Basic Information:

  VIRBase ID:  

HHID00092840

  Virus:  

Influenza A virus (A/Brisbane/10/2007(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4739:  MIMAT0019868          CIITA:  NR_104444     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4739	CIITA
miRBase Accession/Entrez ID	MIMAT0019868	4261
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C2TA//CIITAIV//MHC2TA//NLRA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4739	rs1223789593 chr17:79707226    C/T rs1279007964 chr17:79707223    C/T rs1345189697 chr17:79707219    G/T rs1350222948 chr17:79707231    C/A rs1350222948 chr17:79707231    C/G rs1350222948 chr17:79707231    C/T rs1440530436 chr17:79707228    C/A rs1555819261 chr17:79707222    C/T rs73410309 chr17:79707227    G/A rs73410309 chr17:79707227    G/C rs73410309 chr17:79707227    G/T rs1313792237 chr17:79707236    C/T rs1416844919 chr17:79707238    C/T rs1555819263 chr17:79707233    C/T rs1555819268 chr17:79707239    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CIITA	chr16:11013768(+) A-I      intronic chr16:11013744(+) A-I      intronic chr16:11013737(+) A-I      intronic chr16:11013734(+) A-I      intronic chr16:10984273(+) A-I      intronic chr16:11013776(+) A-I      intronic chr16:11022225(+) A-I      3'UTR chr16:11020572(+) A-I      3'UTR chr16:10986777(+) A-I      intronic chr16:10987501(+) A-I      intronic chr16:10987513(+) A-I      intronic chr16:10987961(+) A-I      intronic chr16:11006218(+) A-I      intronic chr16:11006223(+) A-I      intronic chr16:11007191(+) A-I      intronic chr16:11007308(+) A-I      intronic chr16:10986589(+) A-I      intronic chr16:10984353(+) A-I      intronic chr16:10983597(+) A-I      intronic chr16:10983556(+) A-I      intronic chr16:10983550(+) A-I      intronic chr16:10983502(+) A-I      intronic chr16:10983477(+) A-I      intronic chr16:10978437(+) A-I      intronic chr16:10978429(+) A-I      intronic chr16:10978427(+) A-I      intronic chr16:10976373(+) A-I      intronic chr16:10984333(+) A-I      intronic chr16:11007579(+) A-I      intronic chr16:10984283(+) A-I      intronic chr16:10984205(+) A-I      intronic chr16:10983598(+) A-I      intronic chr16:10986637(+) A-I      intronic chr16:10986612(+) A-I      intronic chr16:10986776(+) A-I      intronic chr16:11007370(+) A-I      intronic chr16:11007418(+) A-I      intronic chr16:11007613(+) A-I      intronic chr16:11020524(+) A-I      3'UTR chr16:11020497(+) A-I      3'UTR chr16:11020510(+) A-I      3'UTR chr16:11020515(+) A-I      3'UTR chr16:11020421(+) A-I      3'UTR chr16:11020523(+) A-I      3'UTR chr16:11020563(+) A-I      3'UTR chr16:11018352(+) A-I      3'UTR chr16:11019215(+) A-I      3'UTR chr16:11022383(+) A-I      3'UTR chr16:11022345(+) A-I      3'UTR chr16:11022215(+) A-I      3'UTR chr16:11018342(+) A-I      3'UTR chr16:11019402(+) A-I      3'UTR chr16:11022206(+) A-I      3'UTR chr16:11020589(+) A-I      3'UTR chr16:11007301(+) A-I      intronic chr16:11007542(+) A-I      intronic chr16:11007271(+) A-I      intronic chr16:10999440(+) A-I      intronic chr16:10987898(+) A-I      intronic chr16:11007609(+) A-I      intronic chr16:11007624(+) A-I      intronic chr16:11007608(+) A-I      intronic chr16:11019216(+) A-I      3'UTR chr16:11018367(+) A-I      3'UTR chr16:11020498(+) A-I      3'UTR chr16:11019264(+) A-I      3'UTR chr16:11018118(+) A-I      3'UTR chr16:11022409(+) A-I      3'UTR chr16:10984244(+) A-I      intronic chr16:10978296(+) A-I      intronic chr16:10989589(+) A-I      NonSyn:Asp->Gly chr16:11003731(+) A-I      intronic chr16:10983408(+) A-I      intronic chr16:11007272(+) A-I      intronic chr16:11013491(+) A-I      intronic chr16:10983470(+) A-I      intronic chr16:11007311(+) A-I      intronic chr16:10999363(+) A-I      intronic chr16:11007541(+) A-I      intronic chr16:11007433(+) A-I      intronic chr16:11007687(+) A-I      intronic chr16:11007568(+) A-I      intronic chr16:11008987(+) A-I      intronic chr16:11007378(+) A-I      intronic chr16:11008982(+) A-I      intronic chr16:10999862(+) A-I      intronic chr16:11007677(+) A-I      intronic chr16:10999362(+) A-I      intronic chr16:11007651(+) A-I      intronic chr16:10986636(+) A-I      intronic chr16:11007235(+) A-I      intronic chr16:11007763(+) A-I      intronic chr16:10975112(+) A-I      intronic chr16:10986580(+) A-I      intronic chr16:10984364(+) A-I      intronic chr16:11013492(+) A-I      intronic chr16:10987944(+) A-I      intronic chr16:10981590(+) A-I      intronic chr16:11007233(+) A-I      intronic chr16:11007236(+) A-I      intronic chr16:10986588(+) A-I      intronic chr16:10978295(+) A-I      intronic chr16:10975093(+) A-I      intronic chr16:10983396(+) A-I      intronic chr16:10986660(+) A-I      intronic chr16:10981446(+) A-I      intronic chr16:11008972(+) A-I      intronic chr16:11013729(+) A-I      intronic chr16:11013732(+) A-I      intronic chr16:11013743(+) A-I      intronic chr16:11013772(+) A-I      intronic chr16:10984287(+) A-I      intronic chr16:11013716(+) A-I      intronic chr16:11013733(+) A-I      intronic chr16:11013764(+) A-I      intronic chr16:11013728(+) A-I      intronic chr16:11013526(+) A-I      intronic chr16:11007753(+) A-I      intronic chr16:10976663(+) A-I      intronic chr16:11013527(+) A-I      intronic chr16:11013773(+) A-I      intronic chr16:11013612(+) A-I      intronic chr16:11007519(+) A-I      intronic chr16:11013634(+) A-I      intronic chr16:11013506(+) A-I      intronic chr16:11013709(+) A-I      intronic chr16:11013517(+) A-I      intronic chr16:11020578(+) A-I      3'UTR chr16:11020581(+) A-I      3'UTR chr16:11018312(+) A-I      3'UTR chr16:11022263(+) A-I      3'UTR chr16:11018279(+) A-I      3'UTR chr16:11018324(+) A-I      3'UTR chr16:11019263(+) A-I      3'UTR chr16:11019419(+) A-I      3'UTR chr16:11022250(+) A-I      3'UTR chr16:11022331(+) A-I      3'UTR chr16:11018220(+) A-I      3'UTR chr16:11020583(+) A-I      3'UTR chr16:11020478(+) A-I      3'UTR chr16:11018290(+) A-I      3'UTR chr16:11020434(+) A-I      3'UTR chr16:11020459(+) A-I      3'UTR chr16:11022214(+) A-I      3'UTR chr16:11020501(+) A-I      3'UTR chr16:11018230(+) A-I      3'UTR chr16:11020462(+) A-I      3'UTR chr16:11022249(+) A-I      3'UTR chr16:11022376(+) A-I      3'UTR chr16:11022328(+) A-I      3'UTR chr16:11018299(+) A-I      3'UTR chr16:11018232(+) A-I      3'UTR chr16:11019276(+) A-I      3'UTR chr16:11018191(+) A-I      3'UTR chr16:11020598(+) A-I      3'UTR chr16:11020502(+) A-I      3'UTR chr16:11018256(+) A-I      3'UTR chr16:11018240(+) A-I      3'UTR chr16:11018273(+) A-I      3'UTR chr16:11018310(+) A-I      3'UTR chr16:11022275(+) A-I      3'UTR chr16:11022245(+) A-I      3'UTR chr16:11022246(+) A-I      3'UTR chr16:11020595(+) A-I      3'UTR chr16:11018270(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CIITA	chr16:10989589(+) A-I exon CDS    15342557 chr16:10995933(+) A-I exon CDS    15342557 chr16:11002927(+) A-I exon CDS    15342557 chr16:11018118(+) A-I exon 3'UTR    15342557 chr16:11018220(+) A-I exon 3'UTR    15342557 chr16:11018230(+) A-I exon 3'UTR    15342557 chr16:11018232(+) A-I exon 3'UTR    15342557 chr16:11018240(+) A-I exon 3'UTR    15342557 chr16:11018270(+) A-I exon 3'UTR    15342557   //15258596 chr16:11018290(+) A-I exon 3'UTR    15342557   //15258596 chr16:11018299(+) A-I exon 3'UTR    15342557   //15258596 chr16:11018310(+) A-I exon 3'UTR    15342557   //15258596 chr16:11018324(+) A-I exon 3'UTR    15342557   //15258596 chr16:11013716(+) A-I intron -    22327324 chr16:11013732(+) A-I intron -    22327324 chr16:11013733(+) A-I intron -    22327324 chr16:11013716(+) A-G intron -    22484847 chr16:11013728(+) A-G intron -    22484847 chr16:11013729(+) A-G intron -    22484847 chr16:11013732(+) A-G intron -    22484847 chr16:11013733(+) A-G intron -    22484847 chr16:11013743(+) A-G intron -    22484847 chr16:11013764(+) A-G intron -    22484847 chr16:10999440(+) A-G intron -    22484847 chr16:11007608(+) A-G intron -    22484847 chr16:11007677(+) A-G intron -    22484847 chr16:11007687(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CIITA	chr16:10989249-10989250(+) m6A CDS//exon       - chr16:10989537-10989538(+) m6A CDS//exon       - chr16:10989596-10989597(+) m6A CDS//exon       - chr16:10992530-10992531(+) m6A CDS//exon       - chr16:10992535-10992536(+) m6A CDS//exon       - chr16:10992553-10992554(+) m6A CDS//exon       - chr16:10992580-10992581(+) m6A CDS//exon       - chr16:10992791-10992792(+) m6A CDS//exon       - chr16:10995934-10995935(+) m6A 3'UTR//CDS//exon//intron       - chr16:10996025-10996026(+) m6A 3'UTR//CDS//exon//intron       - chr16:10996560-10996561(+) m6A 3'UTR//CDS//exon       - chr16:10996627-10996628(+) m6A CDS//exon       - chr16:10997659-10997660(+) m6A CDS//exon       - chr16:10997720-10997721(+) m6A CDS//exon       - chr16:10997743-10997744(+) m6A CDS//exon       - chr16:11000388-11000389(+) m6A CDS//exon//intron       - chr16:11000491-11000492(+) m6A CDS//exon//intron       22575960 chr16:11000505-11000506(+) m6A CDS//exon//intron       22575960 chr16:11000585-11000586(+) m6A CDS//exon//intron       22575960 chr16:11000718-11000719(+) m6A CDS//exon//intron       - chr16:11001123-11001124(+) m6A CDS//exon//intron       - chr16:11001147-11001148(+) m6A CDS//exon//intron       - chr16:11001265-11001266(+) m6A CDS//exon//intron       - chr16:11001358-11001359(+) m6A CDS//exon//intron       22575960 chr16:11001381-11001382(+) m6A CDS//exon//intron       22575960 chr16:11001407-11001408(+) m6A CDS//exon//intron       22575960 chr16:11001537-11001538(+) m6A CDS//exon//intron       22575960 chr16:11001696-11001697(+) m6A CDS//exon//intron       22575960 chr16:11001746-11001747(+) m6A CDS//exon//intron       22575960 chr16:11001921-11001922(+) m6A CDS//exon//intron       22575960 chr16:11001933-11001934(+) m6A CDS//exon//intron       22575960 chr16:11001982-11001983(+) m6A CDS//exon//intron       - chr16:11002031-11002032(+) m6A CDS//exon//intron       - chr16:11002275-11002276(+) m6A 3'UTR//exon//intron       - chr16:11002368-11002369(+) m6A 3'UTR//exon//intron       - chr16:11002940-11002941(+) m6A CDS//exon//intron       - chr16:11004064-11004065(+) m6A CDS//exon       - chr16:11004094-11004095(+) m6A CDS//exon       - chr16:11004104-11004105(+) m6A 3'UTR//CDS//exon       - chr16:11009462-11009463(+) m6A 3'UTR//CDS//exon       - chr16:11017882-11017883(+) m6A 3'UTR//exon       - chr16:11017905-11017906(+) m6A 3'UTR//exon       - chr16:11018001-11018002(+) m6A 3'UTR//exon       - chr16:11018010-11018011(+) m6A 3'UTR//exon       - chr16:11018113-11018114(+) m6A 3'UTR//exon       - chr16:11018276-11018277(+) m6A 3'UTR//exon       - chr16:11018311-11018312(+) m6A 3'UTR//exon       - chr16:11018426-11018427(+) m6A 3'UTR//exon       - chr16:11018459-11018460(+) m6A 3'UTR//exon       - chr16:11018541-11018542(+) m6A 3'UTR//exon       22575960 chr16:11018613-11018614(+) m6A 3'UTR//exon       22575960 chr16:11018625-11018626(+) m6A 3'UTR//exon       22575960 chr16:11018650-11018651(+) m6A 3'UTR//exon       22575960 chr16:11022806-11022807(+) m6A 3'UTR//intron       27773535//22608085 chr16:11023011-11023012(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:11023029-11023030(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:11023045-11023046(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:11023183-11023184(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:11023204-11023205(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:11023372-11023373(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27371828//22608085 chr16:11023378-11023379(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27371828//22608085 chr16:11023482-11023483(+) m6A 3'UTR//intron       27371828 chr16:11023488-11023489(+) m6A 3'UTR//intron       27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4739	Exosome HeLa cells     24205503 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Urine     -
	CIITA	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleolus K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4739
Interactor2: CIITA

Evidence Support:

Weak-Evidence	MiRNA microarray//RNA-Seq
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	30605755	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	A. Relationships between miRNAs and inversely correlated mRNAs involved in the influenza A pathway.