Detail Information

Basic Information:


  VIRBase ID:  

HHID00093202

  Virus:  

Oropouche virus

  Host:  

Homo sapiens

  Confidence Score:  

0.6061

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-217-5p:           CILK1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-217-5p CILK1
miRBase
Accession/Entrez ID		 MIMAT0000274 22858
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ECO//EJM10//hICK//ICK//LCK2//MRK

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-217-5p
rs1177184290 chr2:55983042    A/G
rs1183317793 chr2:55983028    G/T
rs140509279 chr2:55983033    T/C
rs371400782 chr2:55983020    T/C
rs751993696 chr2:55983026    C/T
rs757538047 chr2:55983029    T/A
rs757538047 chr2:55983029    T/C
rs778023376 chr2:55983024    A/G
rs1463993894 chr2:55983036    T/A
rs963627102 chr2:55983041    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CILK1
chr6:52892577(-) A-I      intronic
chr6:52914791(-) A-I      intronic
chr6:52892573(-) A-I      intronic
chr6:52886001(-) A-I      intronic
chr6:52914785(-) A-I      intronic
chr6:52892611(-) A-I      intronic
chr6:52892585(-) A-I      intronic
chr6:52886041(-) A-I      intronic
chr6:52886037(-) A-I      intronic
chr6:52886036(-) A-I      intronic
chr6:52886028(-) A-I      intronic
chr6:52872694(-) A-I      intronic
chr6:52914731(-) A-I      intronic
chr6:52868290(-) A-I      3'UTR
chr6:52868293(-) A-I      3'UTR
chr6:52868316(-) A-I      3'UTR
chr6:52868348(-) A-I      3'UTR
chr6:52868294(-) A-I      3'UTR
chr6:52873399(-) A-I      intronic
chr6:52873502(-) A-I      intronic
chr6:52889898(-) A-I      intronic
chr6:52868457(-) A-I      3'UTR
chr6:52896881(-) A-I      intronic
chr6:52873361(-) A-I      intronic
chr6:52873406(-) A-I      intronic
chr6:52873470(-) A-I      intronic
chr6:52914792(-) A-I      intronic
chr6:52872655(-) A-I      intronic
chr6:52887860(-) A-I      intronic
chr6:52885862(-) A-I      intronic
chr6:52893038(-) A-I      intronic
chr6:52873525(-) A-I      intronic

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-217-5p
Cytoplasm Cell lines (Aspc-1Panc-1)     28701723
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
Nucleus Cell lines (Aspc-1Panc-1)     28701723
CILK1
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-217-5p
Interactor2: CILK1

Evidence Support:


Weak-Evidence miRNA array
Prediction-Evidence miRanda//miRBase//miRTarget2//PicTar//TarBase//Targetscan
Support Database ViRBase

References:


PMID 29813068 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Huh-7 cells Interactor2 expression None
Description Target genes predicted by at least 3 out of 6 of those databases were considered candidates. We predicted 195 cellular genes to interact with miR-217, miR-576-3p, or both, using that criterion (S2 Table).

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