Detail Information

Basic Information:


  VIRBase ID:  

HHID00096333

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9751

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-125a-5p:           IFITM3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-125a-5p IFITM3
miRBase
Accession/Entrez ID		 MIMAT0000443 10410
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - 1-8U//DSPA2b//IP15

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-125a-5p
rs755486470 chr19:51693290    G/A
rs12975333 chr19:51693275    G/T
rs1384918474 chr19:51693273    G/A

RNA Editing:


Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED IFITM3
chr11:320606(-) C-A intron -    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IFITM3
chr11:319919-319920(-) m6A 3'UTR//CDS       27773535//22575960
chr11:320211-320212(-) m6A CDS//intron       27773535//22575960
chr11:320607-320608(-) m6A CDS       24284625//24981863//27773535//27371828//22575960
chr11:320659-320660(-) m6A CDS       24284625//24981863//27773535//27371828//22575960
chr11:320794-320795(-) m6A CDS//intron       24284625//24981863//27773535//27371828//22575960
chr11:320817-320818(-) m6A 5'UTR//intron       24284625//24981863//27773535//27371828//22575960
chr11:320855-320856(-) m6A 5'UTR//intron       24284625//25456834//24981863//27773535//22575960
chr11:320885-320886(-) m6A 5'UTR//intron       24284625//25456834//24981863//27773535
chr11:320891-320892(-) m6A 5'UTR//intron       24284625//25456834//24981863//27773535
chr11:320902-320903(-) m6A 5'UTR//intron       24284625//25456834//24981863//27773535
chr11:325736-325737(-) m6A intron       -
chr11:325749-325750(-) m6A intron       -
chr11:325819-325820(-) m6A intron       -
chr11:325826-325827(-) m6A intron       -
chr11:325843-325844(-) m6A intron       -
chr11:325876-325877(-) m6A intron       -
chr11:325883-325884(-) m6A intron       -
chr11:325943-325944(-) m6A intron       -
chr11:325950-325951(-) m6A intron       -
chr11:326010-326011(-) m6A intron       -
chr11:326017-326018(-) m6A intron       -
chr11:326065-326066(-) m6A intron       27773535
chr11:326080-326081(-) m6A intron       27773535
chr11:326116-326117(-) m6A intron       27773535
chr11:326133-326134(-) m6A intron       27773535
chr11:326139-326140(-) m6A intron       27773535
chr11:326149-326150(-) m6A intron       27773535
chr11:326175-326176(-) m6A intron       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-125a-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Blood|Breast milk|Endothelial cells|Epithelial cells|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Hepatoma cells     23771658
Microvesicle Serum     24797360
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Myotube     27396686
Mitochondrion Skeletal muscle cells     27563705
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus HeLa cells     23940654
Nucleolus Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
IFITM3
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-125a-5p
Curcumin 969516 Drug interaction    RC00003034
Hyaluronidase 91820602 Drug interaction    RC00003036
Gemcitabine 60750 Drug interaction    RC00003029
Vincristine 5978 Drug interaction    RC00003024
Imatinib 5291 Drug interaction    RC00003023
Decitabine 451668 Drug interaction    RC00003033
Epirubicin 41867 Drug interaction    RC00003028
Paclitaxel 36314 Drug interaction    RC00003027
5-Fluorouracil 3385 Drug interaction    RC00003022
Doxorubicin 31703 Drug interaction    RC00003026
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003021
Tamoxifen 2733526 Drug interaction    RC00003035
Arsenic trioxide 14888 Drug interaction    RC00003025
Docetaxel 148124 Drug interaction    RC00003032
Gefitinib 123631 Drug interaction    RC00003031
Trastuzumab - Drug interaction    RC00003037
Glucocorticoid - Drug interaction    RC00003038
Marine fungal metabolite 1386A - Drug interaction    RC00003039
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-125a-5p
Cisplatin 5702198       25356050
Cisplatin 5702198       29767234
Imatinib 5291       25349971
Imatinib 5291       30249101
5-Fluorouracil 3385       25356050
Doxorubicin 31703       24759738
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       24759738
Cetuximab -       26107137
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-125a-5p
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-125a-5p
Interactor2: IFITM3

Evidence Support:


Strong-Evidence ELISA//qRT-PCR//TaqMan qRT-PCR
Weak-Evidence Microarray
Support Database ViRBase

References:


PMID 20436668 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HIV-infected cells Interactor2 expression Upregulation
Description We found that IFITM3 protein decreased in response to miR125a overexpression at 3-5 days of post-miR125a induction, Figure 6a. We have therefore provided in vitro evidence that miR-125a can alter protein levels of IFITM3 in primary human neuronal cultures.

Starting a new search, please wait ...