Basic Information:

  VIRBase ID:  

HHID00092832

  Virus:  

Influenza A virus (A/Brisbane/10/2007(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4530:  MIMAT0019069          PIK3CG:  NM_002649     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4530	PIK3CG
miRBase Accession/Entrez ID	MIMAT0019069	5294
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	p110gamma//p120-PI3K//PI3CG//PI3K//PI3Kgamma//PIK3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4530	rs1158939434 chr19:39409633    C/G rs1302370391 chr19:39409637    T/C rs1405299984 chr19:39409645    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PIK3CG	chr7:106521177(+) A-I      intronic chr7:106521175(+) A-I      intronic chr7:106522298(+) A-I      intronic chr7:106522108(+) A-I      intronic chr7:106522037(+) A-I      intronic chr7:106521227(+) A-I      intronic chr7:106517396(+) A-I      intronic chr7:106517442(+) A-I      intronic chr7:106517457(+) A-I      intronic chr7:106521250(+) A-I      intronic chr7:106522106(+) A-I      intronic chr7:106521257(+) A-I      intronic chr7:106522215(+) A-I      intronic chr7:106521160(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PIK3CG	chr7:106516354(+) G-T intron -    22484847 chr7:106521250(+) A-G intron -    22484847 chr7:106521257(+) A-G intron -    22484847 chr7:106521326(+) A-G intron -    22484847 chr7:106522106(+) A-G intron -    22484847 chr7:106522215(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIK3CG	chr7:106508246-106508247(+) m6A CDS//intron       - chr7:106508262-106508263(+) m6A CDS//intron       - chr7:106508281-106508282(+) m6A CDS//intron       - chr7:106508357-106508358(+) m6A CDS//intron       - chr7:106508364-106508365(+) m6A CDS//intron       - chr7:106508806-106508807(+) m6A CDS//intron       - chr7:106508871-106508872(+) m6A CDS//intron       25456834 chr7:106508928-106508929(+) m6A CDS//intron       25456834 chr7:106508940-106508941(+) m6A CDS//intron       25456834 chr7:106509039-106509040(+) m6A CDS//intron       - chr7:106509072-106509073(+) m6A CDS//intron       - chr7:106509132-106509133(+) m6A CDS//intron       - chr7:106509162-106509163(+) m6A CDS//intron       - chr7:106509483-106509484(+) m6A CDS//intron       - chr7:106509508-106509509(+) m6A CDS//intron       - chr7:106509531-106509532(+) m6A CDS//intron       - chr7:106509540-106509541(+) m6A CDS//intron       - chr7:106509567-106509568(+) m6A CDS//intron       - chr7:106509627-106509628(+) m6A CDS//intron       - chr7:106509717-106509718(+) m6A CDS//intron       - chr7:106509802-106509803(+) m6A CDS//intron       - chr7:106509824-106509825(+) m6A CDS//intron       - chr7:106509900-106509901(+) m6A CDS//intron       - chr7:106509946-106509947(+) m6A CDS//intron       - chr7:106545807-106545808(+) m6A CDS       - chr7:106545819-106545820(+) m6A CDS       - chr7:106545853-106545854(+) m6A 3'UTR       - chr7:106545897-106545898(+) m6A 3'UTR       - chr7:106545919-106545920(+) m6A 3'UTR       - chr7:106545967-106545968(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4530	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	PIK3CG	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4530
Interactor2: PIK3CG

Evidence Support:

Weak-Evidence	MiRNA microarray//RNA-Seq
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	30605755	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	A. Relationships between miRNAs and inversely correlated mRNAs involved in the influenza A pathway.