Basic Information:

  VIRBase ID:  

HHID00093298

  Virus:  

Oropouche virus

  Host:  

Homo sapiens

  Confidence Score:  

0.6061

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-576-3p:  MIMAT0004796          ARHGAP15:  NM_018460     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-576-3p	ARHGAP15
miRBase Accession/Entrez ID	MIMAT0004796	55843
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BM046

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-576-3p	rs1186952823 chr4:109488766    T/C rs1472315985 chr4:109488773    C/T rs71603032 chr4:109488767    T/G rs910619778 chr4:109488769    G/A rs1286950821 chr4:109488755    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ARHGAP15	chr2:144249551(+) A-I      intronic chr2:144073576(+) A-I      intronic chr2:144151140(+) A-I      intronic chr2:144151145(+) A-I      intronic chr2:143976912(+) A-I      intronic chr2:144362534(+) A-I      intronic chr2:144362536(+) A-I      intronic chr2:144363501(+) A-I      intronic chr2:143976837(+) A-I      intronic chr2:143976328(+) A-I      intronic chr2:143854810(+) A-I      intronic chr2:144363511(+) A-I      intronic chr2:144493842(+) A-I      intronic chr2:143976317(+) A-I      intronic chr2:144151111(+) A-I      intronic chr2:143976310(+) A-I      intronic chr2:143976283(+) A-I      intronic chr2:143976299(+) A-I      intronic chr2:143976349(+) A-I      intronic chr2:143854804(+) A-I      intronic chr2:144151136(+) A-I      intronic chr2:143854789(+) A-I      intronic chr2:143854795(+) A-I      intronic chr2:143854798(+) A-I      intronic chr2:144096207(+) A-I      intronic chr2:144095102(+) A-I      intronic chr2:143976333(+) A-I      intronic chr2:143854834(+) A-I      intronic chr2:143854843(+) A-I      intronic chr2:143854854(+) A-I      intronic chr2:143854855(+) A-I      intronic chr2:144029975(+) A-I      intronic chr2:144087495(+) A-I      intronic chr2:144087514(+) A-I      intronic chr2:144087519(+) A-I      intronic chr2:144087540(+) A-I      intronic chr2:144087554(+) A-I      intronic chr2:144087557(+) A-I      intronic chr2:144087564(+) A-I      intronic chr2:144151096(+) A-I      intronic chr2:144151139(+) A-I      intronic chr2:144151099(+) A-I      intronic chr2:144151100(+) A-I      intronic chr2:144151105(+) A-I      intronic chr2:144363592(+) A-I      intronic chr2:144363484(+) A-I      intronic chr2:144362621(+) A-I      intronic chr2:143937208(+) A-I      intronic chr2:143937210(+) A-I      intronic chr2:143980795(+) A-I      intronic chr2:143980805(+) A-I      intronic chr2:144029095(+) A-I      intronic chr2:144514848(+) A-I      intronic chr2:144495547(+) A-I      intronic chr2:144495536(+) A-I      intronic chr2:144030174(+) A-I      intronic chr2:144493854(+) A-I      intronic chr2:144493871(+) A-I      intronic chr2:144493827(+) A-I      intronic chr2:144479445(+) A-I      intronic chr2:144478556(+) A-I      intronic chr2:144478517(+) A-I      intronic chr2:144478495(+) A-I      intronic chr2:144029945(+) A-I      intronic chr2:144093601(+) A-I      intronic chr2:144029174(+) A-I      intronic chr2:144029234(+) A-I      intronic chr2:144029306(+) A-I      intronic chr2:144029307(+) A-I      intronic chr2:144093663(+) A-I      intronic chr2:144093669(+) A-I      intronic chr2:144110785(+) A-I      intronic chr2:144122436(+) A-I      intronic chr2:144130991(+) A-I      intronic chr2:144131084(+) A-I      intronic chr2:144132129(+) A-I      intronic chr2:144132189(+) A-I      intronic chr2:144132197(+) A-I      intronic chr2:144132213(+) A-I      intronic chr2:144132229(+) A-I      intronic chr2:144132292(+) A-I      intronic chr2:144248221(+) A-I      intronic chr2:144249531(+) A-I      intronic chr2:144249651(+) A-I      intronic chr2:144250220(+) A-I      intronic chr2:144250224(+) A-I      intronic chr2:144259750(+) A-I      intronic chr2:144259816(+) A-I      intronic chr2:144259817(+) A-I      intronic chr2:144259935(+) A-I      intronic chr2:144259963(+) A-I      intronic chr2:144259966(+) A-I      intronic chr2:144493876(+) A-I      intronic chr2:144029109(+) A-I      intronic chr2:144362588(+) A-I      intronic chr2:144362564(+) A-I      intronic chr2:144362558(+) A-I      intronic chr2:144362509(+) A-I      intronic chr2:144362503(+) A-I      intronic chr2:144356357(+) A-I      intronic chr2:144319259(+) A-I      intronic chr2:144319253(+) A-I      intronic chr2:144260384(+) A-I      intronic chr2:144260253(+) A-I      intronic chr2:144260252(+) A-I      intronic chr2:144260210(+) A-I      intronic chr2:144260179(+) A-I      intronic chr2:144478491(+) A-I      intronic chr2:144478484(+) A-I      intronic chr2:144431076(+) A-I      intronic chr2:144431047(+) A-I      intronic chr2:144431039(+) A-I      intronic chr2:144425289(+) A-I      intronic chr2:144392796(+) A-I      intronic chr2:144363396(+) A-I      intronic chr2:144363468(+) A-I      intronic chr2:144362661(+) A-I      intronic chr2:144132227(+) A-I      intronic chr2:143937405(+) A-I      intronic chr2:144029184(+) A-I      intronic chr2:144030004(+) A-I      intronic chr2:144362577(+) A-I      intronic chr2:144029319(+) A-I      intronic chr2:144260332(+) A-I      intronic chr2:144392857(+) A-I      intronic chr2:144132201(+) A-I      intronic chr2:144029922(+) A-I      intronic chr2:144363490(+) A-I      intronic chr2:144029088(+) A-I      intronic chr2:144030107(+) A-I      intronic chr2:144363397(+) A-I      intronic chr2:144030101(+) A-I      intronic chr2:144029261(+) A-I      intronic chr2:144493766(+) A-I      intronic chr2:144260349(+) A-I      intronic chr2:144363537(+) A-I      intronic chr2:144132211(+) A-I      intronic chr2:144132138(+) A-I      intronic chr2:144130944(+) A-I      intronic chr2:144029944(+) A-I      intronic chr2:144362617(+) A-I      intronic chr2:144029119(+) A-I      intronic chr2:144260358(+) A-I      intronic chr2:144363525(+) A-I      intronic chr2:144356405(+) A-I      intronic chr2:144030102(+) A-I      intronic chr2:144130945(+) A-I      intronic chr2:144362611(+) A-I      intronic chr2:144034246(+) A-I      intronic chr2:144249482(+) A-I      intronic chr2:143983115(+) A-I      intronic chr2:143980817(+) A-I      intronic chr2:144363494(+) A-I      intronic chr2:144478383(+) A-I      intronic chr2:144363421(+) A-I      intronic chr2:144259831(+) A-I      intronic chr2:143980725(+) A-I      intronic chr2:144260249(+) A-I      intronic chr2:143936263(+) A-I      intronic chr2:143937340(+) A-I      intronic chr2:144425352(+) A-I      intronic chr2:144362578(+) A-I      intronic chr2:144478384(+) A-I      intronic chr2:144030173(+) A-I      intronic chr2:144248300(+) A-I      intronic chr2:144430898(+) A-I      intronic chr2:144362658(+) A-I      intronic chr2:144132097(+) A-I      intronic chr2:144363526(+) A-I      intronic chr2:144168672(+) A-I      intronic chr2:144029252(+) A-I      intronic chr2:144430970(+) A-I      intronic chr2:143937228(+) A-I      intronic chr2:144030133(+) A-I      intronic chr2:144029928(+) A-I      intronic chr2:144249590(+) A-I      intronic chr2:144029953(+) A-I      intronic chr2:144363422(+) A-I      intronic chr2:144495430(+) A-I      intronic chr2:144362595(+) A-I      intronic chr2:144363319(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ARHGAP15	chr2:144130944(+) A-I intron -    22327324 chr2:144130945(+) A-I intron -    22327324 chr2:144131078(+) A-I intron -    22327324 chr2:144132211(+) A-I intron -    22327324 chr2:144362611(+) A-I intron -    22327324 chr2:143937175(+) A-G intron -    22484847 chr2:143936263(+) A-G intron -    22484847 chr2:143972848(+) C-T intron -    22484847 chr2:144019068(+) C-T intron -    22484847 chr2:144027783(+) A-C intron -    22484847 chr2:144029088(+) A-G intron -    22484847 chr2:144029119(+) A-G intron -    22484847 chr2:144029184(+) A-G intron -    22484847 chr2:144029252(+) A-G intron -    22484847 chr2:144029261(+) A-G intron -    22484847 chr2:144029922(+) A-G intron -    22484847 chr2:144029928(+) A-G intron -    22484847 chr2:144029944(+) A-G intron -    22484847 chr2:144029953(+) A-G intron -    22484847 chr2:144030004(+) A-G intron -    22484847 chr2:144030012(+) A-G intron -    22484847 chr2:144030013(+) A-G intron -    22484847 chr2:144030101(+) A-G intron -    22484847 chr2:144030107(+) A-G intron -    22484847 chr2:144030147(+) A-G intron -    22484847 chr2:144030173(+) A-G intron -    22484847 chr2:144034246(+) A-G intron -    22484847 chr2:144045264(+) C-T intron -    22484847 chr2:144248300(+) A-G intron -    22484847 chr2:144249482(+) A-G intron -    22484847 chr2:144249547(+) T-C intron -    22484847 chr2:144249590(+) A-G intron -    22484847 chr2:144249719(+) A-G intron -    22484847 chr2:144259831(+) A-G intron -    22484847 chr2:144259847(+) A-G intron -    22484847 chr2:144259858(+) A-G intron -    22484847 chr2:144260248(+) A-G intron -    22484847 chr2:144260332(+) A-G intron -    22484847 chr2:144260349(+) A-G intron -    22484847 chr2:144260358(+) A-G intron -    22484847 chr2:144362499(+) A-G intron -    22484847 chr2:144362577(+) A-G intron -    22484847 chr2:144362578(+) A-G intron -    22484847 chr2:144362611(+) A-G intron -    22484847 chr2:144362617(+) A-G intron -    22484847 chr2:144362619(+) A-G intron -    22484847 chr2:144362658(+) A-G intron -    22484847 chr2:144362661(+) A-G intron -    22484847 chr2:144362721(+) A-G intron -    22484847 chr2:144430898(+) A-G intron -    22484847 chr2:144430970(+) A-G intron -    22484847 chr2:144478383(+) A-G intron -    22484847 chr2:144495426(+) A-G intron -    22484847 chr2:144495430(+) A-G intron -    22484847 chr2:144058653(+) A-G intron -    22484847 chr2:144095105(+) A-G intron -    22484847 chr2:144096130(+) A-G intron -    22484847 chr2:144096134(+) A-G intron -    22484847 chr2:144096181(+) A-G intron -    22484847

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-576-3p	Exosome Plasma     23663360 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	ARHGAP15	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-576-3p	D-Glucose 5793 Drug interaction    RC00007190

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-576-3p	Cisplatin 5702198       21575166 Doxorubicin 31703       25451164

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-576-3p
Interactor2: ARHGAP15

Evidence Support:

Weak-Evidence	miRNA array
Prediction-Evidence	miRanda//miRBase//miRTarget2//PicTar//TarBase//Targetscan
Support Database	ViRBase

References:

PMID	29813068	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Huh-7 cells	Interactor2 expression	None
Description	Target genes predicted by at least 3 out of 6 of those databases were considered candidates. We predicted 195 cellular genes to interact with miR-217, miR-576-3p, or both, using that criterion (S2 Table).