Detail Information

Basic Information:


  VIRBase ID:  

HHID00096277

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-192-5p:           ZMAT3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-192-5p ZMAT3
miRBase
Accession/Entrez ID		 MIMAT0000222 64393
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PAG608//WIG-1//WIG1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-192-5p
rs1200157992 chr11:64891207    G/A
rs1319751380 chr11:64891223    G/C
rs1429951226 chr11:64891208    T/C
rs1432151706 chr11:64891210    A/G
rs1479738427 chr11:64891215    A/T
rs745921297 chr11:64891197    AGCACTG/A
rs1172396861 chr11:64891217    A/T
rs1342858704 chr11:64891218    G/T
rs750158178 chr11:64891220    T/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZMAT3
chr3:178748281(-) A-I      intronic
chr3:178748303(-) A-I      intronic
chr3:178748370(-) A-I      intronic
chr3:178749576(-) A-I      intronic
chr3:178749657(-) A-I      intronic
chr3:178782333(-) A-I      intronic
chr3:178782438(-) A-I      intronic
chr3:178782514(-) A-I      intronic
chr3:178746785(-) A-I      intronic
chr3:178746826(-) A-I      intronic
chr3:178746908(-) A-I      intronic
chr3:178782498(-) A-I      intronic
chr3:178782315(-) A-I      intronic
chr3:178749529(-) A-I      intronic
chr3:178749503(-) A-I      intronic
chr3:178782320(-) A-I      intronic
chr3:178748319(-) A-I      intronic
chr3:178749515(-) A-I      intronic
chr3:178749573(-) A-I      intronic
chr3:178748414(-) A-I      intronic
chr3:178749583(-) A-I      intronic
chr3:178744351(-) A-I      intronic
chr3:178762265(-) A-I      intronic
chr3:178783601(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZMAT3
chr3:178740951(-) G-A exon 3'UTR    22484847
chr3:178744455(-) G-C intron -    22484847
chr3:178748414(-) A-G intron -    22484847
chr3:178749503(-) A-G intron -    22484847
chr3:178749515(-) A-G intron -    22484847
chr3:178749529(-) A-G intron -    22484847
chr3:178749573(-) A-G intron -    22484847
chr3:178749583(-) A-G intron -    22484847
chr3:178765486(-) G-T intron -    22484847
chr3:178778367(-) T-C intron -    22484847
chr3:178782498(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZMAT3
chr3:178738549-178738550(-) m6A 3'UTR       -
chr3:178738614-178738615(-) m6A 3'UTR       -
chr3:178742341-178742342(-) m6A 3'UTR       -
chr3:178748766-178748767(-) m6A CDS       24981863//27773535//22608085
chr3:178785301-178785302(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr3:178785321-178785322(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr3:178785361-178785362(-) m6A CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr3:178785388-178785389(-) m1A CDS       26863196
chr3:178785452-178785453(-) m6A CDS       24284625//24981863//22575960
chr3:178785588-178785589(-) m6A 5'UTR       -
chr3:178789557-178789558(-) m6A 5'UTR       25456834//24981863//27371828
chr3:178789819-178789820(-) m6A 5'UTR       27371828
chr3:178789857-178789858(-) m6A 5'UTR       27371828
chr3:178789948-178789949(-) m6A 5'UTR       24981863//27371828
chr3:178789957-178789958(-) m6A 5'UTR       24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-192-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Plasma     19289371
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Ovarian follicular fluid     22116803
Exosome Colorectal cancer cell lines (HCT-15|SW480|WiDr)     22895844
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
ZMAT3
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-192-5p
Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug sensitive
Piperidine, 2-methyl-6-undecyl- 99090 Drug sensitive
5-(5,6-Dimethoxy-1-benzimidazolyl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide 9826308 Drug sensitive
Gardenin B 96539 Drug sensitive
Tiotixene 941651 Drug sensitive
4-(1,3-Benzoxazol-2-yl)aniline 88733 Drug sensitive
Pingyangmycin 84046 Drug resistant
2-(Benzyloxy)-4-methoxybenzaldehyde 820527 Drug resistant
Vancide 26 79411 Drug sensitive
10,11-Methylenedioxy-20S-camptothecin 72403 Drug resistant
Temsirolimus 6918289 Drug resistant
Dihydroxydiphenyl-pyridyl methane 69046 Drug resistant
3,6-Diamino-10-methylacridinium chloride 6842 Drug sensitive
4'-Chloro-3-hydroxy-2'-methyl-2-naphthanilide 66718 Drug resistant
Methylestradiol 66413 Drug sensitive
Fludarabine 657237 Drug resistant
N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive
Tanespimycin 6505803 Drug sensitive
Everolimus 6442177 Drug resistant
Vicenistatin 6438888 Drug sensitive
Mastoparan 6324633 Drug resistant
Irinotecan 60838 Drug resistant
Gemcitabine 60750 Drug resistant
Topotecan 60700 Drug resistant
3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug sensitive
Cisplatin 5702198 Drug resistant
Thiopyrimidine-CH3 5473238 Drug sensitive
Iejimalide A. 5473233 Drug sensitive
7Z-Plakortide H 5472712 Drug sensitive
(8R,9S,13S,14S,17S)-13-Methyl-2-[(E)-prop-1-enyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol 5468270 Drug resistant
Trimethyl 2-phosphono-3-(2-furan)acrylate 5467926 Drug resistant
p-Chloranilinum[bis(p-chloraniline)dioxalatoruthenate(III)] 54608061 Drug sensitive
Bleomycin 5460769 Drug resistant
Selendale 54601159 Drug resistant
Aspiculamycin hcl 54600418 Drug resistant
Herveline O 5459269 Drug sensitive
Ternatin 5459184 Drug resistant
Cuspidatin C 5459164 Drug sensitive
Trunculin A 5459125 Drug sensitive
Xestin A 5352066 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
Hydroxy AT 125 5351254 Drug sensitive
3-[(4-Methoxyphenyl)thio]-2H-isoindole-1-carbaldehyde 53361730 Drug sensitive
3-[1-(2-Chlorophenyl)ethoxy]-5-(6-methoxybenzimidazol-1-yl)thiophene-2-carboxamide 53338698 Drug sensitive
5-(6-Methoxybenzimidazol-1-yl)-3-[1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide 53338692 Drug sensitive
5-[6-[(1-Methylpiperidin-4-yl)methoxy]benzimidazol-1-yl]-3-[1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide 53338689 Drug sensitive
Lovastatin 53232 Drug resistant
Sirolimus 5284616 Drug resistant
Methoxycamptothecin 494089 Drug resistant
Melphalan 460612 Drug resistant
o6-Benzylguanine 4578 Drug resistant
Neriifolin 441867 Drug resistant
Triciribine phosphate 43860 Drug resistant
Ditercalinium dimethanesulfonate dimethanesulfonate 435243 Drug sensitive
Bleomycin-BAPP 431594 Drug resistant
Carboplatin 426756 Drug resistant
Diaziquone 42616 Drug resistant
5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug resistant
Aminopyrimidine-CH3 406278 Drug sensitive
3-Acetoxymethyl-1-methyl-5-methoxyindole-4,7-dione 404937 Drug sensitive
Triacetyl crambescidin 800 hydrochloride 400721 Drug sensitive
1,2 Benzo-8-(1-hydroxy-2-methylamino propane)-3-phenoxazone 400530 Drug resistant
1-(4'-Phthalimidopropyl-carbonyl)-5-fluorouracil 388985 Drug sensitive
Stereoisomer of NSC 674066-O 384359 Drug sensitive
2-Ethenyl estradiol 381026 Drug resistant
Antineoplastic-655905 375758 Drug resistant
4-Methylthio-N-(3,4,5-trimethoxybenzyl)aniline 373808 Drug sensitive
Naphtho[2,3-f]quinoxaline-7,12-dione, 3-hydroxy-2-methyl- 371563 Drug resistant
Antineoplastic-645804 371505 Drug sensitive
1,2-Dimethyl-phenothiazone 369387 Drug resistant
1-(4-Methoxy-2-methylphenyl)naphtho[1,2-c]furan-3(1H)-one 369148 Drug sensitive
(4-Methoxyphenyl)-(3,4,5-trimethoxyphenyl)methanol 368140 Drug sensitive
4-N,N-Bis-2'-cyanoethylaminobenzylidene-4-fluoro aniline 359414 Drug sensitive
Gitoxigenin 348482 Drug resistant
Nordracorubin 341882 Drug sensitive
Zonarol 332671 Drug resistant
Rocaglamide 331783 Drug sensitive
12-Hydroxyindolo[2,1-b]quinazoline-6(12H)-one 324952 Drug resistant
Ellipticine 3213 Drug sensitive
Phomazarin 318385 Drug resistant
4-[3-[2-Chloro-4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenyl]propanoylamino]benzenesulfonyl fluoride;ethanesulfonic acid 276171 Drug sensitive
Tamoxifen 2733526 Drug sensitive
Chelerythrine 2703 Drug sensitive
1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug resistant
Gardenin A 261859 Drug resistant
3-[(1R)-1-(2-Chlorophenyl)ethoxy]-5-{6-[(2S)-2,3-dihydroxypropoxy]-1H-1,3-benzodiazol-1-yl}thiophene-2-carboxamide 25263120 Drug sensitive
3-[(1S)-1-(2-Chlorophenyl)ethoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide 25263117 Drug sensitive
3-[(2-Chlorophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide 25263092 Drug sensitive
3-[(2-Bromophenyl)methoxy]-5-[6-(trifluoromethyl)benzimidazol-1-yl]thiophene-2-carboxamide 25263088 Drug sensitive
5-(1H-1,3-Benzodiazol-1-yl)-3-[(2-bromophenyl)methoxy]thiophene-2-carboxamide 25263083 Drug sensitive
Camptothecin 24360 Drug resistant
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
4'-(1H-Benzimidazol-2-yl)1,1biphenyl-4-amine 24205338 Drug sensitive
2[4'Aminobiphenyl]5,6dichlorobenzimidazole 24205088 Drug sensitive
3-Bromo-4-(2-(4-methoxyphenyl)ethynyl)furan-2(5H)-one 24204187 Drug sensitive
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug sensitive
Antibiotic U 29135 24196291 Drug sensitive
N-Butyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 219760 Drug sensitive
3-Amino-N-(2-fluorophenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide 1856915 Drug sensitive
Verrucarin A 9,10-epoxide 181390 Drug sensitive
Erlotinib 176870 Drug resistant
Jolkinolide B 161954 Drug resistant
N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug resistant
Dibromsalan 14839 Drug resistant
4-Oxo-4-[[(13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]butanoic acid 146160078 Drug sensitive
Strospeside, 16-acetate (6CI,7CI,8CI); (3beta,5beta,16beta)-16-(Acetyloxy)-3-[(6-deoxy-3-O-methyl-beta-D-galactopyranosyl)oxy]-14-hydroxycard-20(22)-enolide 146158929 Drug resistant
Edelfosine 1392 Drug sensitive
Eriochrome black t 135465089 Drug resistant
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug resistant
Purpurogallin 135403797 Drug resistant
8-Azaguanine 135403646 Drug resistant
Triphenyltin chloride 12540 Drug sensitive
Octadecylphosphocholine 125219 Drug sensitive
Pepleo 122804 Drug resistant
Unii-6FH145297U 11541062 Drug resistant
Neoambrosin 11128594 Drug sensitive
Binimetinib 10288191 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
[(1R,3R,5R,8R,9S,10R,13R,14S,17R)-3-[(2R,3R,4R,5R,6S)-3,5-Dihydroxy-4-methoxy-6-methyloxan-2-yl]oxy-10,14-dihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-1-yl] acetate 101973931 Drug resistant
Selumetinib 10127622 Drug sensitive
N,N-Bis(2-chloroethyl)-p-toluidine 100400 Drug resistant
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug resistant
1-naphthalenecarboxamide, n,n'-1,8-(octanediyl)bis- - Drug resistant
6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, diacetate - Drug resistant
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug resistant
benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2,5-diacetyl- - Drug resistant
mercury, tetrakis(acetato)(2,3,4,5-thiophenetetrayl)tetra- - Drug resistant
naphtho[2,3-d]oxazole-4,9-dione, 2-(1,1-dimethylethyl)- - Drug resistant
phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug resistant
piceatannol, 4,3',5'-trimethyl,1s0 - Drug resistant
pyrazino[1,2-a]benzimidazole, 1,3-diphenyl- - Drug resistant
Aminocamptothecin - Drug resistant
Camptothecin Derivative - Drug resistant
Chlorozotocin - Drug resistant
crotoxin cd - Drug resistant
Cyanomorpholinodoxorubicin - Drug resistant
Indenoisoquinoline derivative - Drug resistant
potassium arsenite - Drug resistant
protein toxin a 23 - mw approx. 6700 - Drug resistant
protein toxin c 10 - mw approx. 6700 - Drug resistant
tartrolon a1 - Drug resistant
1,2,3-thiadiazole, 5-[(4-chlorophenyl)sulfonyl]-4-phenyl- - Drug sensitive
1h-1,4,7-triazonine-1,4,7-triacetic acid, octahydro- - Drug sensitive
1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive
2-azabicyclo[16.3.1]docosane, geldanamycin deriv. - Drug sensitive
3,3'-diamino-4,4'-bis(dimethylamino)benzophenone - Drug sensitive
4-quinazolone, 7-amino-3-(4-methoxyphenyl)-, hydrate - Drug sensitive
5-[2-(4-methoxyphenyl)ethyl]-1,2,3-dimethoxy benzene - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive
anthracen-9-one, 10-[(2-methoxyphenyl)methylene]- - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive
2-amino-5-chloro-6-(2-thiazolyloxy)-benzimidazole - Drug sensitive
antineoplastic-625577 - Drug sensitive
antineoplastic-d665837 - Drug sensitive
Artemisinin Dimer - Drug sensitive
chlorazin - Drug sensitive
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug sensitive
secafascaplysin - Drug sensitive
streptorubrin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-192-5p
Formaldehyde 712 Drug interaction    RC00001428
Oxaliplatine 6857599 Drug interaction    RC00001447
Gemcitabine 60750 Drug interaction    RC00001438
Sunitinib 5329102 Drug interaction    RC00001446
Eloxatine 5310940 Drug interaction    RC00001445
Docosahexaenoic acid 445580 Drug interaction    RC00001444
Paroxetine 43815 Drug interaction    RC00001437
Metformin 4091 Drug interaction    RC00001434
Bortezomib 387447 Drug interaction    RC00001443
Paclitaxel 36314 Drug interaction    RC00001436
5-Fluorouracil 3385 Drug interaction    RC00001433
Doxorubicin 31703 Drug interaction    RC00001435
Diphenylpyraline 3103 Drug interaction    RC00001432
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001431
Verapamil 2520 Drug interaction    RC00001430
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001448
Sorafenib 216239 Drug interaction    RC00001442
Acetaminophen 1983 Drug interaction    RC00001429
Docetaxel 148124 Drug interaction    RC00001441
Leucovorin 135403648 Drug interaction    RC00001449
Methotrexate 126941 Drug interaction    RC00001440
5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001450
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-192-5p
5-Fluorouracil 3385       25356050
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-192-5p
Interactor2: ZMAT3

Evidence Support:


Weak-Evidence Small RNA sequencing
Prediction-Evidence miRNet
Support Database ViRBase

References:


PMID 33045840 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line PBMC cells Interactor2 expression Upregulation
Description FIG. 2.(A) Downregulated miRNAs with their predicted upregulated gene targets.

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