Basic Information:
VIRBase ID: HHID00092987
Virus: Human papillomavirus type 16 (HPV16)
Host: Homo sapiens
Confidence Score: 0.9820
Interaction Type: Host-Host interaction
Predicted Binding:
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Interactor Information:
Interactor1
Interactor2
Symbol
hsa-miR-203b-5p
TP53
miRBase Accession/Entrez ID
MIMAT0019813
7157
Organism
Homo sapiens
Homo sapiens
Category
miRNA
mRNA
Alias
-
BCC7//BMFS5//LFS1//P53//TRP53
ncRNA SNP information:
Resource
Symbol
SNP ID
SNP Position
Ref/Alt
miRNASNP-v3
hsa-miR-203b-5p
RNA Editing:
Resource
Symbol
Editing Position
Lncediting
TP53
Resource
Symbol
Editing Position
Change
Genetic Region
RADAR
TP53
Resource
Symbol
Editing Position
Change
SeqReg
exReg
PMID
DARNED
TP53
RNA Modification:
Resource
Symbol
ModificationPosition
Type
Genomic Context
PMID
RMBase
TP53
RNA Localization:
Resource
Symbol
Subcellular Localization
Tissue or Cell Line
PMID
RNALocate
hsa-miR-203b-5p
TP53
Interaction Network (The top 100 interactions) :
Interactor1: hsa-miR-203b-5p
Interactor2: TP53
Evidence Support:
Strong-Evidence
Northern blot//RQ-PCR//RT-PCR//Western blot
Support Database
ViRBase
References:
PMID
20702634
Target region
3'UTR
Source
ViRBase
Interactor1 expression
Upregulation
Tissue or cell line
H1299 cells//HFKs cells
Interactor2 expression
None
Description
In summary, these results indicate that expression of miR-203 is dependent on p53, which may explain how expression of HPV16 E6 can disrupt the balance between proliferation and differentiation, as well as the response to DNA damage, in keratinocytes.