Basic Information:

  VIRBase ID:  

HHID00092846

  Virus:  

Influenza A virus (A/Brisbane/10/2007(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4739:  MIMAT0019868          IFI44L:  NM_001375646     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4739	IFI44L
miRBase Accession/Entrez ID	MIMAT0019868	10964
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C1orf29//GS3686

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4739	rs1223789593 chr17:79707226    C/T rs1279007964 chr17:79707223    C/T rs1345189697 chr17:79707219    G/T rs1350222948 chr17:79707231    C/A rs1350222948 chr17:79707231    C/G rs1350222948 chr17:79707231    C/T rs1440530436 chr17:79707228    C/A rs1555819261 chr17:79707222    C/T rs73410309 chr17:79707227    G/A rs73410309 chr17:79707227    G/C rs73410309 chr17:79707227    G/T rs1313792237 chr17:79707236    C/T rs1416844919 chr17:79707238    C/T rs1555819263 chr17:79707233    C/T rs1555819268 chr17:79707239    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IFI44L	chr1:79108128(+) A-I      3'UTR chr1:79108193(+) A-I      3'UTR chr1:79108273(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IFI44L	chr1:79108193(+) A-I intron -    22327324 chr1:79089741(+) G-A intron -    22484847 chr1:79108067(+) T-A intron -    22484847 chr1:79108068(+) G-A intron -    22484847 chr1:79108069(+) C-A intron -    22484847 chr1:79108088(+) T-A intron -    22484847 chr1:79108091(+) G-A intron -    22484847 chr1:79108095(+) G-A intron -    22484847 chr1:79108098(+) C-A intron -    22484847 chr1:79108193(+) A-G intron -    22484847 chr1:79108266(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFI44L	chr1:79093891-79093892(+) m6A CDS//exon//intron       24981863 chr1:79108259-79108260(+) m6A 3'UTR//exon       24981863 chr1:79108269-79108270(+) m6A 3'UTR//exon       24981863 chr1:79108274-79108275(+) m6A 3'UTR//exon       24981863 chr1:79108289-79108290(+) m6A 3'UTR//exon       24981863 chr1:79108301-79108302(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4739	Exosome HeLa cells     24205503 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Urine     -
	IFI44L	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4739
Interactor2: IFI44L

Evidence Support:

Weak-Evidence	MiRNA microarray//RNA-Seq
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	30605755	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	B. Relationships between miRNAs and inversely correlated mRNAs involved in the host defense to virus. Green and red represent downregulated and upregulated genes, while triangles and circles represent miRNAs and target gene mRNAs, respectively.