Basic Information:

  VIRBase ID:  

HHID00092784

  Virus:  

Influenza A virus (A/Brisbane/10/2007(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.9124

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1915-3p:  MIMAT0007892          OAS2:  NM_002535     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1915-3p	OAS2
miRBase Accession/Entrez ID	MIMAT0007892	4939
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1915-3p	rs1319660164 chr10:21496576    C/T rs1335396985 chr10:21496581    C/G rs1359100620 chr10:21496582    G/A rs1416262346 chr10:21496578    C/A rs540277336 chr10:21496579    G/A rs540277336 chr10:21496579    G/C rs983068182 chr10:21496591    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OAS2	chr12:113439615(+) A-I      intronic chr12:113432356(+) A-I      intronic chr12:113432246(+) A-I      intronic chr12:113443749(+) A-I      intronic chr12:113437785(+) A-I      intronic chr12:113443267(+) A-I      intronic chr12:113440196(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OAS2	chr12:113416318-113416319(+) m6A 5'UTR       - chr12:113425228-113425229(+) m6A 3'UTR//intron       - chr12:113425235-113425236(+) m6A 3'UTR//intron       - chr12:113425268-113425269(+) m6A 3'UTR//intron       - chr12:113425287-113425288(+) m6A 3'UTR//intron       - chr12:113425392-113425393(+) m6A 3'UTR//intron       - chr12:113446941-113446942(+) m6A CDS       - chr12:113447012-113447013(+) m6A CDS       24981863 chr12:113447019-113447020(+) m6A CDS       24981863 chr12:113447107-113447108(+) m6A 3'UTR//intron       24981863 chr12:113447142-113447143(+) m6A 3'UTR//intron       24981863 chr12:113447157-113447158(+) m6A 3'UTR//intron       24981863 chr12:113447178-113447179(+) m6A 3'UTR//intron       24981863 chr12:113447330-113447331(+) m6A 3'UTR//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1915-3p	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	OAS2	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1915-3p
Interactor2: OAS2

Evidence Support:

Strong-Evidence	RT-qPCR
Weak-Evidence	MiRNA microarray//RNA-Seq
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	30605755	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	Table 1. Relationships between 8 miRNAs and inversely correlated 13 target genes selected in RT-qPCR.