Detail Information

Basic Information:


  VIRBase ID:  

HHID00093315

  Virus:  

Oropouche virus

  Host:  

Homo sapiens

  Confidence Score:  

0.6061

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-576-3p:           RGPD6:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-576-3p RGPD6
miRBase
Accession/Entrez ID		 MIMAT0004796 729540
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - RanBP2L1//RanBP2L2//RGP6//RGPD7

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-576-3p
rs1186952823 chr4:109488766    T/C
rs1472315985 chr4:109488773    C/T
rs71603032 chr4:109488767    T/G
rs910619778 chr4:109488769    G/A
rs1286950821 chr4:109488755    A/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RGPD6
chr2:110572683(+) A-I      intronic
chr2:110572738(+) A-I      intronic
chr2:110572693(+) A-I      intronic
chr2:110573558(+) A-I      intronic
chr2:110573370(+) A-I      intronic
chr2:110556802(+) A-I      intronic
chr2:111329852(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RGPD6
chr2:111271906-111271907(-) Y 3'UTR//exon       26075521

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-576-3p
Exosome Plasma     23663360
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
RGPD6
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-576-3p
D-Glucose 5793 Drug interaction    RC00007190
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-576-3p
Cisplatin 5702198       21575166
Doxorubicin 31703       25451164

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-576-3p
Interactor2: RGPD6

Evidence Support:


Weak-Evidence miRNA array
Prediction-Evidence miRanda//miRBase//miRTarget2//PicTar//TarBase//Targetscan
Support Database ViRBase

References:


PMID 29813068 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line Huh-7 cells Interactor2 expression None
Description We selected 95 target genes, which were either in the group of 195 predicted target genes (92 genes) and/or either were already published as target genes for those miRNAs, to evaluate their expression through RT-PCR in OROV infected hepatocyte cells.

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