Basic Information:

  VIRBase ID:  

HHID00095232

  Virus:  

Rotavirus

  Host:  

Sus scrofa

  Confidence Score:  

0.9639

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-155-5p:  MIMAT0000165          TBK1:  NM_001105292     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-155-5p	TBK1
miRBase Accession/Entrez ID	MIMAT0000165	100125828
Organism	Sus scrofa	Sus scrofa
Category	miRNA	mRNA
Alias	-	-

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-155-5p	Exosome Mouse metastatic mammary carcinoma cells (4T1)|Non-tumorigenic mouse mammary epithelial cells (NMuMG)     25446899 Exosome Bone marrow-derived dendritic cells     26084661 Exosome Serum     28160157 Exosome B6 BMDCs     22031862 Exosome Mouse hypothalamic neuronal cell line (GT1-7)     22965126 Exosome Bone marrow-derived macrophages     25159140 Mitochondrion Hippocampus neuron|Liver tissue     27396686 Mitochondrion Liver tissue     20733615 Nucleus Cortex neurons|Hippocampus neurons     28804446

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-155-5p
Interactor2: TBK1

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence	miRanda//PicTar//Targetscan
Support Database	ViRBase

References:

PMID	31330869	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	HeLa cells//IPEC-J2 cells	Interactor2 expression	Downregulation
Description	Overexpression of miR-155-5p remarkably suppressed the mRNA expression levels of TBK1, IRF3, and IFN-beta (p < 0.01), while the inhibition of miR-155-5p enhanced the expressions of these genes (p < 0.01) compared to our control group.