Detail Information

Basic Information:


  VIRBase ID:  

HHID00092961

  Virus:  

Influenza A virus (A/swine/Guangxi/NS2783/2010(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.9124

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-140-5p:           SCARB2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-140-5p SCARB2
miRBase
Accession/Entrez ID		 MIMAT0000431 950
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AMRF//CD36L2//EPM4//HLGP85//LGP85//LIMP-2//LIMPII//SR-BII

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-140-5p
rs1022466820 chr16:69933118    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SCARB2
chr4:77111405(-) A-I      intronic
chr4:77113040(-) A-I      intronic
chr4:77113062(-) A-I      intronic
chr4:77113068(-) A-I      intronic
chr4:77113080(-) A-I      intronic
chr4:77113103(-) A-I      intronic
chr4:77111362(-) A-I      intronic
chr4:77113905(-) A-I      intronic
chr4:77113961(-) A-I      intronic
chr4:77113972(-) A-I      intronic
chr4:77104068(-) A-I      intronic
chr4:77104052(-) A-I      intronic
chr4:77104044(-) A-I      intronic
chr4:77111381(-) A-I      intronic
chr4:77104043(-) A-I      intronic
chr4:77111359(-) A-I      intronic
chr4:77111358(-) A-I      intronic
chr4:77105878(-) A-I      intronic
chr4:77105867(-) A-I      intronic
chr4:77105866(-) A-I      intronic
chr4:77113948(-) A-I      intronic
chr4:77113923(-) A-I      intronic
chr4:77113175(-) A-I      intronic
chr4:77111861(-) A-I      intronic
chr4:77105901(-) A-I      intronic
chr4:77105872(-) A-I      intronic
chr4:77104038(-) A-I      intronic
chr4:77110867(-) A-I      intronic
chr4:77115394(-) A-I      intronic
chr4:77080712(-) A-I      3'UTR
chr4:77080695(-) A-I      3'UTR
chr4:77080692(-) A-I      3'UTR
chr4:77080683(-) A-I      3'UTR
chr4:77080642(-) A-I      3'UTR
chr4:77100433(-) A-I      intronic
chr4:77110871(-) A-I      intronic
chr4:77113197(-) A-I      intronic
chr4:77111290(-) A-I      intronic
chr4:77110752(-) A-I      intronic
chr4:77105852(-) A-I      intronic
chr4:77080860(-) A-I      3'UTR
chr4:77110732(-) A-I      intronic
chr4:77110683(-) A-I      intronic
chr4:77113191(-) A-I      intronic
chr4:77111344(-) A-I      intronic
chr4:77113196(-) A-I      intronic
chr4:77102991(-) A-I      intronic
chr4:77111438(-) A-I      intronic
chr4:77105853(-) A-I      intronic
chr4:77111395(-) A-I      intronic
chr4:77111435(-) A-I      intronic
chr4:77116511(-) A-I      intronic
chr4:77102975(-) A-I      intronic
chr4:77105928(-) A-I      intronic
chr4:77113093(-) A-I      intronic
chr4:77105927(-) A-I      intronic
chr4:77110880(-) A-I      intronic
chr4:77124260(-) A-I      intronic
chr4:77102790(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SCARB2
chr4:77080771(-) A-T exon 3'UTR    21725310
chr4:77115309(-) A-G intron -    22484847
chr4:77102991(-) A-G intron -    22484847
chr4:77103005(-) A-G intron -    22484847
chr4:77110823(-) A-G intron -    22484847
chr4:77111837(-) A-G intron -    22484847
chr4:77113889(-) A-G intron -    22484847
chr4:77113974(-) A-G intron -    22484847
chr4:77116511(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SCARB2
chr4:77082728-77082729(-) m6A 3'UTR       24981863
chr4:77082752-77082753(-) m6A 3'UTR       24981863
chr4:77082800-77082801(-) m6A 3'UTR       24981863//27371828
chr4:77082840-77082841(-) m6A 3'UTR       27371828
chr4:77134591-77134592(-) Gm CDS       -
chr4:77134828-77134829(-) m6A 5'UTR       27773536
chr4:77134921-77134922(-) m6A 5'UTR       24981863//27773536
chr4:77134927-77134928(-) m6A 5'UTR       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-140-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Cerebrospinal fluid     25420022
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Neural progenitor cells     21363885
SCARB2
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-140-5p
Bis-A-tda 97676 Drug resistant
Morpholine-N-dithiocarbamate 72675 Drug resistant
3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug resistant
Xestin A 5352066 Drug resistant
Hydroxy AT 125 5351254 Drug resistant
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Free base of NSC 610966 355990 Drug resistant
Ellipticine 3213 Drug resistant
1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug sensitive
Nile Blue 2B 20520 Drug resistant
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
8-Azaguanine 135403646 Drug sensitive
Dabequine 124332 Drug resistant
ovb3-pe - Drug resistant
piceatannol, 4,3',5'-trimethyl,1s0 - Drug sensitive
Chlorozotocin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-140-5p
Curcumin 969516 Drug interaction    RC00002786
Formaldehyde 712 Drug interaction    RC00002774
Gemcitabine 60750 Drug interaction    RC00002782
Vorinostat 5311 Drug interaction    RC00002778
Imatinib 5291 Drug interaction    RC00002777
Paclitaxel 36314 Drug interaction    RC00002781
5-Fluorouracil 3385 Drug interaction    RC00002776
Doxorubicin 31703 Drug interaction    RC00002780
Verapamil 2520 Drug interaction    RC00002775
Erlotinib 176870 Drug interaction    RC00002785
Arsenic trioxide 14888 Drug interaction    RC00002779
Methotrexate 126941 Drug interaction    RC00002784
Gefitinib 123631 Drug interaction    RC00002783
Anakinra - Drug interaction    RC00002787
Glucocorticoid - Drug interaction    RC00002788
Chemotherapy - Drug interaction    RC00008844
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-140-5p
Melphalan 460612       30121664
Doxorubicin 31703       25698578
Doxorubicin 31703       28341864
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-140-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719
Dovitinib       135398510

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-140-5p
Interactor2: SCARB2

Evidence Support:


Strong-Evidence qRT-PCR
Weak-Evidence Deep sequencing//Microarray
Prediction-Evidence microRNA.org//PITA//Targetscan
Support Database ViRBase

References:


PMID 31207403 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Relationships between 4 miRNAs and 5 inversely correlated target genes selected in qRT-PCR.

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