Detail Information

Basic Information:


  VIRBase ID:  

HHID00095185

  Virus:  

Orf virus

  Host:  

Capra hircus

  Confidence Score:  

0.9103

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol cfa-let-7a_R+2 TIMM17B
miRBase
Accession/Entrez ID		 cfa-let-7a_R+2 102173542
Organism Capra hircus Capra hircus
Category miRNA mRNA
Alias - -

Interaction Network (The top 100 interactions):


Interactor1: cfa-let-7a_R+2
Interactor2: TIMM17B

Evidence Support:


Strong-Evidence qRT-PCR
Weak-Evidence MiRNA sequencing//RNA-Seq
Prediction-Evidence miRanda//Targetscan
Support Database ViRBase

References:


PMID 31963559 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line GSF cells Interactor2 expression Downregulation
Description Results indicate that cfa-let-7a_R+2 mimic significantly reduced the mRNA expression level of beta-1,3-glucuronyltransferase 3 (B3GAT3), ring finger protein 7 (RNF7), transforming growth factor beta receptor 3 (TGFBR3), thrombospondin 1 (THBS1), and translocase of inner mitochondrial membrane 17B (TIMM17B) (Figure 9A). Significant downregulation of RNF7, TGFBR3, THBS1, and TIMM17B was verified by RT-qPCR (Figure 9B).

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