Basic Information:

  VIRBase ID:  

HHID00092945

  Virus:  

Influenza A virus (A/Hong Kong/498/97 (H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.9820

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-590-5p:  MIMAT0003258          IL6R:  NM_001206866     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-590-5p	IL6R
miRBase Accession/Entrez ID	MIMAT0003258	3570
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD126//gp80//HIES5//IL-1Ra//IL-6R//IL-6R-1//IL-6RA//IL6Q//IL6QTL//IL6RA//IL6RQ

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-590-5p	rs1554709898 chr7:74191225    A/G rs192756765 chr7:74191221    T/A rs781995768 chr7:74191223    A/G rs782101000 chr7:74191229    G/A rs189727189 chr7:74191216    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IL6R	chr1:154425523(+) A-I      intronic chr1:154425485(+) A-I      intronic chr1:154439146(+) A-I      3'UTR chr1:154421804(+) A-I      intronic chr1:154439145(+) A-I      3'UTR chr1:154439190(+) A-I      3'UTR chr1:154439174(+) A-I      3'UTR chr1:154439153(+) A-I      3'UTR chr1:154425120(+) A-I      intronic chr1:154425119(+) A-I      intronic chr1:154406553(+) A-I      intronic chr1:154425104(+) A-I      intronic chr1:154425079(+) A-I      intronic chr1:154424273(+) A-I      intronic chr1:154406226(+) A-I      intronic chr1:154424217(+) A-I      intronic chr1:154424195(+) A-I      intronic chr1:154424192(+) A-I      intronic chr1:154388897(+) A-I      intronic chr1:154424168(+) A-I      intronic chr1:154424130(+) A-I      intronic chr1:154423901(+) A-I      intronic chr1:154423851(+) A-I      intronic chr1:154423847(+) A-I      intronic chr1:154423832(+) A-I      intronic chr1:154388895(+) A-I      intronic chr1:154423829(+) A-I      intronic chr1:154423823(+) A-I      intronic chr1:154423808(+) A-I      intronic chr1:154423793(+) A-I      intronic chr1:154423792(+) A-I      intronic chr1:154422880(+) A-I      intronic chr1:154422802(+) A-I      intronic chr1:154422701(+) A-I      intronic chr1:154388873(+) A-I      intronic chr1:154422679(+) A-I      intronic chr1:154422666(+) A-I      intronic chr1:154422007(+) A-I      intronic chr1:154421993(+) A-I      intronic chr1:154421985(+) A-I      intronic chr1:154421979(+) A-I      intronic chr1:154421968(+) A-I      intronic chr1:154421766(+) A-I      intronic chr1:154421762(+) A-I      intronic chr1:154421752(+) A-I      intronic chr1:154421729(+) A-I      intronic chr1:154421444(+) A-I      intronic chr1:154421425(+) A-I      intronic chr1:154420373(+) A-I      intronic chr1:154420270(+) A-I      intronic chr1:154420252(+) A-I      intronic chr1:154419840(+) A-I      intronic chr1:154419823(+) A-I      intronic chr1:154419821(+) A-I      intronic chr1:154419792(+) A-I      intronic chr1:154419753(+) A-I      intronic chr1:154419750(+) A-I      intronic chr1:154419719(+) A-I      intronic chr1:154419514(+) A-I      intronic chr1:154388745(+) A-I      intronic chr1:154418431(+) A-I      intronic chr1:154418426(+) A-I      intronic chr1:154418105(+) A-I      intronic chr1:154417977(+) A-I      intronic chr1:154417971(+) A-I      intronic chr1:154388735(+) A-I      intronic chr1:154417349(+) A-I      intronic chr1:154388255(+) A-I      intronic chr1:154417245(+) A-I      intronic chr1:154417217(+) A-I      intronic chr1:154417132(+) A-I      intronic chr1:154417124(+) A-I      intronic chr1:154388193(+) A-I      intronic chr1:154384823(+) A-I      intronic chr1:154416904(+) A-I      intronic chr1:154416884(+) A-I      intronic chr1:154416789(+) A-I      intronic chr1:154416788(+) A-I      intronic chr1:154384810(+) A-I      intronic chr1:154416741(+) A-I      intronic chr1:154415369(+) A-I      intronic chr1:154413419(+) A-I      intronic chr1:154413403(+) A-I      intronic chr1:154413391(+) A-I      intronic chr1:154413312(+) A-I      intronic chr1:154413303(+) A-I      intronic chr1:154384517(+) A-I      intronic chr1:154412562(+) A-I      intronic chr1:154412482(+) A-I      intronic chr1:154412478(+) A-I      intronic chr1:154412459(+) A-I      intronic chr1:154384331(+) A-I      intronic chr1:154412406(+) A-I      intronic chr1:154412038(+) A-I      intronic chr1:154410331(+) A-I      intronic chr1:154410319(+) A-I      intronic chr1:154384328(+) A-I      intronic chr1:154384327(+) A-I      intronic chr1:154429720(+) A-I      intronic chr1:154437314(+) A-I      intronic chr1:154383659(+) A-I      intronic chr1:154437285(+) A-I      intronic chr1:154437220(+) A-I      intronic chr1:154437180(+) A-I      intronic chr1:154436756(+) A-I      intronic chr1:154383639(+) A-I      intronic chr1:154436735(+) A-I      intronic chr1:154383634(+) A-I      intronic chr1:154408875(+) A-I      intronic chr1:154436731(+) A-I      intronic chr1:154381516(+) A-I      intronic chr1:154436692(+) A-I      intronic chr1:154436651(+) A-I      intronic chr1:154436649(+) A-I      intronic chr1:154429786(+) A-I      intronic chr1:154381502(+) A-I      intronic chr1:154429749(+) A-I      intronic chr1:154408804(+) A-I      intronic chr1:154408803(+) A-I      intronic chr1:154429748(+) A-I      intronic chr1:154429731(+) A-I      intronic chr1:154429724(+) A-I      intronic chr1:154429710(+) A-I      intronic chr1:154406689(+) A-I      intronic chr1:154429705(+) A-I      intronic chr1:154429702(+) A-I      intronic chr1:154429679(+) A-I      intronic chr1:154429649(+) A-I      intronic chr1:154429639(+) A-I      intronic chr1:154429638(+) A-I      intronic chr1:154429613(+) A-I      intronic chr1:154429612(+) A-I      intronic chr1:154406554(+) A-I      intronic chr1:154429609(+) A-I      intronic chr1:154429589(+) A-I      intronic chr1:154429570(+) A-I      intronic chr1:154429544(+) A-I      intronic chr1:154428966(+) A-I      intronic chr1:154428957(+) A-I      intronic chr1:154428782(+) A-I      intronic chr1:154428781(+) A-I      intronic chr1:154428046(+) A-I      intronic chr1:154427661(+) A-I      intronic chr1:154427502(+) A-I      intronic chr1:154425638(+) A-I      intronic chr1:154425622(+) A-I      intronic chr1:154425602(+) A-I      intronic chr1:154425593(+) A-I      intronic chr1:154425592(+) A-I      intronic chr1:154425570(+) A-I      intronic chr1:154425502(+) A-I      intronic chr1:154425431(+) A-I      intronic chr1:154425425(+) A-I      intronic chr1:154425160(+) A-I      intronic chr1:154425153(+) A-I      intronic chr1:154429579(+) A-I      intronic chr1:154384237(+) A-I      intronic chr1:154413364(+) A-I      intronic chr1:154409666(+) A-I      intronic chr1:154427580(+) A-I      intronic chr1:154429678(+) A-I      intronic chr1:154425466(+) A-I      intronic chr1:154408940(+) A-I      intronic chr1:154427431(+) A-I      intronic chr1:154406224(+) A-I      intronic chr1:154416858(+) A-I      intronic chr1:154417211(+) A-I      intronic chr1:154417320(+) A-I      intronic chr1:154406402(+) A-I      intronic chr1:154429535(+) A-I      intronic chr1:154417192(+) A-I      intronic chr1:154424152(+) A-I      intronic chr1:154424198(+) A-I      intronic chr1:154415395(+) A-I      intronic chr1:154406291(+) A-I      intronic chr1:154417294(+) A-I      intronic chr1:154420412(+) A-I      intronic chr1:154413338(+) A-I      intronic chr1:154419496(+) A-I      intronic chr1:154409702(+) A-I      intronic chr1:154425465(+) A-I      intronic chr1:154416754(+) A-I      intronic chr1:154422799(+) A-I      intronic chr1:154419713(+) A-I      intronic chr1:154417096(+) A-I      intronic chr1:154437173(+) A-I      intronic chr1:154408807(+) A-I      intronic chr1:154416785(+) A-I      intronic chr1:154409604(+) A-I      intronic chr1:154417116(+) A-I      intronic chr1:154412479(+) A-I      intronic chr1:154417258(+) A-I      intronic chr1:154424212(+) A-I      intronic chr1:154422719(+) A-I      intronic chr1:154412065(+) A-I      intronic chr1:154428278(+) A-I      intronic chr1:154437328(+) A-I      intronic chr1:154406633(+) A-I      intronic chr1:154418115(+) A-I      intronic chr1:154417252(+) A-I      intronic chr1:154419714(+) A-I      intronic chr1:154406477(+) A-I      intronic chr1:154406471(+) A-I      intronic chr1:154429550(+) A-I      intronic chr1:154437398(+) A-I      intronic chr1:154415481(+) A-I      intronic chr1:154421801(+) A-I      intronic chr1:154425528(+) A-I      intronic chr1:154408919(+) A-I      intronic chr1:154428413(+) A-I      intronic chr1:154437202(+) A-I      intronic chr1:154427419(+) A-I      intronic chr1:154428454(+) A-I      intronic chr1:154428430(+) A-I      intronic chr1:154429597(+) A-I      intronic chr1:154429634(+) A-I      intronic chr1:154424274(+) A-I      intronic chr1:154418515(+) A-I      intronic chr1:154425221(+) A-I      intronic chr1:154428482(+) A-I      intronic chr1:154420364(+) A-I      intronic chr1:154420308(+) A-I      intronic chr1:154413351(+) A-I      intronic chr1:154437229(+) A-I      intronic chr1:154406625(+) A-I      intronic chr1:154437344(+) A-I      intronic chr1:154425534(+) A-I      intronic chr1:154412544(+) A-I      intronic chr1:154423739(+) A-I      intronic chr1:154418438(+) A-I      intronic chr1:154425186(+) A-I      intronic chr1:154388226(+) A-I      intronic chr1:154417242(+) A-I      intronic chr1:154409712(+) A-I      intronic chr1:154413290(+) A-I      intronic chr1:154421869(+) A-I      intronic chr1:154437251(+) A-I      intronic chr1:154417321(+) A-I      intronic chr1:154437324(+) A-I      intronic chr1:154419768(+) A-I      intronic chr1:154413390(+) A-I      intronic chr1:154429566(+) A-I      intronic chr1:154421654(+) A-I      intronic chr1:154437188(+) A-I      intronic chr1:154388302(+) A-I      intronic chr1:154422862(+) A-I      intronic chr1:154425558(+) A-I      intronic chr1:154410216(+) A-I      intronic chr1:154427483(+) A-I      intronic chr1:154419555(+) A-I      intronic chr1:154415376(+) A-I      intronic chr1:154428422(+) A-I      intronic chr1:154437284(+) A-I      intronic chr1:154408800(+) A-I      intronic chr1:154415434(+) A-I      intronic chr1:154413309(+) A-I      intronic chr1:154398444(+) A-I      intronic chr1:154416764(+) A-I      intronic chr1:154427556(+) A-I      intronic chr1:154425521(+) A-I      intronic chr1:154427999(+) A-I      intronic chr1:154428110(+) A-I      intronic chr1:154408944(+) A-I      intronic chr1:154428412(+) A-I      intronic chr1:154427607(+) A-I      intronic chr1:154428380(+) A-I      intronic chr1:154437179(+) A-I      intronic chr1:154421450(+) A-I      intronic chr1:154421842(+) A-I      intronic chr1:154408834(+) A-I      intronic chr1:154415289(+) A-I      intronic chr1:154425192(+) A-I      intronic chr1:154383615(+) A-I      intronic chr1:154421805(+) A-I      intronic chr1:154428371(+) A-I      intronic chr1:154409959(+) A-I      intronic chr1:154415294(+) A-I      intronic chr1:154408797(+) A-I      intronic chr1:154420292(+) A-I      intronic chr1:154429552(+) A-I      intronic chr1:154437350(+) A-I      intronic chr1:154437361(+) A-I      intronic chr1:154417232(+) A-I      intronic chr1:154429637(+) A-I      intronic chr1:154415307(+) A-I      intronic chr1:154408906(+) A-I      intronic chr1:154428799(+) A-I      intronic chr1:154408833(+) A-I      intronic chr1:154428483(+) A-I      intronic chr1:154417328(+) A-I      intronic chr1:154416957(+) A-I      intronic chr1:154386499(+) A-I      intronic chr1:154418151(+) A-I      intronic chr1:154417980(+) A-I      intronic chr1:154428113(+) A-I      intronic chr1:154415332(+) A-I      intronic chr1:154428439(+) A-I      intronic chr1:154425531(+) A-I      intronic chr1:154423744(+) A-I      intronic chr1:154429530(+) A-I      intronic chr1:154422874(+) A-I      intronic chr1:154384833(+) A-I      intronic chr1:154384269(+) A-I      intronic chr1:154425520(+) A-I      intronic chr1:154437391(+) A-I      intronic chr1:154427663(+) A-I      intronic chr1:154425053(+) A-I      intronic chr1:154435449(+) A-I      intronic chr1:154418424(+) A-I      intronic chr1:154412553(+) A-I      intronic chr1:154417288(+) A-I      intronic chr1:154413232(+) A-I      intronic chr1:154406407(+) A-I      intronic chr1:154429640(+) A-I      intronic chr1:154436687(+) A-I      intronic chr1:154406292(+) A-I      intronic chr1:154437279(+) A-I      intronic chr1:154420447(+) A-I      intronic chr1:154425525(+) A-I      intronic chr1:154419646(+) A-I      intronic chr1:154383635(+) A-I      intronic chr1:154428857(+) A-I      intronic chr1:154420247(+) A-I      intronic chr1:154417191(+) A-I      intronic chr1:154428373(+) A-I      intronic chr1:154428372(+) A-I      intronic chr1:154412518(+) A-I      intronic chr1:154429598(+) A-I      intronic chr1:154388200(+) A-I      intronic chr1:154427555(+) A-I      intronic chr1:154412569(+) A-I      intronic chr1:154424286(+) A-I      intronic chr1:154425522(+) A-I      intronic chr1:154417972(+) A-I      intronic chr1:154417299(+) A-I      intronic chr1:154417965(+) A-I      intronic chr1:154388393(+) A-I      intronic chr1:154416867(+) A-I      intronic chr1:154420291(+) A-I      intronic chr1:154413329(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IL6R	chr1:154383615(+) A-G intron -    22484847 chr1:154383635(+) A-G intron -    22484847 chr1:154384237(+) A-G intron -    22484847 chr1:154384269(+) A-G intron -    22484847 chr1:154388200(+) A-G intron -    22484847 chr1:154388226(+) A-G intron -    22484847 chr1:154388302(+) A-G intron -    22484847 chr1:154406224(+) A-G intron -    22484847 chr1:154406291(+) A-G intron -    22484847 chr1:154406292(+) A-G intron -    22484847 chr1:154406402(+) A-G intron -    22484847 chr1:154406407(+) A-G intron -    22484847 chr1:154406625(+) A-G intron -    22484847 chr1:154408800(+) A-G intron -    22484847 chr1:154408833(+) A-G intron -    22484847 chr1:154408834(+) A-G intron -    22484847 chr1:154413149(+) G-T intron -    22484847 chr1:154413150(+) A-T intron -    22484847 chr1:154413232(+) A-G intron -    22484847 chr1:154413309(+) A-G intron -    22484847 chr1:154415307(+) A-G intron -    22484847 chr1:154416754(+) A-G intron -    22484847 chr1:154416785(+) A-G intron -    22484847 chr1:154416858(+) A-G intron -    22484847 chr1:154416867(+) A-G intron -    22484847 chr1:154417094(+) T-C intron -    22484847 chr1:154417096(+) A-G intron -    22484847 chr1:154417258(+) A-G intron -    22484847 chr1:154417294(+) A-G intron -    22484847 chr1:154417320(+) A-G intron -    22484847 chr1:154417328(+) A-G intron -    22484847 chr1:154417965(+) A-G intron -    22484847 chr1:154418424(+) A-G intron -    22484847 chr1:154418438(+) A-G intron -    22484847 chr1:154419555(+) A-G intron -    22484847 chr1:154419646(+) A-G intron -    22484847 chr1:154419713(+) A-G intron -    22484847 chr1:154420247(+) A-G intron -    22484847 chr1:154420292(+) A-G intron -    22484847 chr1:154420308(+) A-G intron -    22484847 chr1:154420364(+) A-G intron -    22484847 chr1:154420412(+) A-G intron -    22484847 chr1:154421869(+) A-G intron -    22484847 chr1:154422799(+) A-G intron -    22484847 chr1:154423739(+) A-G intron -    22484847 chr1:154423744(+) A-G intron -    22484847 chr1:154424132(+) C-T intron -    22484847 chr1:154424152(+) A-G intron -    22484847 chr1:154424198(+) A-G intron -    22484847 chr1:154424274(+) A-G intron -    22484847 chr1:154425186(+) A-G intron -    22484847 chr1:154425192(+) A-G intron -    22484847 chr1:154425465(+) A-G intron -    22484847 chr1:154425525(+) A-G intron -    22484847 chr1:154425558(+) A-G intron -    22484847 chr1:154427419(+) A-G intron -    22484847 chr1:154427431(+) A-G intron -    22484847 chr1:154428371(+) A-G intron -    22484847 chr1:154428372(+) A-G intron -    22484847 chr1:154428373(+) A-G intron -    22484847 chr1:154428412(+) A-G intron -    22484847 chr1:154429550(+) A-G intron -    22484847 chr1:154436642(+) A-T intron -    22484847 chr1:154437179(+) A-G intron -    22484847 chr1:154437251(+) A-G intron -    22484847 chr1:154437324(+) A-G intron -    22484847 chr1:154437328(+) A-G intron -    22484847 chr1:154437398(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IL6R	chr1:154377841-154377842(+) m6A 5'UTR       24981863 chr1:154377937-154377938(+) m6A 5'UTR       24981863 chr1:154437652-154437653(+) m6A 3'UTR//CDS//exon       24284625 chr1:154437803-154437804(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr1:154437836-154437837(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr1:154437882-154437883(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr1:154437899-154437900(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr1:154438051-154438052(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:154438092-154438093(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:154438113-154438114(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:154438124-154438125(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:154438133-154438134(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:154438145-154438146(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:154438321-154438322(+) m6A 3'UTR       24284625//25456834//24981863 chr1:154438330-154438331(+) m6A 3'UTR       24284625//25456834//24981863 chr1:154438386-154438387(+) m6A 3'UTR       24284625//24981863 chr1:154438442-154438443(+) m6A 3'UTR       24284625//24981863 chr1:154438600-154438601(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-590-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Follicular fluid     23666971 Microvesicle Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Neural progenitor cells     21363885
	IL6R	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HCC cell line (HepG2)     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-590-5p	Sensorad 99342 Drug sensitive Gardenin B 96539 Drug sensitive 2,5-Dimethyl-1,4-benzoquinone 8718 Drug sensitive Acid Green 27 80837 Drug sensitive Morpholine-N-dithiocarbamate 72675 Drug sensitive Berberine iodide 72350 Drug sensitive Sulbentine 67686 Drug sensitive Laurolinium acetate 67354 Drug sensitive Dihydroartemisinyl ether, stereoisomer of NSC-685989 6712439 Drug sensitive Acnistin F 6712173 Drug sensitive Verrucarin A 6326658 Drug sensitive Verrucarin A, 3'-(acetyloxy)-7'-deoxo-2'-deoxy-4'-hydroxy-7'-(1-hydroxyethyl)- 5933240 Drug sensitive 8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive Caracemide 54747 Drug sensitive Artelasticin 5471311 Drug sensitive (Z)-1-Iodo-2-phenyl-1-penten-3-one 5468684 Drug sensitive 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Thiram 5455 Drug sensitive (E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive Ovatifolin acetate 5358419 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive Herbimycin 5311102 Drug sensitive Vorinostat 5311 Drug sensitive 6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive Asimicinone 393461 Drug sensitive 2-(1-Propynyl)estradiol 388008 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive 4-Phenacyloxychromen-2-one 386272 Drug resistant (-)7,8-Dihydrocalanolide A 383107 Drug sensitive 1-Azido-2-phenyl-3-phenalenone 381891 Drug sensitive (1R)-3,3-Dibromocamphor 376765 Drug sensitive 3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive Antineoplastic-645804 371505 Drug sensitive 1-(4-Methoxy-2-methylphenyl)naphtho[1,2-c]furan-3(1H)-one 369148 Drug sensitive Aplidazole C . TFA 362402 Drug sensitive Thiosangivamycin 3580213 Drug sensitive Bis(helenalinyl)glutarate 336831 Drug sensitive 6-(4-Chlorophenyl)sulfanylquinazoline-2,4-diamine 328131 Drug sensitive 2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive Antimycin A3 245869 Drug sensitive (2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive [(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug sensitive Antibiotic U 29135 24196291 Drug sensitive 7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide 23635154 Drug sensitive Drostanolone propionate 224004 Drug sensitive Kinetin riboside 20345 Drug resistant Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive 4-Chloro-5-(pyridin-2-ylthio)-3H-1,2-dithiole-3-thione 16766538 Drug sensitive 4H-1,3,2-Benzodioxastannin-4-one, 7-amino-2,2-diphenyl- 16683127 Drug sensitive Dihydroartemisinin (mixture of alpha and beta isomers) 16399850 Drug sensitive Triethyltin chloride 13820 Drug sensitive Astrazon Orange R 135747272 Drug sensitive (1R,2S,5S,8S,9S,17R,18R,21S,24R,26S,27S)-14-Chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone 134715214 Drug sensitive Melampodinin 11953936 Drug sensitive Unii-C616DV5Y11 117587576 Drug sensitive Cyanoaminopyranopyridine derivatives 11494577 Drug resistant Unii-9JU14BJ5QG 109374088 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive 15,16-Dihydrocuracin A 101683509 Drug sensitive (1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive Chimaphilin 101211 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive 1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug sensitive 1h-1,4,7-triazonine-1,4,7-triacetic acid, octahydro- - Drug sensitive 1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive 1-piperidinecarbodithioic acid, antimony complex - Drug sensitive 4'-deoxy-13',17-dinitro-3',4'-epoxy-vincaleukoblastine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive 9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive anthracen-9-one, 10-[(2-methoxyphenyl)methylene]- - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive benzonitrile, 2-amino-3,5-dinitro- (9ci) - Drug sensitive cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive geldanamycin, n,n'-dimethyl - Drug sensitive gold(1+), bis(trimethylphosphine)-, chloride - Drug sensitive iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive roridin a, 8-hydroxy-9b,10b-epoxy- - Drug sensitive uridine, 5-isobutyl-2'-deoxy- - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive 1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive 2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive antineoplastic-615538 - Drug sensitive antineoplastic-644916 - Drug sensitive bavachyaone - Drug sensitive geldanamycin analog - Drug sensitive isatin dr - Drug sensitive thiadiazines - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-590-5p	Nicotine 89594 Drug interaction    RC00006067 Formaldehyde 712 Drug interaction    RC00006061 Gemcitabine 60750 Drug interaction    RC00006066 5-Fluorouracil 3385 Drug interaction    RC00006064 Doxorubicin 31703 Drug interaction    RC00006065 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006063 Verapamil 2520 Drug interaction    RC00006062 Docetaxel 148124 Drug interaction    RC00006069 Ginsenoside Rh2 119307 Drug interaction    RC00006068 SIOP treatment protocol - Drug interaction    RC00006070

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-590-5p	Cisplatin 5702198       27757042 Paclitaxel 36314       27757042 Doxorubicin 31703       30111512

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-590-5p
Interactor2: IL6R

Evidence Support:

Strong-Evidence	ELISA//Luciferase reporter assay//qRT-PCR//Western blot
Support Database	ViRBase

References:

PMID	30291142	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	A549 cells	Interactor2 expression	Downregulation
Description	Taken together, these data suggest that miR-590-5p inhibits sIL6R and mIL6R expression mainly through the translational repression mechanism.