Basic Information:

  VIRBase ID:  

HHID00092845

  Virus:  

Influenza A virus (A/Brisbane/10/2007(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4739:  MIMAT0019868          SOCS3:  NM_001378932     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4739	SOCS3
miRBase Accession/Entrez ID	MIMAT0019868	9021
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ATOD4//CIS3//Cish3//SOCS-3//SSI-3//SSI3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4739	rs1223789593 chr17:79707226    C/T rs1279007964 chr17:79707223    C/T rs1345189697 chr17:79707219    G/T rs1350222948 chr17:79707231    C/A rs1350222948 chr17:79707231    C/G rs1350222948 chr17:79707231    C/T rs1440530436 chr17:79707228    C/A rs1555819261 chr17:79707222    C/T rs73410309 chr17:79707227    G/A rs73410309 chr17:79707227    G/C rs73410309 chr17:79707227    G/T rs1313792237 chr17:79707236    C/T rs1416844919 chr17:79707238    C/T rs1555819263 chr17:79707233    C/T rs1555819268 chr17:79707239    T/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SOCS3	chr17:76352903-76352904(-) m6A 3'UTR       24981863//27773535 chr17:76352939-76352940(-) m6A 3'UTR       24284625//24981863//27773535 chr17:76352966-76352967(-) m6A 3'UTR       24284625//24981863//27773535 chr17:76353177-76353178(-) m6A 3'UTR       24284625 chr17:76353229-76353230(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828 chr17:76353316-76353317(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828 chr17:76353479-76353480(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535 chr17:76353537-76353538(-) m6A 3'UTR       24284625//24209618//25456834//27773535 chr17:76353590-76353591(-) m6A 3'UTR       24284625//24209618//25456834//27773535 chr17:76353670-76353671(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535 chr17:76353702-76353703(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535 chr17:76353874-76353875(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828 chr17:76353887-76353888(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828 chr17:76353920-76353921(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828 chr17:76354069-76354070(-) Am 3'UTR       - chr17:76354095-76354096(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:76354122-76354123(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:76354135-76354136(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:76354154-76354155(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:76354164-76354165(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:76354182-76354183(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:76354189-76354190(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:76354325-76354326(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:76354370-76354371(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:76354520-76354521(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:76354571-76354572(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960 chr17:76354590-76354591(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960 chr17:76354750-76354751(-) m6A CDS       24284625//24209618//24981863//22575960 chr17:76354901-76354902(-) m6A CDS       24284625//24981863//22575960 chr17:76354908-76354909(-) m6A CDS       24284625//24981863//27371828//22575960 chr17:76354920-76354921(-) m6A CDS       24284625//24981863//27371828//22575960 chr17:76354952-76354953(-) m6A CDS       24284625//24981863//27371828//22575960 chr17:76355006-76355007(-) m6A CDS       24284625//24981863//27371828//22575960 chr17:76355106-76355107(-) m6A CDS       24284625//27371828 chr17:76355126-76355127(-) m6A CDS       24284625//27371828 chr17:76355834-76355835(-) m6A 5'UTR//intron       27371828 chr17:76355847-76355848(-) m6A 5'UTR//intron       27371828 chr17:76355877-76355878(-) m6A 5'UTR//intron       27371828 chr17:76356144-76356145(-) m6A 5'UTR       24209618

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4739	Exosome HeLa cells     24205503 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Urine     -
	SOCS3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4739
Interactor2: SOCS3

Evidence Support:

Weak-Evidence	MiRNA microarray//RNA-Seq
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	30605755	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	A. Relationships between miRNAs and inversely correlated mRNAs involved in the influenza A pathway.