Detail Information

Basic Information:


  VIRBase ID:  

HHID00092959

  Virus:  

Influenza A virus (A/swine/Guangxi/NS2783/2010(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.9124

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-96-5p:           SCARB2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-96-5p SCARB2
miRBase
Accession/Entrez ID		 MIMAT0000095 950
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AMRF//CD36L2//EPM4//HLGP85//LGP85//LIMP-2//LIMPII//SR-BII

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-96-5p
rs1333938704 chr7:129774745    A/G
rs1483018024 chr7:129774750    G/A
rs772409471 chr7:129774748    G/A
rs776335197 chr7:129774752    T/C
rs957232317 chr7:129774742    A/T
rs587776522 chr7:129774757    C/T
rs587776523 chr7:129774756    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SCARB2
chr4:77111405(-) A-I      intronic
chr4:77113040(-) A-I      intronic
chr4:77113062(-) A-I      intronic
chr4:77113068(-) A-I      intronic
chr4:77113080(-) A-I      intronic
chr4:77113103(-) A-I      intronic
chr4:77111362(-) A-I      intronic
chr4:77113905(-) A-I      intronic
chr4:77113961(-) A-I      intronic
chr4:77113972(-) A-I      intronic
chr4:77104068(-) A-I      intronic
chr4:77104052(-) A-I      intronic
chr4:77104044(-) A-I      intronic
chr4:77111381(-) A-I      intronic
chr4:77104043(-) A-I      intronic
chr4:77111359(-) A-I      intronic
chr4:77111358(-) A-I      intronic
chr4:77105878(-) A-I      intronic
chr4:77105867(-) A-I      intronic
chr4:77105866(-) A-I      intronic
chr4:77113948(-) A-I      intronic
chr4:77113923(-) A-I      intronic
chr4:77113175(-) A-I      intronic
chr4:77111861(-) A-I      intronic
chr4:77105901(-) A-I      intronic
chr4:77105872(-) A-I      intronic
chr4:77104038(-) A-I      intronic
chr4:77110867(-) A-I      intronic
chr4:77115394(-) A-I      intronic
chr4:77080712(-) A-I      3'UTR
chr4:77080695(-) A-I      3'UTR
chr4:77080692(-) A-I      3'UTR
chr4:77080683(-) A-I      3'UTR
chr4:77080642(-) A-I      3'UTR
chr4:77100433(-) A-I      intronic
chr4:77110871(-) A-I      intronic
chr4:77113197(-) A-I      intronic
chr4:77111290(-) A-I      intronic
chr4:77110752(-) A-I      intronic
chr4:77105852(-) A-I      intronic
chr4:77080860(-) A-I      3'UTR
chr4:77110732(-) A-I      intronic
chr4:77110683(-) A-I      intronic
chr4:77113191(-) A-I      intronic
chr4:77111344(-) A-I      intronic
chr4:77113196(-) A-I      intronic
chr4:77102991(-) A-I      intronic
chr4:77111438(-) A-I      intronic
chr4:77105853(-) A-I      intronic
chr4:77111395(-) A-I      intronic
chr4:77111435(-) A-I      intronic
chr4:77116511(-) A-I      intronic
chr4:77102975(-) A-I      intronic
chr4:77105928(-) A-I      intronic
chr4:77113093(-) A-I      intronic
chr4:77105927(-) A-I      intronic
chr4:77110880(-) A-I      intronic
chr4:77124260(-) A-I      intronic
chr4:77102790(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SCARB2
chr4:77080771(-) A-T exon 3'UTR    21725310
chr4:77115309(-) A-G intron -    22484847
chr4:77102991(-) A-G intron -    22484847
chr4:77103005(-) A-G intron -    22484847
chr4:77110823(-) A-G intron -    22484847
chr4:77111837(-) A-G intron -    22484847
chr4:77113889(-) A-G intron -    22484847
chr4:77113974(-) A-G intron -    22484847
chr4:77116511(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SCARB2
chr4:77082728-77082729(-) m6A 3'UTR       24981863
chr4:77082752-77082753(-) m6A 3'UTR       24981863
chr4:77082800-77082801(-) m6A 3'UTR       24981863//27371828
chr4:77082840-77082841(-) m6A 3'UTR       27371828
chr4:77134591-77134592(-) Gm CDS       -
chr4:77134828-77134829(-) m6A 5'UTR       27773536
chr4:77134921-77134922(-) m6A 5'UTR       24981863//27773536
chr4:77134927-77134928(-) m6A 5'UTR       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-96-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Peripheral blood mononuclear cells     19002258
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Seminal fluid|Tongue tissue     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
SCARB2
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-96-5p
(10S,13S,16S,19S)-16-Butan-2-yl-10,11,14-trimethyl-3-(oxiran-2-ylmethyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 152771884 Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-96-5p
Gemcitabine 60750 Drug interaction    RC00001021
Clopidogrel 60606 Drug interaction    RC00001020
Cholesterol 5997 Drug interaction    RC00001016
D-Glucose 5793 Drug interaction    RC00001015
Vorinostat 5311 Drug interaction    RC00001014
Imatinib 5291 Drug interaction    RC00001013
Paclitaxel 36314 Drug interaction    RC00001019
5-Fluorouracil 3385 Drug interaction    RC00001012
Enoxacin 3229 Drug interaction    RC00001011
Doxorubicin 31703 Drug interaction    RC00001018
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001010
Tamoxifen 2733526 Drug interaction    RC00001023
Verapamil 2520 Drug interaction    RC00001009
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001025
Olaparib 23725625 Drug interaction    RC00001024
Arsenic trioxide 14888 Drug interaction    RC00001017
Docetaxel 148124 Drug interaction    RC00001022
Chemotherapy - Drug interaction    RC00008826
TRAIL therapy - Drug interaction    RC00001026
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-96-5p
Oxaliplatin 9887053       31089750
Paclitaxel 36314       26323677
5-Fluorouracil 3385       31089750
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-96-5p
Interactor2: SCARB2

Evidence Support:


Strong-Evidence qRT-PCR
Weak-Evidence Deep sequencing//Microarray
Prediction-Evidence microRNA.org//PITA//Targetscan
Support Database ViRBase

References:


PMID 31207403 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Relationships between 4 miRNAs and 5 inversely correlated target genes selected in qRT-PCR.

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