Basic Information:

  VIRBase ID:  

HHID00092799

  Virus:  

Influenza A virus (A/Brisbane/10/2007(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-762:  MIMAT0010313          CIITA:  NR_104444     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-762	CIITA
miRBase Accession/Entrez ID	MIMAT0010313	4261
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C2TA//CIITAIV//MHC2TA//NLRA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-762	rs1379218716 chr16:30893951    G/A rs1401867087 chr16:30893964    G/A rs1406702631 chr16:30893966    G/A rs1407433182 chr16:30893961    C/G rs374396561 chr16:30893962    C/T rs751832217 chr16:30893968    C/G rs752364708 chr16:30893961    CCGGGGCCGAGCCCGCGG/C rs755205907 chr16:30893971    G/T rs758841312 chr16:30893963    G/A rs758841312 chr16:30893963    G/C rs1241251631 chr16:30893956    T/A rs1288563923 chr16:30893956    T/TGGGGCC rs1307177311 chr16:30893953    G/A rs750763225 chr16:30893954    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CIITA	chr16:11013768(+) A-I      intronic chr16:11013744(+) A-I      intronic chr16:11013737(+) A-I      intronic chr16:11013734(+) A-I      intronic chr16:10984273(+) A-I      intronic chr16:11013776(+) A-I      intronic chr16:11022225(+) A-I      3'UTR chr16:11020572(+) A-I      3'UTR chr16:10986777(+) A-I      intronic chr16:10987501(+) A-I      intronic chr16:10987513(+) A-I      intronic chr16:10987961(+) A-I      intronic chr16:11006218(+) A-I      intronic chr16:11006223(+) A-I      intronic chr16:11007191(+) A-I      intronic chr16:11007308(+) A-I      intronic chr16:10986589(+) A-I      intronic chr16:10984353(+) A-I      intronic chr16:10983597(+) A-I      intronic chr16:10983556(+) A-I      intronic chr16:10983550(+) A-I      intronic chr16:10983502(+) A-I      intronic chr16:10983477(+) A-I      intronic chr16:10978437(+) A-I      intronic chr16:10978429(+) A-I      intronic chr16:10978427(+) A-I      intronic chr16:10976373(+) A-I      intronic chr16:10984333(+) A-I      intronic chr16:11007579(+) A-I      intronic chr16:10984283(+) A-I      intronic chr16:10984205(+) A-I      intronic chr16:10983598(+) A-I      intronic chr16:10986637(+) A-I      intronic chr16:10986612(+) A-I      intronic chr16:10986776(+) A-I      intronic chr16:11007370(+) A-I      intronic chr16:11007418(+) A-I      intronic chr16:11007613(+) A-I      intronic chr16:11020524(+) A-I      3'UTR chr16:11020497(+) A-I      3'UTR chr16:11020510(+) A-I      3'UTR chr16:11020515(+) A-I      3'UTR chr16:11020421(+) A-I      3'UTR chr16:11020523(+) A-I      3'UTR chr16:11020563(+) A-I      3'UTR chr16:11018352(+) A-I      3'UTR chr16:11019215(+) A-I      3'UTR chr16:11022383(+) A-I      3'UTR chr16:11022345(+) A-I      3'UTR chr16:11022215(+) A-I      3'UTR chr16:11018342(+) A-I      3'UTR chr16:11019402(+) A-I      3'UTR chr16:11022206(+) A-I      3'UTR chr16:11020589(+) A-I      3'UTR chr16:11007301(+) A-I      intronic chr16:11007542(+) A-I      intronic chr16:11007271(+) A-I      intronic chr16:10999440(+) A-I      intronic chr16:10987898(+) A-I      intronic chr16:11007609(+) A-I      intronic chr16:11007624(+) A-I      intronic chr16:11007608(+) A-I      intronic chr16:11019216(+) A-I      3'UTR chr16:11018367(+) A-I      3'UTR chr16:11020498(+) A-I      3'UTR chr16:11019264(+) A-I      3'UTR chr16:11018118(+) A-I      3'UTR chr16:11022409(+) A-I      3'UTR chr16:10984244(+) A-I      intronic chr16:10978296(+) A-I      intronic chr16:10989589(+) A-I      NonSyn:Asp->Gly chr16:11003731(+) A-I      intronic chr16:10983408(+) A-I      intronic chr16:11007272(+) A-I      intronic chr16:11013491(+) A-I      intronic chr16:10983470(+) A-I      intronic chr16:11007311(+) A-I      intronic chr16:10999363(+) A-I      intronic chr16:11007541(+) A-I      intronic chr16:11007433(+) A-I      intronic chr16:11007687(+) A-I      intronic chr16:11007568(+) A-I      intronic chr16:11008987(+) A-I      intronic chr16:11007378(+) A-I      intronic chr16:11008982(+) A-I      intronic chr16:10999862(+) A-I      intronic chr16:11007677(+) A-I      intronic chr16:10999362(+) A-I      intronic chr16:11007651(+) A-I      intronic chr16:10986636(+) A-I      intronic chr16:11007235(+) A-I      intronic chr16:11007763(+) A-I      intronic chr16:10975112(+) A-I      intronic chr16:10986580(+) A-I      intronic chr16:10984364(+) A-I      intronic chr16:11013492(+) A-I      intronic chr16:10987944(+) A-I      intronic chr16:10981590(+) A-I      intronic chr16:11007233(+) A-I      intronic chr16:11007236(+) A-I      intronic chr16:10986588(+) A-I      intronic chr16:10978295(+) A-I      intronic chr16:10975093(+) A-I      intronic chr16:10983396(+) A-I      intronic chr16:10986660(+) A-I      intronic chr16:10981446(+) A-I      intronic chr16:11008972(+) A-I      intronic chr16:11013729(+) A-I      intronic chr16:11013732(+) A-I      intronic chr16:11013743(+) A-I      intronic chr16:11013772(+) A-I      intronic chr16:10984287(+) A-I      intronic chr16:11013716(+) A-I      intronic chr16:11013733(+) A-I      intronic chr16:11013764(+) A-I      intronic chr16:11013728(+) A-I      intronic chr16:11013526(+) A-I      intronic chr16:11007753(+) A-I      intronic chr16:10976663(+) A-I      intronic chr16:11013527(+) A-I      intronic chr16:11013773(+) A-I      intronic chr16:11013612(+) A-I      intronic chr16:11007519(+) A-I      intronic chr16:11013634(+) A-I      intronic chr16:11013506(+) A-I      intronic chr16:11013709(+) A-I      intronic chr16:11013517(+) A-I      intronic chr16:11020578(+) A-I      3'UTR chr16:11020581(+) A-I      3'UTR chr16:11018312(+) A-I      3'UTR chr16:11022263(+) A-I      3'UTR chr16:11018279(+) A-I      3'UTR chr16:11018324(+) A-I      3'UTR chr16:11019263(+) A-I      3'UTR chr16:11019419(+) A-I      3'UTR chr16:11022250(+) A-I      3'UTR chr16:11022331(+) A-I      3'UTR chr16:11018220(+) A-I      3'UTR chr16:11020583(+) A-I      3'UTR chr16:11020478(+) A-I      3'UTR chr16:11018290(+) A-I      3'UTR chr16:11020434(+) A-I      3'UTR chr16:11020459(+) A-I      3'UTR chr16:11022214(+) A-I      3'UTR chr16:11020501(+) A-I      3'UTR chr16:11018230(+) A-I      3'UTR chr16:11020462(+) A-I      3'UTR chr16:11022249(+) A-I      3'UTR chr16:11022376(+) A-I      3'UTR chr16:11022328(+) A-I      3'UTR chr16:11018299(+) A-I      3'UTR chr16:11018232(+) A-I      3'UTR chr16:11019276(+) A-I      3'UTR chr16:11018191(+) A-I      3'UTR chr16:11020598(+) A-I      3'UTR chr16:11020502(+) A-I      3'UTR chr16:11018256(+) A-I      3'UTR chr16:11018240(+) A-I      3'UTR chr16:11018273(+) A-I      3'UTR chr16:11018310(+) A-I      3'UTR chr16:11022275(+) A-I      3'UTR chr16:11022245(+) A-I      3'UTR chr16:11022246(+) A-I      3'UTR chr16:11020595(+) A-I      3'UTR chr16:11018270(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CIITA	chr16:10989589(+) A-I exon CDS    15342557 chr16:10995933(+) A-I exon CDS    15342557 chr16:11002927(+) A-I exon CDS    15342557 chr16:11018118(+) A-I exon 3'UTR    15342557 chr16:11018220(+) A-I exon 3'UTR    15342557 chr16:11018230(+) A-I exon 3'UTR    15342557 chr16:11018232(+) A-I exon 3'UTR    15342557 chr16:11018240(+) A-I exon 3'UTR    15342557 chr16:11018270(+) A-I exon 3'UTR    15342557   //15258596 chr16:11018290(+) A-I exon 3'UTR    15342557   //15258596 chr16:11018299(+) A-I exon 3'UTR    15342557   //15258596 chr16:11018310(+) A-I exon 3'UTR    15342557   //15258596 chr16:11018324(+) A-I exon 3'UTR    15342557   //15258596 chr16:11013716(+) A-I intron -    22327324 chr16:11013732(+) A-I intron -    22327324 chr16:11013733(+) A-I intron -    22327324 chr16:11013716(+) A-G intron -    22484847 chr16:11013728(+) A-G intron -    22484847 chr16:11013729(+) A-G intron -    22484847 chr16:11013732(+) A-G intron -    22484847 chr16:11013733(+) A-G intron -    22484847 chr16:11013743(+) A-G intron -    22484847 chr16:11013764(+) A-G intron -    22484847 chr16:10999440(+) A-G intron -    22484847 chr16:11007608(+) A-G intron -    22484847 chr16:11007677(+) A-G intron -    22484847 chr16:11007687(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CIITA	chr16:10989249-10989250(+) m6A CDS//exon       - chr16:10989537-10989538(+) m6A CDS//exon       - chr16:10989596-10989597(+) m6A CDS//exon       - chr16:10992530-10992531(+) m6A CDS//exon       - chr16:10992535-10992536(+) m6A CDS//exon       - chr16:10992553-10992554(+) m6A CDS//exon       - chr16:10992580-10992581(+) m6A CDS//exon       - chr16:10992791-10992792(+) m6A CDS//exon       - chr16:10995934-10995935(+) m6A 3'UTR//CDS//exon//intron       - chr16:10996025-10996026(+) m6A 3'UTR//CDS//exon//intron       - chr16:10996560-10996561(+) m6A 3'UTR//CDS//exon       - chr16:10996627-10996628(+) m6A CDS//exon       - chr16:10997659-10997660(+) m6A CDS//exon       - chr16:10997720-10997721(+) m6A CDS//exon       - chr16:10997743-10997744(+) m6A CDS//exon       - chr16:11000388-11000389(+) m6A CDS//exon//intron       - chr16:11000491-11000492(+) m6A CDS//exon//intron       22575960 chr16:11000505-11000506(+) m6A CDS//exon//intron       22575960 chr16:11000585-11000586(+) m6A CDS//exon//intron       22575960 chr16:11000718-11000719(+) m6A CDS//exon//intron       - chr16:11001123-11001124(+) m6A CDS//exon//intron       - chr16:11001147-11001148(+) m6A CDS//exon//intron       - chr16:11001265-11001266(+) m6A CDS//exon//intron       - chr16:11001358-11001359(+) m6A CDS//exon//intron       22575960 chr16:11001381-11001382(+) m6A CDS//exon//intron       22575960 chr16:11001407-11001408(+) m6A CDS//exon//intron       22575960 chr16:11001537-11001538(+) m6A CDS//exon//intron       22575960 chr16:11001696-11001697(+) m6A CDS//exon//intron       22575960 chr16:11001746-11001747(+) m6A CDS//exon//intron       22575960 chr16:11001921-11001922(+) m6A CDS//exon//intron       22575960 chr16:11001933-11001934(+) m6A CDS//exon//intron       22575960 chr16:11001982-11001983(+) m6A CDS//exon//intron       - chr16:11002031-11002032(+) m6A CDS//exon//intron       - chr16:11002275-11002276(+) m6A 3'UTR//exon//intron       - chr16:11002368-11002369(+) m6A 3'UTR//exon//intron       - chr16:11002940-11002941(+) m6A CDS//exon//intron       - chr16:11004064-11004065(+) m6A CDS//exon       - chr16:11004094-11004095(+) m6A CDS//exon       - chr16:11004104-11004105(+) m6A 3'UTR//CDS//exon       - chr16:11009462-11009463(+) m6A 3'UTR//CDS//exon       - chr16:11017882-11017883(+) m6A 3'UTR//exon       - chr16:11017905-11017906(+) m6A 3'UTR//exon       - chr16:11018001-11018002(+) m6A 3'UTR//exon       - chr16:11018010-11018011(+) m6A 3'UTR//exon       - chr16:11018113-11018114(+) m6A 3'UTR//exon       - chr16:11018276-11018277(+) m6A 3'UTR//exon       - chr16:11018311-11018312(+) m6A 3'UTR//exon       - chr16:11018426-11018427(+) m6A 3'UTR//exon       - chr16:11018459-11018460(+) m6A 3'UTR//exon       - chr16:11018541-11018542(+) m6A 3'UTR//exon       22575960 chr16:11018613-11018614(+) m6A 3'UTR//exon       22575960 chr16:11018625-11018626(+) m6A 3'UTR//exon       22575960 chr16:11018650-11018651(+) m6A 3'UTR//exon       22575960 chr16:11022806-11022807(+) m6A 3'UTR//intron       27773535//22608085 chr16:11023011-11023012(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:11023029-11023030(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:11023045-11023046(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:11023183-11023184(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:11023204-11023205(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:11023372-11023373(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27371828//22608085 chr16:11023378-11023379(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27371828//22608085 chr16:11023482-11023483(+) m6A 3'UTR//intron       27371828 chr16:11023488-11023489(+) m6A 3'UTR//intron       27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-762	Exosome Pooled sera     27278097 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Hepatoma cells     23771658 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	CIITA	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleolus K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-762	Gemcitabine 60750 Drug interaction    RC00007981 Imatinib 5291 Drug interaction    RC00007980 Bortezomib 387447 Drug interaction    RC00007983 5-Fluorouracil 3385 Drug interaction    RC00007979 Gefitinib 123631 Drug interaction    RC00007982

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-762	Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-762
Interactor2: CIITA

Evidence Support:

Weak-Evidence	MiRNA microarray//RNA-Seq
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	30605755	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	A. Relationships between miRNAs and inversely correlated mRNAs involved in the influenza A pathway.