Basic Information:

  VIRBase ID:  

HHID00092830

  Virus:  

Influenza A virus (A/Brisbane/10/2007(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4530:  MIMAT0019069          ICAM1:  NM_000201     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4530	ICAM1
miRBase Accession/Entrez ID	MIMAT0019069	3383
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BB2//CD54//P3.58

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4530	rs1158939434 chr19:39409633    C/G rs1302370391 chr19:39409637    T/C rs1405299984 chr19:39409645    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ICAM1	chr19:10393726(+) A-I      intronic chr19:10389461(+) A-I      intronic chr19:10393639(+) A-I      intronic chr19:10382746(+) A-I      intronic chr19:10382747(+) A-I      intronic chr19:10388713(+) A-I      intronic chr19:10389964(+) A-I      intronic chr19:10391124(+) A-I      intronic chr19:10391320(+) A-I      intronic chr19:10391326(+) A-I      intronic chr19:10391333(+) A-I      intronic chr19:10392546(+) A-I      intronic chr19:10392566(+) A-I      intronic chr19:10388679(+) A-I      intronic chr19:10392567(+) A-I      intronic chr19:10393600(+) A-I      intronic chr19:10393617(+) A-I      intronic chr19:10389407(+) A-I      intronic chr19:10382911(+) A-I      intronic chr19:10389942(+) A-I      intronic chr19:10390523(+) A-I      intronic chr19:10392873(+) A-I      intronic chr19:10393041(+) A-I      intronic chr19:10384530(+) A-I      intronic chr19:10393053(+) A-I      intronic chr19:10393065(+) A-I      intronic chr19:10393104(+) A-I      intronic chr19:10393105(+) A-I      intronic chr19:10393133(+) A-I      intronic chr19:10393503(+) A-I      intronic chr19:10393528(+) A-I      intronic chr19:10393536(+) A-I      intronic chr19:10393558(+) A-I      intronic chr19:10393582(+) A-I      intronic chr19:10393644(+) A-I      intronic chr19:10393674(+) A-I      intronic chr19:10393734(+) A-I      intronic chr19:10393806(+) A-I      intronic chr19:10393829(+) A-I      intronic chr19:10389398(+) A-I      intronic chr19:10389321(+) A-I      intronic chr19:10388788(+) A-I      intronic chr19:10388733(+) A-I      intronic chr19:10388717(+) A-I      intronic chr19:10388716(+) A-I      intronic chr19:10388697(+) A-I      intronic chr19:10388641(+) A-I      intronic chr19:10388619(+) A-I      intronic chr19:10388618(+) A-I      intronic chr19:10391059(+) A-I      intronic chr19:10386015(+) A-I      intronic chr19:10388422(+) A-I      intronic chr19:10390460(+) A-I      intronic chr19:10390434(+) A-I      intronic chr19:10390395(+) A-I      intronic chr19:10390389(+) A-I      intronic chr19:10390357(+) A-I      intronic chr19:10390346(+) A-I      intronic chr19:10390277(+) A-I      intronic chr19:10390104(+) A-I      intronic chr19:10386298(+) A-I      intronic chr19:10387153(+) A-I      intronic chr19:10387170(+) A-I      intronic chr19:10387171(+) A-I      intronic chr19:10387392(+) A-I      intronic chr19:10387393(+) A-I      intronic chr19:10387433(+) A-I      intronic chr19:10387547(+) A-I      intronic chr19:10387553(+) A-I      intronic chr19:10387562(+) A-I      intronic chr19:10388361(+) A-I      intronic chr19:10390056(+) A-I      intronic chr19:10389987(+) A-I      intronic chr19:10389965(+) A-I      intronic chr19:10389470(+) A-I      intronic chr19:10389418(+) A-I      intronic chr19:10388356(+) A-I      intronic chr19:10388347(+) A-I      intronic chr19:10388303(+) A-I      intronic chr19:10388293(+) A-I      intronic chr19:10388861(+) A-I      intronic chr19:10385987(+) A-I      intronic chr19:10387996(+) A-I      intronic chr19:10388094(+) A-I      intronic chr19:10388233(+) A-I      intronic chr19:10385958(+) A-I      intronic chr19:10385937(+) A-I      intronic chr19:10385226(+) A-I      intronic chr19:10385091(+) A-I      intronic chr19:10385090(+) A-I      intronic chr19:10384685(+) A-I      intronic chr19:10384531(+) A-I      intronic chr19:10384680(+) A-I      intronic chr19:10384678(+) A-I      intronic chr19:10384674(+) A-I      intronic chr19:10384532(+) A-I      intronic chr19:10391434(+) A-I      intronic chr19:10391093(+) A-I      intronic chr19:10391113(+) A-I      intronic chr19:10391143(+) A-I      intronic chr19:10391171(+) A-I      intronic chr19:10391301(+) A-I      intronic chr19:10391429(+) A-I      intronic chr19:10386026(+) A-I      intronic chr19:10391479(+) A-I      intronic chr19:10392470(+) A-I      intronic chr19:10392543(+) A-I      intronic chr19:10392562(+) A-I      intronic chr19:10392787(+) A-I      intronic chr19:10388267(+) A-I      intronic chr19:10388268(+) A-I      intronic chr19:10388290(+) A-I      intronic chr19:10392813(+) A-I      intronic chr19:10382910(+) A-I      intronic chr19:10392843(+) A-I      intronic chr19:10392861(+) A-I      intronic chr19:10392869(+) A-I      intronic chr19:10392870(+) A-I      intronic chr19:10391689(+) A-I      intronic chr19:10390486(+) A-I      intronic chr19:10393724(+) A-I      intronic chr19:10386295(+) A-I      intronic chr19:10391346(+) A-I      intronic chr19:10393512(+) A-I      intronic chr19:10386646(+) A-I      intronic chr19:10393765(+) A-I      intronic chr19:10386591(+) A-I      intronic chr19:10393801(+) A-I      intronic chr19:10388632(+) A-I      intronic chr19:10393733(+) A-I      intronic chr19:10391984(+) A-I      intronic chr19:10390068(+) A-I      intronic chr19:10386104(+) A-I      intronic chr19:10385171(+) A-I      intronic chr19:10390121(+) A-I      intronic chr19:10392011(+) A-I      intronic chr19:10386160(+) A-I      intronic chr19:10382880(+) A-I      intronic chr19:10390412(+) A-I      intronic chr19:10387879(+) A-I      intronic chr19:10390365(+) A-I      intronic chr19:10391315(+) A-I      intronic chr19:10391425(+) A-I      intronic chr19:10391323(+) A-I      intronic chr19:10393730(+) A-I      intronic chr19:10393089(+) A-I      intronic chr19:10388329(+) A-I      intronic chr19:10391874(+) A-I      intronic chr19:10388766(+) A-I      intronic chr19:10387471(+) A-I      intronic chr19:10392883(+) A-I      intronic chr19:10386098(+) A-I      intronic chr19:10384280(+) A-I      intronic chr19:10393621(+) A-I      intronic chr19:10393727(+) A-I      intronic chr19:10388220(+) A-I      intronic chr19:10386289(+) A-I      intronic chr19:10393024(+) A-I      intronic chr19:10382720(+) A-I      intronic chr19:10387957(+) A-I      intronic chr19:10389318(+) A-I      intronic chr19:10385922(+) A-I      intronic chr19:10387887(+) A-I      intronic chr19:10393166(+) A-I      intronic chr19:10393330(+) A-I      intronic chr19:10388648(+) A-I      intronic chr19:10384570(+) A-I      intronic chr19:10384596(+) A-I      intronic chr19:10391339(+) A-I      intronic chr19:10387918(+) A-I      intronic chr19:10390074(+) A-I      intronic chr19:10390422(+) A-I      intronic chr19:10386159(+) A-I      intronic chr19:10388238(+) A-I      intronic chr19:10391411(+) A-I      intronic chr19:10382693(+) A-I      intronic chr19:10393614(+) A-I      intronic chr19:10392793(+) A-I      intronic chr19:10393578(+) A-I      intronic chr19:10388696(+) A-I      intronic chr19:10393760(+) A-I      intronic chr19:10382752(+) A-I      intronic chr19:10385084(+) A-I      intronic chr19:10383891(+) A-I      intronic chr19:10388828(+) A-I      intronic chr19:10388660(+) A-I      intronic chr19:10386022(+) A-I      intronic chr19:10388752(+) A-I      intronic chr19:10388715(+) A-I      intronic chr19:10388793(+) A-I      intronic chr19:10383472(+) A-I      intronic chr19:10393812(+) A-I      intronic chr19:10393773(+) A-I      intronic chr19:10393464(+) A-I      intronic chr19:10393474(+) A-I      intronic chr19:10390324(+) A-I      intronic chr19:10382713(+) A-I      intronic chr19:10393513(+) A-I      intronic chr19:10390038(+) A-I      intronic chr19:10392821(+) A-I      intronic chr19:10389347(+) A-I      intronic chr19:10382907(+) A-I      intronic chr19:10393568(+) A-I      intronic chr19:10385211(+) A-I      intronic chr19:10392454(+) A-I      intronic chr19:10383485(+) A-I      intronic chr19:10386053(+) A-I      intronic chr19:10386658(+) A-I      intronic chr19:10391473(+) A-I      intronic chr19:10387530(+) A-I      intronic chr19:10391385(+) A-I      intronic chr19:10388728(+) A-I      intronic chr19:10390005(+) A-I      intronic chr19:10393434(+) A-I      intronic chr19:10392015(+) A-I      intronic chr19:10391679(+) A-I      intronic chr19:10391375(+) A-I      intronic chr19:10382846(+) A-I      intronic chr19:10390344(+) A-I      intronic chr19:10386288(+) A-I      intronic chr19:10389492(+) A-I      intronic chr19:10393759(+) A-I      intronic chr19:10389958(+) A-I      intronic chr19:10383381(+) A-I      intronic chr19:10393483(+) A-I      intronic chr19:10390421(+) A-I      intronic chr19:10382881(+) A-I      intronic chr19:10389357(+) A-I      intronic chr19:10391363(+) A-I      intronic chr19:10392993(+) A-I      intronic chr19:10388689(+) A-I      intronic chr19:10390498(+) A-I      intronic chr19:10387531(+) A-I      intronic chr19:10392692(+) A-I      intronic chr19:10393638(+) A-I      intronic chr19:10388719(+) A-I      intronic chr19:10386334(+) A-I      intronic chr19:10382698(+) A-I      intronic chr19:10391282(+) A-I      intronic chr19:10390299(+) A-I      intronic chr19:10387956(+) A-I      intronic chr19:10386043(+) A-I      intronic chr19:10393090(+) A-I      intronic chr19:10392506(+) A-I      intronic chr19:10388746(+) A-I      intronic chr19:10389992(+) A-I      intronic chr19:10388129(+) A-I      intronic chr19:10391129(+) A-I      intronic chr19:10390360(+) A-I      intronic chr19:10383341(+) A-I      intronic chr19:10388720(+) A-I      intronic chr19:10390188(+) A-I      intronic chr19:10383419(+) A-I      intronic chr19:10391136(+) A-I      intronic chr19:10393569(+) A-I      intronic chr19:10385152(+) A-I      intronic chr19:10391111(+) A-I      intronic chr19:10386092(+) A-I      intronic chr19:10383473(+) A-I      intronic chr19:10390470(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ICAM1	chr19:10388632(+) A-I intron -    22327324 chr19:10389992(+) A-I intron -    22327324 chr19:10390324(+) A-I intron -    22327324 chr19:10390325(+) A-I intron -    22327324 chr19:10390365(+) A-I intron -    22327324 chr19:10390480(+) A-I intron -    22327324 chr19:10391111(+) A-I intron -    22327324 chr19:10393569(+) A-I intron -    22327324 chr19:10393760(+) A-I intron -    22327324 chr19:10384570(+) A-G intron -    22484847 chr19:10385211(+) A-G intron -    22484847 chr19:10386052(+) A-G intron -    22484847 chr19:10386053(+) A-G intron -    22484847 chr19:10386062(+) A-G intron -    22484847 chr19:10386104(+) A-G intron -    22484847 chr19:10386289(+) A-G intron -    22484847 chr19:10387471(+) A-G intron -    22484847 chr19:10387514(+) A-G intron -    22484847 chr19:10387524(+) A-G intron -    22484847 chr19:10387530(+) A-G intron -    22484847 chr19:10388264(+) A-G intron -    22484847 chr19:10388616(+) A-G intron -    22484847 chr19:10388632(+) A-G intron -    22484847 chr19:10388665(+) A-G intron -    22484847 chr19:10388696(+) A-G intron -    22484847 chr19:10388710(+) A-G intron -    22484847 chr19:10389318(+) A-G intron -    22484847 chr19:10389992(+) A-G intron -    22484847 chr19:10390038(+) A-G intron -    22484847 chr19:10390324(+) A-G intron -    22484847 chr19:10390325(+) A-G intron -    22484847 chr19:10390360(+) A-G intron -    22484847 chr19:10390365(+) A-G intron -    22484847 chr19:10390422(+) A-G intron -    22484847 chr19:10390466(+) A-G intron -    22484847 chr19:10390470(+) A-G intron -    22484847 chr19:10390480(+) A-G intron -    22484847 chr19:10391111(+) A-G intron -    22484847 chr19:10391315(+) A-G intron -    22484847 chr19:10391363(+) A-G intron -    22484847 chr19:10391375(+) A-G intron -    22484847 chr19:10392792(+) A-G intron -    22484847 chr19:10392793(+) A-G intron -    22484847 chr19:10392821(+) A-G intron -    22484847 chr19:10393727(+) A-G intron -    22484847 chr19:10393729(+) A-G intron -    22484847 chr19:10393730(+) A-G intron -    22484847 chr19:10393759(+) A-G intron -    22484847 chr19:10393760(+) A-G intron -    22484847 chr19:10393769(+) A-G intron -    22484847 chr19:10393773(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ICAM1	chr19:10385457-10385458(+) m6A CDS//intron       24284625 chr19:10385556-10385557(+) m6A CDS//intron       24284625//27773535 chr19:10385593-10385594(+) m6A CDS//intron       24284625//27773535 chr19:10385612-10385613(+) m6A CDS//intron       24284625//27773535 chr19:10385656-10385657(+) m6A CDS//intron       24284625//24981863//27773535 chr19:10385685-10385686(+) m6A CDS//intron       24284625//24981863//27773535 chr19:10394213-10394214(+) m6A CDS//exon//intron       - chr19:10394391-10394392(+) m6A CDS//exon//intron       24284625//27773535 chr19:10394396-10394397(+) m6A CDS//exon//intron       24284625//27773535 chr19:10394429-10394430(+) m6A CDS//exon//intron       27773535 chr19:10394455-10394456(+) m6A CDS//exon//intron       - chr19:10394957-10394958(+) m6A CDS       27773535 chr19:10394971-10394972(+) m6A CDS       27773535 chr19:10394980-10394981(+) m6A CDS       27773535 chr19:10395243-10395244(+) m6A CDS       27773535 chr19:10395306-10395307(+) m6A CDS       27773535 chr19:10395311-10395312(+) m6A CDS       27773535 chr19:10395494-10395495(+) m6A CDS       27773535 chr19:10395523-10395524(+) m6A CDS       24284625 chr19:10395548-10395549(+) m6A CDS       24284625//25456834//27773535 chr19:10395902-10395903(+) m6A CDS       24284625//24209618//25456834//24981863//27773535 chr19:10395924-10395925(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960 chr19:10395935-10395936(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960 chr19:10395940-10395941(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960 chr19:10395963-10395964(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960 chr19:10395975-10395976(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960 chr19:10396027-10396028(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960 chr19:10396039-10396040(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960 chr19:10396084-10396085(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960 chr19:10396146-10396147(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960 chr19:10396204-10396205(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960 chr19:10396211-10396212(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960 chr19:10396266-10396267(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr19:10396285-10396286(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr19:10396308-10396309(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr19:10396343-10396344(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960 chr19:10396370-10396371(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960 chr19:10396387-10396388(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960 chr19:10396523-10396524(+) m6A 3'UTR       24284625//27773535 chr19:10396642-10396643(+) m6A 3'UTR       24284625//24981863//27773535 chr19:10396712-10396713(+) m6A 3'UTR       24284625//24981863//27773535 chr19:10396775-10396776(+) m6A 3'UTR       24284625//24981863//27773535 chr19:10396855-10396856(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4530	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ICAM1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4530
Interactor2: ICAM1

Evidence Support:

Weak-Evidence	MiRNA microarray//RNA-Seq
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	30605755	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	A. Relationships between miRNAs and inversely correlated mRNAs involved in the influenza A pathway.