAP-1//NAP1//SCYB8

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-185-5p
rs1249170072 chr22:20033164    G/A
rs770235403 chr22:20033168    T/C
rs775856637 chr22:20033173    G/A
rs1398989482 chr22:20033154    G/A
rs761385932 chr22:20033159    GAA/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CXCL8
chr4:74606289-74606290(+) m6A 5'UTR//exon       24981863//26404942
chr4:74606299-74606300(+) m6A 5'UTR//exon       24981863//26404942
chr4:74606324-74606325(+) m6A 5'UTR//exon       24981863//26404942//27773535
chr4:74606341-74606342(+) m6A 5'UTR//exon       24981863//26404942//27773535
chr4:74606354-74606355(+) m6A 5'UTR//exon       24981863//26404942//27773535
chr4:74606373-74606374(+) m6A 5'UTR//exon       24981863//26404942//27773535
chr4:74607286-74607287(+) m6A CDS//exon       27773535
chr4:74607308-74607309(+) m6A CDS//exon       27773535
chr4:74607319-74607320(+) m6A CDS//exon       26404942//27773535
chr4:74607346-74607347(+) m6A CDS//exon       26404942//27773535
chr4:74607367-74607368(+) m6A CDS//exon       26404942//27773535
chr4:74607434-74607435(+) m6A exon//intron       26404942
chr4:74608331-74608332(+) m6A 3'UTR       27773535
chr4:74608370-74608371(+) m6A 3'UTR       27773535
chr4:74608413-74608414(+) m6A 3'UTR       27773535
chr4:74608510-74608511(+) m6A 3'UTR       26404942//27773535
chr4:74608579-74608580(+) m6A 3'UTR       26404942//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-185-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Plasma     29130611
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Serum     25135963
Exosome Blood|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
CXCL8
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-185-5p
7-Epi-10-deacetylbaccatin III 9872117 Drug sensitive
Midostaurin 9829523 Drug resistant
Tiotixene 941651 Drug sensitive
Acridine Yellow G 8672 Drug resistant
1,9-Pyrazoloanthrone 8515 Drug resistant
Pingyangmycin 84046 Drug resistant
Tanakan 83818 Drug sensitive
2,4,6-Tris(2-pyridyl)-s-triazine 77258 Drug sensitive
Secalonic acid D 73431 Drug sensitive
Coptisine chloride 72321 Drug sensitive
7-Hydroxystaurosporine 72271 Drug resistant
Anaxirone 71218 Drug resistant
Dihydroxydiphenyl-pyridyl methane 69046 Drug resistant
Mevastatin 64715 Drug resistant
Everolimus 6442177 Drug resistant
Primaquine phosphate 6135 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
Thiopyrimidine-CH3 5473238 Drug sensitive
Iejimalide A. 5473233 Drug sensitive
11-Cyanomethylen-11H-indolo[1,2-a]indazole 5472501 Drug resistant
6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive
Bleomycin 5460769 Drug resistant
Herveline O 5459269 Drug sensitive
[2-[2-[(1R,2S)-2-[[6-Amino-2-[1-[(2S)-2,3-diamino-3-oxopropyl]-4-oxoazetidin-2-yl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[(2R,3S,4S)-3-hydroxy-5-[[(2S,3R)-3-hydroxy-1-[2-[4-[4-[2-(2-hydroxypropylamino)ethylcarbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-1-oxobutan-2-yl]amino]-4-methyl-5-oxopentan-2-yl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate 5458321 Drug resistant
Melampodin B acetate 5359212 Drug sensitive
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
Lovastatin 53232 Drug resistant
Cytochalasin B 5311281 Drug resistant
Herbimycin 5311102 Drug sensitive
5-Fluoro-2'-deoxycytidine 515328 Drug resistant
Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 4713 Drug sensitive
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
3-3'-(1H-Pyrazole-3,5-diyl)bis(1-methyl-1H-indole) 44433919 Drug resistant
4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine 44397453 Drug resistant
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive
Bleomycin-BAPP 431594 Drug resistant
Bleomycin A5, sulfate 422920 Drug resistant
Aminopyrimidine-CH3 406278 Drug sensitive
1H-Naphth[2,3-d]imidazole, 2-[(4-chlorophenyl)methyl]- 405626 Drug resistant
Purpureagitosid 401298 Drug resistant
Trapoxin B 395803 Drug sensitive
3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-(3-Chloropropyloxy)naphthazarin 378771 Drug sensitive
5,8-Dihydroxy-2-(4-(2-pyridinyl)-1-piperazinyl)naphthoquinone 376947 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
2,3-Bis(dodecanoyloxy)propylarsonic acid 375754 Drug sensitive
Naphtho[2,3-f]quinoxaline-7,12-dione, 3-hydroxy-2-methyl- 371563 Drug resistant
1-(4-Methoxy-2-methylphenyl)naphtho[1,2-c]furan-3(1H)-one 369148 Drug sensitive
3,8,13,18,23-Pentaazapentacosane 368998 Drug sensitive
2,7-Dicyanoxanthone 363841 Drug sensitive
Girolline 362388 Drug resistant
1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)- 362170 Drug sensitive
7alpha-Acetoxyroylenane 362048 Drug sensitive
Thiosangivamycin 3580213 Drug sensitive
Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug resistant
2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug sensitive
1,4-Diaminoanthraquinone 31420 Drug resistant
Clomifene citrate 3033832 Drug sensitive
SMA-491 (free base of NSC D742838) 302576 Drug resistant
Gardenin A 261859 Drug resistant
Hookerianamide J 25016666 Drug sensitive
Hookerianamide K 25016412 Drug sensitive
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive
CID 24197685 24197685 Drug sensitive
Antibiotic U 29135 24196291 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Chonemorphine 165208 Drug sensitive
(6R)-1,6,11-Trihydroxy-8-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-3-methyl-5,6-dihydrobenzo[a]anthracene-7,12-dione 15507920 Drug sensitive
Ellipticine analog 148569 Drug resistant
(2R)-2-Hydroxy-3-[(6R)-11-hydroxy-2-[4-[(6R)-4-hydroxy-2-[1-hydroxy-3-[(6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-methylpropanoic acid 146158002 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
[(8Ar)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoate 134694047 Drug resistant
Methyl (1S,10R,11S,12S)-11-acetyloxy-12-ethyl-4-[(13R,15R,17R)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 133126830 Drug sensitive
(2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug sensitive
1,4-Bis((2-aminoethyl)amino)-5,8-dihydroxy-9,10-anthraquinone 125982 Drug resistant
Pepleo 122804 Drug resistant
Cyanoaminopyranopyridine derivatives 11494577 Drug resistant
1-Phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole 11162021 Drug resistant
Uridine, 2'-deoxy-2'-methylene- 11075548 Drug resistant
Acetylenedicarboxamide 10971 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
Binimetinib 10288191 Drug sensitive
(1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive
Selumetinib 10127622 Drug sensitive
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant
1-naphthalenecarboxamide, n,n'-1,8-(octanediyl)bis- - Drug resistant
6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant
3-peg fudr (peg floxuridine) - Drug resistant
6-aryl alkyl fluoro quinolone derivative - Drug resistant
Annamycin Liposomal - Drug resistant
antineoplastic-d655481 - Drug resistant
Camptothecin Derivative - Drug resistant
geldanamycin dimethylglycinate - Drug resistant
organosulfur compound - Drug resistant
tartrolon a1 - Drug resistant
toxin .delta.53l - Drug resistant
tp4ek - Drug resistant
viridomycin - Drug resistant
(z) 3,3',4,5-tetramethoxystilbene - Drug sensitive
1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt - Drug sensitive
1-piperidinecarbodithioic acid, antimony complex - Drug sensitive
2-azabicyclo[16.3.1]docosane, geldanamycin deriv. - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
5,6-dimethyl-9-oxo-9h-xanthene-4-acetic acid, sodium salt - Drug sensitive
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive
5-hydroxyamino camptothecin - Drug sensitive
antineoplastic-615538 - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
geldanamycin deriv - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
xenorhabdin 1 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-185-5p
Formaldehyde 712 Drug interaction    RC00003208
Oxaliplatine 6857599 Drug interaction    RC00003218
Gemcitabine 60750 Drug interaction    RC00003213
Cholesterol 5997 Drug interaction    RC00003211
Eloxatine 5310940 Drug interaction    RC00003217
Decitabine 451668 Drug interaction    RC00003215
5-Fluorouracil 3385 Drug interaction    RC00003210
Doxorubicin 31703 Drug interaction    RC00003212
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003209
Tamoxifen 2733526 Drug interaction    RC00003216
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00003219
Benzene 241 Drug interaction    RC00003207
Leucovorin 135403648 Drug interaction    RC00003220
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-185-5p
Cisplatin 5702198       27906433
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-185-5p
Interactor2: CXCL8

Evidence Support:


Weak-Evidence Small RNA sequencing
Prediction-Evidence miRNet
Support Database ViRBase

References:


PMID 33045840 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line PBMC cells Interactor2 expression Downregulation
Description FIG. 2.(B) upregulated miRNAs with their predicted downregulated gene targets.

Starting a new search, please wait ...