Detail Information
Interactor1 | Interactor2 | |
---|---|---|
Symbol | hsa-miR-146a-3p | TRAF6 |
miRBase Accession/Entrez ID |
MIMAT0004608 | 7189 |
Organism | Homo sapiens | Homo sapiens |
Category | miRNA | mRNA |
Alias | - | MGC:3310//RNF85 |
Resource | Symbol | SNP ID | SNP Position | Ref/Alt | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
miRNASNP-v3 | hsa-miR-146a-3p |
|
Resource | Symbol | Editing Position | Change | Genetic Region | ||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RADAR | TRAF6 |
|
Resource | Symbol | Editing Position | Change | SeqReg | exReg | PMID | |||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DARNED | TRAF6 |
|
Resource | Symbol | ModificationPosition | Type | Genomic Context | PMID | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RMBase | TRAF6 |
|
Resource | Symbol | Subcellular Localization | Tissue or Cell Line | PMID | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RNALocate | hsa-miR-146a-3p |
|
|||||||||||
TRAF6 |
Interactor1: hsa-miR-146a-3p | Interactor2: TRAF6 |
---|
Strong-Evidence | Luciferase assay//Luciferase reporter assay//qPCR//Western blot | |
---|---|---|
Prediction-Evidence | PicTar//Targetscan | |
Support Database | ViRBase |
[1]PMID | 30611999 | Target region | 3'UTR |
---|---|---|---|
Source | ViRBase | Interactor1 expression | Upregulation |
Tissue or cell line | A549 cells//HEK 293 cells | Interactor2 expression | None |
Description | However, when miR-146a inhibitor was applied, recovery of TRAF6 expression was observed upon IAV H1N1 infection (Fig. 5E), suggesting that IAV infection downregulates TRAF6 by upregulating miR-146a. |
[2]PMID | 31638222 | Target region | 3'UTR |
---|---|---|---|
Source | ViRBase | Interactor1 expression | Upregulation |
Tissue or cell line | A549 cells | Interactor2 expression | Downregulation |
Description | Together, our findings indicate that TRAF6 is a direct target of miR-146a in A549 cells during infection of H1N1 and H3N2. |