Detail Information

Basic Information:


  VIRBase ID:  

HHID00093482

  Virus:  

Severe fever with thrombocytopenia syndrome virus (SFTSV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-146b-3p:           IL10:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-146b-3p IL10
miRBase
Accession/Entrez ID		 MIMAT0004766 3586
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CSIF//GVHDS//IL-10//IL10A//TGIF

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-146b-3p
rs1367942461 chr10:102436557    G/A
rs1467375133 chr10:102436569    C/A
rs766852690 chr10:102436575    TGGTGCCC/T
rs768018523 chr10:102436577    G/C
rs1425832655 chr10:102436558    C/T
rs944616447 chr10:102436564    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IL10
chr1:206941331(-) A-I      3'UTR

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-146b-3p
Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698
Exosome Plasma     23663360
Exosome Mast cells     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
IL10
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-146b-3p
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-146b-3p
Interactor2: IL10

Evidence Support:


Strong-Evidence ELISA//qPCR
Support Database ViRBase

References:


PMID 31156641 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line THP1 cells Interactor2 expression Upregulation
Description Together, these data indicate that miR-146a and b play distinct roles in regulating SFTSV-induced macrophage differentiation and identify miR-146b, but not miR-146a, as an IL-10-induced miRNA.

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