Basic Information:

  VIRBase ID:  

HHID00092783

  Virus:  

Influenza A virus (A/Brisbane/10/2007(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1915-3p:  MIMAT0007892          MYD88:  NR_164663     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1915-3p	MYD88
miRBase Accession/Entrez ID	MIMAT0007892	4615
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IMD68//MYD88D

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1915-3p	rs1319660164 chr10:21496576    C/T rs1335396985 chr10:21496581    C/G rs1359100620 chr10:21496582    G/A rs1416262346 chr10:21496578    C/A rs540277336 chr10:21496579    G/A rs540277336 chr10:21496579    G/C rs983068182 chr10:21496591    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MYD88	chr3:38182641(+) A-I intron -    22327324

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MYD88	chr3:38180149-38180150(+) m6A 5'UTR//exon       25456834//24981863 chr3:38180181-38180182(+) m6A CDS//exon       25456834//24981863 chr3:38180311-38180312(+) m6A CDS//exon       25456834//24981863 chr3:38180332-38180333(+) m6A CDS//exon       25456834//24981863//26404942 chr3:38180354-38180355(+) m6A CDS//exon       25456834//24981863//26404942 chr3:38180386-38180387(+) m6A CDS//exon       24981863//26404942 chr3:38180396-38180397(+) m6A CDS//exon       26404942 chr3:38180508-38180509(+) m6A CDS//exon       - chr3:38180651-38180652(+) m6A exon//intron       - chr3:38182744-38182745(+) m6A 3'UTR//CDS//exon       24209618//25456834//24981863//22575960 chr3:38182779-38182780(+) m6A 3'UTR//exon       24209618//25456834//24981863//22575960 chr3:38182911-38182912(+) m6A 3'UTR//exon       24209618//25456834//24981863//22575960 chr3:38182930-38182931(+) m6A 3'UTR//exon       24209618//25456834//24981863//26404942//22575960 chr3:38182956-38182957(+) m6A 3'UTR//exon       24209618//25456834//24981863//26404942//22575960 chr3:38183003-38183004(+) m6A 3'UTR//exon       24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:38183013-38183014(+) m6A 3'UTR//exon       24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:38183018-38183019(+) m6A 3'UTR//exon       24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:38183028-38183029(+) m6A 3'UTR//exon       24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:38183038-38183039(+) m6A 3'UTR//exon       24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:38183118-38183119(+) m6A 3'UTR//exon       24209618//25456834//24981863//22608085 chr3:38183186-38183187(+) m6A 3'UTR//exon       24209618//25456834//24981863//22608085 chr3:38183222-38183223(+) m6A 3'UTR//exon       24209618//25456834//24981863 chr3:38183377-38183378(+) m6A 3'UTR//exon       24209618//24981863 chr3:38183479-38183480(+) m6A 3'UTR//exon       25456834//24981863 chr3:38183718-38183719(+) m6A 3'UTR//exon       27773535 chr3:38183776-38183777(+) m6A 3'UTR//exon       24981863//27773535 chr3:38183788-38183789(+) m6A 3'UTR//exon       24981863//27773535 chr3:38183808-38183809(+) m6A 3'UTR//exon       24981863//27773535 chr3:38183871-38183872(+) m6A 3'UTR//exon       24981863//27773535 chr3:38183922-38183923(+) m6A 3'UTR//exon       24981863 chr3:38183975-38183976(+) m6A 3'UTR//exon       24981863 chr3:38183980-38183981(+) m6A 3'UTR//exon       24981863 chr3:38183992-38183993(+) m6A 3'UTR//exon       24981863 chr3:38184053-38184054(+) m6A 3'UTR//exon       24981863//26404942 chr3:38184069-38184070(+) m6A 3'UTR//exon       24981863//26404942 chr3:38184076-38184077(+) m6A 3'UTR//exon       24981863//26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1915-3p	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	MYD88	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1915-3p
Interactor2: MYD88

Evidence Support:

Weak-Evidence	MiRNA microarray//RNA-Seq
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	30605755	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	A. Relationships between miRNAs and inversely correlated mRNAs involved in the influenza A pathway.