Basic Information:
VIRBase ID:
HHID00095175
Virus:
Orf virus
Host:
Capra hircus
Confidence Score:
0.9842
Interaction Type:
Host-Host interaction
Interactor Information:
|
Interactor1 |
Interactor2 |
| Symbol |
cfa-let-7a_R+2 |
THBS1 |
miRBase
Accession/Entrez ID |
cfa-let-7a_R+2 |
100860971 |
| Organism |
Capra hircus |
Capra hircus |
| Category |
miRNA |
mRNA |
| Alias |
-
|
-
|
Interaction Network (The top 100 interactions):
| Interactor1: cfa-let-7a_R+2 |
|
Interactor2: THBS1 |
|
Evidence Support:
| Strong-Evidence |
Dual luciferase reporter assay//qRT-PCR//Western blot |
| Weak-Evidence |
MiRNA sequencing//RNA-Seq |
| Prediction-Evidence |
miRanda//Targetscan |
| Support Database |
ViRBase
|
References:
| PMID |
31963559 |
Target region |
3'UTR |
| Source |
ViRBase
|
Interactor1 expression |
Upregulation |
| Tissue or cell line |
293T cells//GSF cells |
Interactor2 expression |
Downregulation |
| Description |
Based on these findings, we postulate that cfa-let-7a_R+2 directly targets THBS1 3'UTR to suppress expression of THBS1 mRNA and protein. |
