Basic Information:
VIRBase ID: HHID00093499
Virus: Enterovirus A71 (EV-A71)
Host: Homo sapiens
Confidence Score: 0.9639
Interaction Type: Host-Host interaction
Predicted Binding:
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ncRNA SNP information:
Resource
Symbol
SNP ID
SNP Position
Ref/Alt
miRNASNP-v3
hsa-miR-548c-5p
RNA Localization:
Resource
Symbol
Subcellular Localization
Tissue or Cell Line
PMID
RNALocate
hsa-miR-548c-5p
IFNL1
Related Drug Information:
Resource
Symbol
Drug Name
PubChem ID
Function
Link
RNAInter
hsa-miR-548c-5p
Resource
Symbol
Drug Name
PubChem ID
RNAactDrug
hsa-miR-548c-5p
Interaction Network (The top 100 interactions) :
Interactor1: hsa-miR-548c-5p
Interactor2: IFNL1
Evidence Support:
Strong-Evidence
Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence
miRanda//PicTar//Targetscan
Support Database
ViRBase
References:
PMID
23150165
Target region
3'UTR
Source
ViRBase
Interactor1 expression
Downregulation
Tissue or cell line
HepG2 cells//RD cells
Interactor2 expression
None
Description
After analysis with microRNA (miRNA) prediction programs and 3'UTR targeting site assays, the miRNA-548 family, including miR-548b-5p, miR-548c-5p, miR-548i, miR-548j, and miR-548n, was identified to target the 3'UTR of IFN-Lambda1. Further study demonstrated that miRNA-548 mimics down-regulated the expression of IFN-Lambda1.