Basic Information:

  VIRBase ID:  

HHID00092958

  Virus:  

Influenza A virus (A/swine/Guangxi/NS2783/2010(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.9124

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30a-3p:  MIMAT0000088          RANBP1:  NM_002882     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30a-3p	RANBP1
miRBase Accession/Entrez ID	MIMAT0000088	5902
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HTF9A

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30a-3p	rs149150037 chr6:71403567    G/A rs149150037 chr6:71403567    G/C rs370184894 chr6:71403566    C/A rs370184894 chr6:71403566    C/T rs552541514 chr6:71403558    C/G rs745605208 chr6:71403563    ATCCG/A rs746505574 chr6:71403557    G/A rs746505574 chr6:71403557    G/T rs746965145 chr6:71403554    GCT/G rs750918072 chr6:71403564    T/C rs765735953 chr6:71403560    A/T rs770865356 chr6:71403559    A/AC rs776574456 chr6:71403560    A/AAGCTGGAGT rs368070339 chr6:71403571    G/A rs769702885 chr6:71403570    TG/T rs775921090 chr6:71403574    AGCC/A rs781617967 chr6:71403573    A/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RANBP1	chr22:20103494-20103495(+) m6A 5'UTR       22608085 chr22:20103558-20103559(+) Am 5'UTR       - chr22:20103868-20103869(+) m6A CDS       24284625//25456834//24981863//27371828//27773536//22575960//22608085 chr22:20105485-20105486(+) m6A 5'UTR//intron       25456834 chr22:20105743-20105744(+) m6A 5'UTR//intron       24209618 chr22:20105819-20105820(+) m6A 5'UTR//intron       24209618//27773535 chr22:20106548-20106549(+) m6A 3'UTR//5'UTR//CDS//exon       24209618//24981863//27773535 chr22:20106637-20106638(+) m6A 3'UTR//5'UTR//CDS//exon       24209618//24981863//27773535 chr22:20106660-20106661(+) m6A 3'UTR//5'UTR//CDS//exon       24209618//24981863//27773535 chr22:20106700-20106701(+) m6A exon//intron       24209618//24981863//27773535 chr22:20106763-20106764(+) m6A exon//intron       24981863 chr22:20107006-20107007(+) m6A exon//intron       - chr22:20109795-20109796(+) m6A 3'UTR//CDS//exon       - chr22:20109911-20109912(+) m6A 3'UTR//CDS//exon       22575960 chr22:20109916-20109917(+) m6A 3'UTR//CDS//exon       22575960 chr22:20109994-20109995(+) m6A exon//intron       - chr22:20112887-20112888(+) m6A 3'UTR//CDS//exon       - chr22:20112979-20112980(+) m6A CDS//intron       24981863//27773535//22575960 chr22:20113842-20113843(+) m6A 3'UTR//CDS//exon       25456834//24981863//27773535 chr22:20113928-20113929(+) m6A 3'UTR//CDS//exon//intron       25456834//24981863//27773535 chr22:20113985-20113986(+) m6A 3'UTR//CDS//exon//intron       25456834//24981863//27773535 chr22:20114401-20114402(+) m6A 3'UTR//exon//intron       24981863 chr22:20114545-20114546(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr22:20114695-20114696(+) m6A 3'UTR//exon       27773535 chr22:20114700-20114701(+) m6A 3'UTR//exon       27773535 chr22:20114823-20114824(+) m6A 3'UTR//exon       27773535 chr22:20114860-20114861(+) m6A 3'UTR//exon       27773535 chr22:20114871-20114872(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30a-3p	Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Endothelial cells|Epithelial cells|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Serum     24797360 Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	RANBP1	Chromatin HCC cell line (HepG2)|K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm HCC cell line (HepG2)|K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30a-3p	Sorafenib 216239 Drug interaction    RC00000903

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30a-3p	Imatinib 5291       25349971

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30a-3p
Interactor2: RANBP1

Evidence Support:

Strong-Evidence	qRT-PCR
Weak-Evidence	Deep sequencing//Microarray
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	31207403	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Relationships between 4 miRNAs and 5 inversely correlated target genes selected in qRT-PCR.