Detail Information

Basic Information:


  VIRBase ID:  

HHID00092792

  Virus:  

Influenza A virus (A/Brisbane/10/2007(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1915-3p:           DHX58:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1915-3p DHX58
miRBase
Accession/Entrez ID		 MIMAT0007892 79132
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - D11LGP2//D11lgp2e//LGP2//RLR-3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1915-3p
rs1319660164 chr10:21496576    C/T
rs1335396985 chr10:21496581    C/G
rs1359100620 chr10:21496582    G/A
rs1416262346 chr10:21496578    C/A
rs540277336 chr10:21496579    G/A
rs540277336 chr10:21496579    G/C
rs983068182 chr10:21496591    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DHX58
chr17:40256119(-) A-I      intronic
chr17:40255025(-) A-I      intronic
chr17:40256117(-) A-I      intronic
chr17:40256179(-) A-I      intronic
chr17:40256210(-) A-I      intronic
chr17:40258816(-) A-I      intronic
chr17:40254939(-) A-I      intronic
chr17:40254930(-) A-I      intronic
chr17:40255987(-) A-I      intronic
chr17:40255998(-) A-I      intronic
chr17:40255072(-) A-I      intronic
chr17:40258631(-) A-I      intronic
chr17:40255101(-) A-I      intronic
chr17:40254966(-) A-I      intronic
chr17:40256158(-) A-I      intronic
chr17:40254917(-) A-I      intronic
chr17:40254904(-) A-I      intronic
chr17:40254975(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DHX58
chr17:40253673(-) A-C exon 3'UTR    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DHX58
chr17:40253537-40253538(-) m6A 3'UTR       28052920//27773535
chr17:40253570-40253571(-) m6A 3'UTR       28052920//27773535
chr17:40253591-40253592(-) m6A 3'UTR       28052920//27773535
chr17:40253619-40253620(-) m6A 3'UTR//exon       27773535
chr17:40253719-40253720(-) m6A 3'UTR//exon       27371828
chr17:40253782-40253783(-) m6A 3'UTR//CDS//exon       27371828
chr17:40253794-40253795(-) m6A 3'UTR//CDS//exon       27371828
chr17:40253803-40253804(-) m6A 3'UTR//CDS//exon       27371828
chr17:40253891-40253892(-) m6A 3'UTR//CDS//exon       27371828
chr17:40254243-40254244(-) m6A 3'UTR//CDS//exon       -
chr17:40254276-40254277(-) m6A 3'UTR//CDS//exon       -
chr17:40254327-40254328(-) m6A CDS//exon       -
chr17:40254407-40254408(-) m6A exon//intron       -
chr17:40254485-40254486(-) m6A exon//intron       27773535
chr17:40254528-40254529(-) m6A exon//intron       27773535
chr17:40254554-40254555(-) m6A exon//intron       27773535
chr17:40254563-40254564(-) m6A exon//intron       27773535
chr17:40254575-40254576(-) m6A exon//intron       27773535
chr17:40254667-40254668(-) m6A exon//intron       27773535
chr17:40255754-40255755(-) m6A CDS//exon//intron       27371828
chr17:40256805-40256806(-) m6A CDS//exon       27371828
chr17:40257138-40257139(-) m6A CDS//exon       27371828
chr17:40257145-40257146(-) m6A CDS//exon       27371828
chr17:40257180-40257181(-) m6A CDS//exon       27371828
chr17:40257781-40257782(-) m6A CDS//exon//intron       27371828
chr17:40257814-40257815(-) m6A CDS//exon//intron       27371828
chr17:40257821-40257822(-) m6A CDS//exon//intron       27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1915-3p
Exosome Pooled sera     27278097
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
DHX58
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1915-3p
Interactor2: DHX58

Evidence Support:


Weak-Evidence MiRNA microarray//RNA-Seq
Prediction-Evidence microRNA.org//PITA//Targetscan
Support Database ViRBase

References:


PMID 30605755 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line A549 cells Interactor2 expression Upregulation
Description B. Relationships between miRNAs and inversely correlated mRNAs involved in the host defense to virus. Green and red represent downregulated and upregulated genes, while triangles and circles represent miRNAs and target gene mRNAs, respectively.

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