Basic Information:

  VIRBase ID:  

HHID00093429

  Virus:  

Oropouche virus

  Host:  

Homo sapiens

  Confidence Score:  

0.6061

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-217-3p:  MIMAT0037308          TM9SF3:  NM_020123     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-217-3p	TM9SF3
miRBase Accession/Entrez ID	MIMAT0037308	56889
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	EP70-P-iso//SMBP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-217-3p	rs1187223790 chr2:55982995    A/G rs1252320359 chr2:55982988    A/G rs1252320359 chr2:55982988    A/T rs1276986732 chr2:55982986    C/T rs41291173 chr2:55983005    G/A rs41291173 chr2:55983005    G/C rs1291461563 chr2:55983001    T/C rs374669006 chr2:55983004    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TM9SF3	chr10:98300788(-) A-I      intronic chr10:98300785(-) A-I      intronic chr10:98300794(-) A-I      intronic chr10:98300793(-) A-I      intronic chr10:98329677(-) A-I      intronic chr10:98323987(-) A-I      intronic chr10:98340218(-) A-I      intronic chr10:98330623(-) A-I      intronic chr10:98322887(-) A-I      intronic chr10:98322956(-) A-I      intronic chr10:98340083(-) A-I      intronic chr10:98330768(-) A-I      intronic chr10:98340207(-) A-I      intronic chr10:98338622(-) A-I      intronic chr10:98338665(-) A-I      intronic chr10:98338671(-) A-I      intronic chr10:98323927(-) A-I      intronic chr10:98344403(-) A-I      intronic chr10:98322961(-) A-I      intronic chr10:98330751(-) A-I      intronic chr10:98340204(-) A-I      intronic chr10:98338715(-) A-I      intronic chr10:98323981(-) A-I      intronic chr10:98296651(-) A-I      intronic chr10:98300777(-) A-I      intronic chr10:98340290(-) A-I      intronic chr10:98340194(-) A-I      intronic chr10:98338751(-) A-I      intronic chr10:98340228(-) A-I      intronic chr10:98340226(-) A-I      intronic chr10:98323997(-) A-I      intronic chr10:98338788(-) A-I      intronic chr10:98338661(-) A-I      intronic chr10:98297494(-) A-I      intronic chr10:98340161(-) A-I      intronic chr10:98328826(-) A-I      intronic chr10:98329689(-) A-I      intronic chr10:98338676(-) A-I      intronic chr10:98330635(-) A-I      intronic chr10:98338777(-) A-I      intronic chr10:98338722(-) A-I      intronic chr10:98329626(-) A-I      intronic chr10:98340056(-) A-I      intronic chr10:98297506(-) A-I      intronic chr10:98338667(-) A-I      intronic chr10:98297473(-) A-I      intronic chr10:98329546(-) A-I      intronic chr10:98332390(-) A-I      intronic chr10:98323937(-) A-I      intronic chr10:98338653(-) A-I      intronic chr10:98323271(-) A-I      intronic chr10:98340187(-) A-I      intronic chr10:98322971(-) A-I      intronic chr10:98299011(-) A-I      intronic chr10:98298985(-) A-I      intronic chr10:98328845(-) A-I      intronic chr10:98342664(-) A-I      intronic chr10:98340287(-) A-I      intronic chr10:98344409(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TM9SF3	chr10:98320668(-) A-I intron -    22327324 chr10:98296691(-) A-I intron -    21960545 chr10:98296716(-) A-I intron -    21960545 chr10:98322971(-) A-I intron -    21960545 chr10:98323937(-) A-I intron -    21960545 chr10:98323997(-) A-I intron -    21960545 chr10:98338621(-) A-I intron -    21960545 chr10:98338712(-) A-I intron -    21960545 chr10:98338722(-) A-I intron -    21960545 chr10:98338777(-) A-I intron -    21960545 chr10:98322971(-) A-G intron -    22484847 chr10:98340161(-) A-G intron -    22484847 chr10:98343775(-) C-T intron -    22484847 chr10:98281484(-) T-C exon 3'UTR    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TM9SF3	chr10:98278050-98278051(-) m6A 3'UTR       24981863//22608085 chr10:98278075-98278076(-) m6A 3'UTR       24981863//22608085 chr10:98278106-98278107(-) m6A 3'UTR       24981863//22608085 chr10:98278149-98278150(-) m6A 3'UTR       22608085 chr10:98278157-98278158(-) m6A 3'UTR       22608085 chr10:98280601-98280602(-) m6A 3'UTR       - chr10:98280623-98280624(-) m6A 3'UTR       - chr10:98280646-98280647(-) m6A 3'UTR       - chr10:98281033-98281034(-) Cm 3'UTR       - chr10:98281112-98281113(-) m6A 3'UTR       26404942 chr10:98281319-98281320(-) m6A 3'UTR       26404942 chr10:98281367-98281368(-) m6A 3'UTR       26404942 chr10:98281394-98281395(-) m6A 3'UTR       26404942 chr10:98281529-98281530(-) m6A 3'UTR       26404942 chr10:98281659-98281660(-) m6A 3'UTR       26404942 chr10:98281708-98281709(-) m6A 3'UTR       24284625//26404942 chr10:98281731-98281732(-) m6A 3'UTR       24284625//22608085 chr10:98281755-98281756(-) m6A 3'UTR       24284625//22608085 chr10:98281951-98281952(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr10:98281966-98281967(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr10:98281999-98282000(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr10:98282006-98282007(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr10:98282016-98282017(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr10:98282066-98282067(-) m6A CDS//exon       24284625//24981863//26404942//27371828//22608085 chr10:98321836-98321837(-) m6A CDS//exon       26404942 chr10:98321847-98321848(-) m6A CDS//exon       26404942 chr10:98336381-98336382(-) m6A exon//intron       26404942 chr10:98336453-98336454(-) m6A CDS//exon       26404942//27773535 chr10:98336519-98336520(-) m6A CDS//exon       24209618//26404942//27773535 chr10:98337276-98337277(-) m6A exon//intron       24209618 chr10:98346496-98346497(-) m6A CDS//exon//intron       24209618//27371828//27773536 chr10:98346516-98346517(-) m6A CDS//intron       24209618//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-217-3p	Cytoplasm Cell lines (Aspc-1Panc-1)     28701723 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Nucleus Cell lines (Aspc-1Panc-1)     28701723
	TM9SF3	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-217-3p
Interactor2: TM9SF3

Evidence Support:

Weak-Evidence	miRNA array
Prediction-Evidence	miRanda//miRBase//miRTarget2//PicTar//TarBase//Targetscan
Support Database	ViRBase

References:

PMID	29813068	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Huh-7 cells	Interactor2 expression	None
Description	Target genes predicted by at least 3 out of 6 of those databases were considered candidates. We predicted 195 cellular genes to interact with miR-217, miR-576-3p, or both, using that criterion (S2 Table).