Basic Information:

  VIRBase ID:  

HHID00093502

  Virus:  

Enterovirus A71 (EV-A71)

  Host:  

Homo sapiens

  Confidence Score:  

0.9639

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548n:  MIMAT0005916          IFNL1:  NM_172140     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548n	IFNL1
miRBase Accession/Entrez ID	MIMAT0005916	282618
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IL-29//IL29

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548n	rs1167799411 chr7:34940804    A/G rs1349024540 chr7:34940825    G/C rs1440338026 chr7:34940814    C/G rs1440338026 chr7:34940814    C/T rs1014154255 chr7:34940819    A/G rs1170899735 chr7:34940820    C/T rs541369935 chr7:34940820    CT/C

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548n	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	IFNL1	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548n
Interactor2: IFNL1

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence	miRanda//PicTar//Targetscan
Support Database	ViRBase

References:

PMID	23150165	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	HepG2 cells//RD cells	Interactor2 expression	None
Description	After analysis with microRNA (miRNA) prediction programs and 3'UTR targeting site assays, the miRNA-548 family, including miR-548b-5p, miR-548c-5p, miR-548i, miR-548j, and miR-548n, was identified to target the 3'UTR of IFN-Lambda1. Further study demonstrated that miRNA-548 mimics down-regulated the expression of IFN-Lambda1.