Basic Information:

  VIRBase ID:  

HHID00092943

  Virus:  

Influenza A virus (A/Hong Kong/498/97 (H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-590-5p:  MIMAT0003258          IL1B:  NM_000576     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-590-5p	IL1B
miRBase Accession/Entrez ID	MIMAT0003258	3553
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IL-1//IL1-BETA//IL1beta//IL1F2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-590-5p	rs1554709898 chr7:74191225    A/G rs192756765 chr7:74191221    T/A rs781995768 chr7:74191223    A/G rs782101000 chr7:74191229    G/A rs189727189 chr7:74191216    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IL1B	chr2:113590257-113590258(-) m6A CDS//exon       - chr2:113590281-113590282(-) m6A CDS//exon       - chr2:113593136-113593137(-) m6A exon//intron       27371828 chr2:113593151-113593152(-) m6A CDS//exon       27371828 chr2:113594350-113594351(-) m6A 5'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-590-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Follicular fluid     23666971 Microvesicle Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Neural progenitor cells     21363885
	IL1B	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-590-5p	Sensorad 99342 Drug sensitive Gardenin B 96539 Drug sensitive 2,5-Dimethyl-1,4-benzoquinone 8718 Drug sensitive Acid Green 27 80837 Drug sensitive Morpholine-N-dithiocarbamate 72675 Drug sensitive Berberine iodide 72350 Drug sensitive Sulbentine 67686 Drug sensitive Laurolinium acetate 67354 Drug sensitive Dihydroartemisinyl ether, stereoisomer of NSC-685989 6712439 Drug sensitive Acnistin F 6712173 Drug sensitive Verrucarin A 6326658 Drug sensitive Verrucarin A, 3'-(acetyloxy)-7'-deoxo-2'-deoxy-4'-hydroxy-7'-(1-hydroxyethyl)- 5933240 Drug sensitive 8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive Caracemide 54747 Drug sensitive Artelasticin 5471311 Drug sensitive (Z)-1-Iodo-2-phenyl-1-penten-3-one 5468684 Drug sensitive 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Thiram 5455 Drug sensitive (E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive Ovatifolin acetate 5358419 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive Herbimycin 5311102 Drug sensitive Vorinostat 5311 Drug sensitive 6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive Asimicinone 393461 Drug sensitive 2-(1-Propynyl)estradiol 388008 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive 4-Phenacyloxychromen-2-one 386272 Drug resistant (-)7,8-Dihydrocalanolide A 383107 Drug sensitive 1-Azido-2-phenyl-3-phenalenone 381891 Drug sensitive (1R)-3,3-Dibromocamphor 376765 Drug sensitive 3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive Antineoplastic-645804 371505 Drug sensitive 1-(4-Methoxy-2-methylphenyl)naphtho[1,2-c]furan-3(1H)-one 369148 Drug sensitive Aplidazole C . TFA 362402 Drug sensitive Thiosangivamycin 3580213 Drug sensitive Bis(helenalinyl)glutarate 336831 Drug sensitive 6-(4-Chlorophenyl)sulfanylquinazoline-2,4-diamine 328131 Drug sensitive 2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive Antimycin A3 245869 Drug sensitive (2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive [(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug sensitive Antibiotic U 29135 24196291 Drug sensitive 7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide 23635154 Drug sensitive Drostanolone propionate 224004 Drug sensitive Kinetin riboside 20345 Drug resistant Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive 4-Chloro-5-(pyridin-2-ylthio)-3H-1,2-dithiole-3-thione 16766538 Drug sensitive 4H-1,3,2-Benzodioxastannin-4-one, 7-amino-2,2-diphenyl- 16683127 Drug sensitive Dihydroartemisinin (mixture of alpha and beta isomers) 16399850 Drug sensitive Triethyltin chloride 13820 Drug sensitive Astrazon Orange R 135747272 Drug sensitive (1R,2S,5S,8S,9S,17R,18R,21S,24R,26S,27S)-14-Chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone 134715214 Drug sensitive Melampodinin 11953936 Drug sensitive Unii-C616DV5Y11 117587576 Drug sensitive Cyanoaminopyranopyridine derivatives 11494577 Drug resistant Unii-9JU14BJ5QG 109374088 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive 15,16-Dihydrocuracin A 101683509 Drug sensitive (1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive Chimaphilin 101211 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive 1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug sensitive 1h-1,4,7-triazonine-1,4,7-triacetic acid, octahydro- - Drug sensitive 1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive 1-piperidinecarbodithioic acid, antimony complex - Drug sensitive 4'-deoxy-13',17-dinitro-3',4'-epoxy-vincaleukoblastine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive 9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive anthracen-9-one, 10-[(2-methoxyphenyl)methylene]- - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive benzonitrile, 2-amino-3,5-dinitro- (9ci) - Drug sensitive cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive geldanamycin, n,n'-dimethyl - Drug sensitive gold(1+), bis(trimethylphosphine)-, chloride - Drug sensitive iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive roridin a, 8-hydroxy-9b,10b-epoxy- - Drug sensitive uridine, 5-isobutyl-2'-deoxy- - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive 1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive 2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive antineoplastic-615538 - Drug sensitive antineoplastic-644916 - Drug sensitive bavachyaone - Drug sensitive geldanamycin analog - Drug sensitive isatin dr - Drug sensitive thiadiazines - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-590-5p	Nicotine 89594 Drug interaction    RC00006067 Formaldehyde 712 Drug interaction    RC00006061 Gemcitabine 60750 Drug interaction    RC00006066 5-Fluorouracil 3385 Drug interaction    RC00006064 Doxorubicin 31703 Drug interaction    RC00006065 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006063 Verapamil 2520 Drug interaction    RC00006062 Docetaxel 148124 Drug interaction    RC00006069 Ginsenoside Rh2 119307 Drug interaction    RC00006068 SIOP treatment protocol - Drug interaction    RC00006070

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-590-5p	Cisplatin 5702198       27757042 Paclitaxel 36314       27757042 Doxorubicin 31703       30111512

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-590-5p
Interactor2: IL1B

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR
Support Database	ViRBase

References:

PMID	30291142	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	A549 cells	Interactor2 expression	Downregulation
Description	Considering that miR-590-5p functions in different virus infection systems, the expression levels of IFN-beta, IFN-alpha, IL-1beta, IL6, and IL32 were measured in A549 cells infected with HSV-1, IAV, SeV, or VSV and those that remained uninfected. Similar inhibition was observed in the cells transfected with miR-590-5p mimics (Fig. 3, D-H).