Detail

Basic Information:

VIRBase ID:

HHID00093501

Virus:

Enterovirus A71 (EV-A71)

Host:

Homo sapiens

Confidence Score:

0.9639

Interaction Type:

Host-Host interaction

Predicted Binding:

*It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548j-5p	IFNL1
miRBase Accession/Entrez ID	MIMAT0005875	282618
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IL-29//IL29

ncRNA SNP information:

Resource

Symbol

SNP ID

SNP Position

Ref/Alt

miRNASNP-v3

hsa-miR-548j-5p

rs1210209539	chr22:26555275	C/T
rs545900525	chr22:26555280	G/C
rs565141718	chr22:26555283	C/A
rs565141718	chr22:26555283	C/G
rs565141718	chr22:26555283	C/T
rs751780445	chr22:26555284	G/A
rs753744163	chr22:26555282	C/A
rs757533254	chr22:26555285	C/A
rs367750295	chr22:26555290	A/G
rs976434292	chr22:26555292	T/C

RNA Localization:

Resource

Symbol

Subcellular Localization

Tissue or Cell Line

PMID

RNALocate

hsa-miR-548j-5p

Exosome	Breast milk\|Cell lines\|Epididymal epithelial cells\|Osteoblast\|Plasma\|Primary glioblastoma neurosphere cells\|Primary keratinocyte\|Saliva\|Serum\|Urine	-
Microvesicle	Fibroblasts\|Mesenchymal stem cells	-

IFNL1

Exosome

Blood

-

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548j-5p

Interactor2: IFNL1

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence	miRanda//PicTar//Targetscan
Support Database	ViRBase

References:

PMID	23150165	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	HepG2 cells//RD cells	Interactor2 expression	None
Description	After analysis with microRNA (miRNA) prediction programs and 3'UTR targeting site assays, the miRNA-548 family, including miR-548b-5p, miR-548c-5p, miR-548i, miR-548j, and miR-548n, was identified to target the 3'UTR of IFN-Lambda1. Further study demonstrated that miRNA-548 mimics down-regulated the expression of IFN-Lambda1.