Detail Information

Basic Information:


  VIRBase ID:  

HHID00092989

  Virus:  

Human papillomavirus type 16 (HPV16)

  Host:  

Homo sapiens

  Confidence Score:  

0.9820

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-203b-3p:           TP53:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-203b-3p TP53
miRBase
Accession/Entrez ID		 MIMAT0019814 7157
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BCC7//BMFS5//LFS1//P53//TRP53

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-203b-3p
rs527418519 chr14:104117439    T/C
rs771545143 chr14:104117431    A/G
rs1307766631 chr14:104117443    C/G
rs1444131167 chr14:104117448    C/T

RNA Editing:


Resource Symbol Editing Position
Lncediting TP53
    chr17: 7588904
    chr17: 7588877
Resource Symbol Editing Position Change Genetic Region
RADAR TP53
chr17:7574250(-) A-I      intronic
chr17:7573520(-) A-I      intronic
chr17:7573351(-) A-I      intronic
chr17:7573387(-) A-I      intronic
chr17:7573391(-) A-I      intronic
chr17:7573398(-) A-I      intronic
chr17:7573399(-) A-I      intronic
chr17:7573478(-) A-I      intronic
chr17:7574292(-) A-I      intronic
chr17:7574227(-) A-I      intronic
chr17:7573369(-) A-I      intronic
chr17:7575291(-) A-I      intronic
chr17:7575306(-) A-I      intronic
chr17:7575453(-) A-I      intronic
chr17:7576230(-) A-I      intronic
chr17:7576261(-) A-I      intronic
chr17:7576264(-) A-I      intronic
chr17:7576361(-) A-I      intronic
chr17:7587661(-) A-I      intronic
chr17:7576380(-) A-I      intronic
chr17:7576396(-) A-I      intronic
chr17:7576405(-) A-I      intronic
chr17:7576421(-) A-I      intronic
chr17:7586541(-) A-I      intronic
chr17:7575466(-) A-I      intronic
chr17:7575516(-) A-I      intronic
chr17:7575536(-) A-I      intronic
chr17:7575592(-) A-I      intronic
chr17:7575608(-) A-I      intronic
chr17:7576437(-) A-I      intronic
chr17:7583952(-) A-I      intronic
chr17:7574403(-) A-I      intronic
chr17:7574462(-) A-I      intronic
chr17:7574463(-) A-I      intronic
chr17:7574479(-) A-I      intronic
chr17:7574730(-) A-I      intronic
chr17:7574756(-) A-I      intronic
chr17:7574767(-) A-I      intronic
chr17:7574782(-) A-I      intronic
chr17:7574800(-) A-I      intronic
chr17:7574811(-) A-I      intronic
chr17:7574821(-) A-I      intronic
chr17:7574826(-) A-I      intronic
chr17:7588904(-) A-I      intronic
chr17:7588877(-) A-I      intronic
chr17:7587669(-) A-I      intronic
chr17:7587624(-) A-I      intronic
chr17:7587598(-) A-I      intronic
chr17:7587574(-) A-I      intronic
chr17:7587205(-) A-I      intronic
chr17:7583956(-) A-I      intronic
chr17:7587199(-) A-I      intronic
chr17:7575775(-) A-I      intronic
chr17:7575868(-) A-I      intronic
chr17:7575939(-) A-I      intronic
chr17:7576110(-) A-I      intronic
chr17:7576184(-) A-I      intronic
chr17:7573279(-) A-I      intronic
chr17:7573315(-) A-I      intronic
chr17:7573355(-) A-I      intronic
chr17:7586686(-) A-I      intronic
chr17:7573435(-) A-I      intronic
chr17:7574228(-) A-I      intronic
chr17:7574305(-) A-I      intronic
chr17:7572048(-) A-I      3'UTR
chr17:7572107(-) A-I      3'UTR
chr17:7571943(-) A-I      3'UTR
chr17:7571926(-) A-I      3'UTR
chr17:7571944(-) A-I      3'UTR
chr17:7574393(-) A-I      intronic
chr17:7586338(-) A-I      intronic
chr17:7587302(-) A-I      intronic
chr17:7574688(-) A-I      intronic
chr17:7574296(-) A-I      intronic
chr17:7587561(-) A-I      intronic
chr17:7587082(-) A-I      intronic
chr17:7574520(-) A-I      intronic
chr17:7584245(-) A-I      intronic
chr17:7587693(-) A-I      intronic
chr17:7574572(-) A-I      intronic
chr17:7587621(-) A-I      intronic
chr17:7575299(-) A-I      intronic
chr17:7576319(-) A-I      intronic
chr17:7574311(-) A-I      intronic
chr17:7584291(-) A-I      intronic
chr17:7573395(-) A-I      intronic
chr17:7574545(-) A-I      intronic
chr17:7575897(-) A-I      intronic
chr17:7587676(-) A-I      intronic
chr17:7587514(-) A-I      intronic
chr17:7587473(-) A-I      intronic
chr17:7587534(-) A-I      intronic
chr17:7587218(-) A-I      intronic
chr17:7574298(-) A-I      intronic
chr17:7585684(-) A-I      intronic
chr17:7587701(-) A-I      intronic
chr17:7573459(-) A-I      intronic
chr17:7573390(-) A-I      intronic
chr17:7587545(-) A-I      intronic
chr17:7582810(-) A-I      intronic
chr17:7574715(-) A-I      intronic
chr17:7575858(-) A-I      intronic
chr17:7573473(-) A-I      intronic
chr17:7574318(-) A-I      intronic
chr17:7587126(-) A-I      intronic
chr17:7572004(-) A-I      3'UTR
chr17:7574265(-) A-I      intronic
chr17:7587660(-) A-I      intronic
chr17:7571913(-) A-I      3'UTR
chr17:7572141(-) A-I      3'UTR
chr17:7587472(-) A-I      intronic
chr17:7575233(-) A-I      intronic
chr17:7573467(-) A-I      intronic
chr17:7572026(-) A-I      3'UTR
chr17:7587671(-) A-I      intronic
chr17:7587663(-) A-I      intronic
chr17:7573334(-) A-I      intronic
chr17:7587200(-) A-I      intronic
chr17:7574341(-) A-I      intronic
chr17:7575528(-) A-I      intronic
chr17:7574913(-) A-I      intronic
chr17:7575356(-) A-I      intronic
chr17:7574407(-) A-I      intronic
chr17:7587537(-) A-I      intronic
chr17:7575244(-) A-I      intronic
chr17:7576064(-) A-I      intronic
chr17:7587301(-) A-I      intronic
chr17:7587668(-) A-I      intronic
chr17:7586352(-) A-I      intronic
chr17:7574783(-) A-I      intronic
chr17:7574517(-) A-I      intronic
chr17:7573472(-) A-I      intronic
chr17:7575465(-) A-I      intronic
chr17:7573360(-) A-I      intronic
chr17:7587190(-) A-I      intronic
chr17:7575947(-) A-I      intronic
chr17:7587198(-) A-I      intronic
chr17:7576006(-) A-I      intronic
chr17:7587499(-) A-I      intronic
chr17:7574757(-) A-I      intronic
chr17:7582804(-) A-I      intronic
chr17:7582053(-) A-I      intronic
chr17:7574539(-) A-I      intronic
chr17:7574258(-) A-I      intronic
chr17:7573454(-) A-I      intronic
chr17:7574354(-) A-I      intronic
chr17:7574328(-) A-I      intronic
chr17:7573361(-) A-I      intronic
chr17:7576027(-) A-I      intronic
chr17:7587525(-) A-I      intronic
chr17:7587645(-) A-I      intronic
chr17:7575777(-) A-I      intronic
chr17:7574547(-) A-I      intronic
chr17:7571931(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TP53
chr17:7587671(-) A-I intron -    22327324
chr17:7572004(-) A-G exon 3'UTR    22484847
chr17:7572148(-) C-T exon 3'UTR    22484847
chr17:7572154(-) C-T exon 3'UTR    22484847
chr17:7572173(-) C-T exon 3'UTR    22484847
chr17:7573360(-) A-G intron -    22484847
chr17:7573361(-) A-G intron -    22484847
chr17:7574354(-) A-G intron -    22484847
chr17:7574547(-) A-G intron -    22484847
chr17:7587198(-) A-G intron -    22484847
chr17:7587301(-) A-G intron -    22484847
chr17:7587302(-) A-G intron -    22484847
chr17:7587472(-) A-G intron -    22484847
chr17:7587645(-) A-G intron -    22484847
chr17:7587663(-) A-G intron -    22484847
chr17:7587668(-) A-G intron -    22484847
chr17:7587671(-) A-G intron -    22484847
chr17:7587676(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TP53
chr17:7569558-7569559(-) m6A CDS//intron       24981863//27773535
chr17:7571749-7571750(-) m6A 3'UTR//intron       24981863//27773535
chr17:7571942-7571943(-) m6A 3'UTR//intron       27773535
chr17:7572719-7572720(-) m6A 3'UTR//intron       26404942
chr17:7572771-7572772(-) m6A 3'UTR//intron       -
chr17:7572804-7572805(-) m6A 3'UTR//intron       -
chr17:7572843-7572844(-) m6A 3'UTR//intron       -
chr17:7572930-7572931(-) m6A 3'UTR//CDS//intron       27773535//27371828
chr17:7572949-7572950(-) m6A 3'UTR//CDS//intron       27773535//27371828
chr17:7572962-7572963(-) m6A 3'UTR//CDS//intron       27773535//27371828
chr17:7573979-7573980(-) m6A 3'UTR//CDS//intron       27371828
chr17:7576546-7576547(-) m6A 3'UTR//CDS//intron       27371828
chr17:7576650-7576651(-) m6A CDS//intron       24981863//27371828
chr17:7576882-7576883(-) m6A CDS//intron       24981863//27371828//27773536
chr17:7577095-7577096(-) m6A CDS//intron       -
chr17:7578511-7578512(-) m6A 5'UTR//CDS//exon       24284625//27773535
chr17:7579334-7579335(-) m6A CDS//exon//intron       24284625
chr17:7579382-7579383(-) m6A CDS//exon//intron       24284625
chr17:7579516-7579517(-) m6A CDS//exon//intron       24284625//22575960
chr17:7579533-7579534(-) m6A CDS//exon//intron       24284625//22575960
chr17:7579709-7579710(-) m6A 5'UTR//CDS//exon//intron       24284625//22575960
chr17:7579720-7579721(-) m6A 5'UTR//CDS//exon//intron       24284625//22575960
chr17:7579840-7579841(-) m6A 5'UTR//CDS//exon//intron       24284625//27371828//27773536
chr17:7579850-7579851(-) m6A 5'UTR//CDS//exon//intron       24284625//27371828//27773536
chr17:7579860-7579861(-) m6A 5'UTR//CDS//exon//intron       24284625//27371828//27773536
chr17:7579932-7579933(-) m6A 5'UTR//exon//intron       24284625//27371828//27773536
chr17:7580702-7580703(-) m6A 5'UTR//intron       24284625//24981863//27371828//27773536
chr17:7588791-7588792(-) m6A intron       27371828//27773536
chr17:7588861-7588862(-) m6A intron       27371828//27773536
chr17:7588979-7588980(-) m6A intron       24284625//25456834//24981863//27371828//22608085
chr17:7589074-7589075(-) m6A intron       24284625//25456834//24981863//22608085
chr17:7589175-7589176(-) m6A intron       24284625//24981863//27773535//22608085
chr17:7589398-7589399(-) m6A intron       24284625//22608085
chr17:7589550-7589551(-) m6A intron       22608085
chr17:7590754-7590755(-) m6A 5'UTR//exon       24284625//25456834//24981863
chr17:7590831-7590832(-) m6A 5'UTR       25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-203b-3p
Exosome Plasma     23663360
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)     -
TP53
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-203b-3p
Interactor2: TP53

Evidence Support:


Strong-Evidence Northern blot//RQ-PCR//RT-PCR//Western blot
Support Database ViRBase

References:


PMID 20702634 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line H1299 cells//HFKs cells Interactor2 expression None
Description In summary, these results indicate that expression of miR-203 is dependent on p53, which may explain how expression of HPV16 E6 can disrupt the balance between proliferation and differentiation, as well as the response to DNA damage, in keratinocytes.

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