Basic Information:

  VIRBase ID:  

HHID00093488

  Virus:  

Coxsackievirus B3 (CVB3)

  Host:  

Mus musculus

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      Predicted binding sites in PRIdictor:   Pdcd4:  NP_001161964     

Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-21a-3p	Pdcd4
miRBase Accession/Entrez ID	MIMAT0004628	18569
Organism	Mus musculus	Mus musculus
Category	miRNA	protein
Alias	-	D19Ucl//D19Ucla1//MA-//Ma3//T//Tis

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Pdcd4	chr19:53903363-53903364(+) m6A 5'UTR//intron       25456834//25412662//24981863//25569111 chr19:53903368-53903369(+) m6A 5'UTR//intron       25456834//25412662//24981863//25569111 chr19:53903374-53903375(+) m6A 5'UTR//intron       25456834//25412662//24981863//25569111 chr19:53903452-53903453(+) m6A 5'UTR//intron       25412662//24981863//25456834//25569111 chr19:53903459-53903460(+) m6A 5'UTR//intron       25412662//24981863//25456834//25569111 chr19:53907461-53907462(+) m6A 5'UTR       24981863//25456834//25569111 chr19:53907533-53907534(+) m6A CDS       24981863//25569111 chr19:53907546-53907547(+) m6A CDS       24981863//25569111 chr19:53909276-53909277(+) m6A CDS       25683224//25412662//24981863//25569111 chr19:53909291-53909292(+) m6A CDS       25683224//25412662//24981863//25569111 chr19:53910964-53910965(+) m6A CDS       24981863 chr19:53911005-53911006(+) m6A CDS       24981863 chr19:53912815-53912816(+) m6A CDS       24981863 chr19:53912829-53912830(+) m6A CDS       24981863 chr19:53912853-53912854(+) m6A CDS       24981863//22608085 chr19:53919816-53919817(+) m6A CDS       25412662//22608085//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-21a-3p	Nucleus Liver cells     21862971
	Pdcd4	Nucleus Neuroblastoma cell line (N2A)     22406755

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-21a-3p
Interactor2: Pdcd4

Evidence Support:

Strong-Evidence	IHC//RT-PCR
Support Database	ViRBase

References:

PMID	23544605	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	Cardiovascular cells	Interactor2 expression	Upregulation
Description	Further study showed that miR-21 could protect myocardial apoptosis by specifically inhibiting its target programmed cell death 4(PDCD4) expression.Myocardial microRNA expression changes in CVB3-infected mice were analyzed by real-time PCR and miR-21 was found to be the miRNA whose expression was significantly reduced. miR-21 administration efficiently alleviated CVB3-induced myocarditis by repressing PDCD4-mediated apoptosis.