Basic Information:

  VIRBase ID:  

HHID00092781

  Virus:  

Influenza A virus (A/Brisbane/10/2007(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1915-3p:  MIMAT0007892          ISG20:  NR_130134     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1915-3p	ISG20
miRBase Accession/Entrez ID	MIMAT0007892	3669
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD25//HEM45

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1915-3p	rs1319660164 chr10:21496576    C/T rs1335396985 chr10:21496581    C/G rs1359100620 chr10:21496582    G/A rs1416262346 chr10:21496578    C/A rs540277336 chr10:21496579    G/A rs540277336 chr10:21496579    G/C rs983068182 chr10:21496591    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ISG20	chr15:89184992(+) A-I      intronic chr15:89185002(+) A-I      intronic chr15:89186254(+) A-I      intronic chr15:89186314(+) A-I      intronic chr15:89185004(+) A-I      intronic chr15:89186369(+) A-I      intronic chr15:89187548(+) A-I      intronic chr15:89187589(+) A-I      intronic chr15:89184963(+) A-I      intronic chr15:89184962(+) A-I      intronic chr15:89184956(+) A-I      intronic chr15:89184927(+) A-I      intronic chr15:89184349(+) A-I      intronic chr15:89184316(+) A-I      intronic chr15:89184139(+) A-I      intronic chr15:89186876(+) A-I      intronic chr15:89187613(+) A-I      intronic chr15:89184117(+) A-I      intronic chr15:89184008(+) A-I      intronic chr15:89183996(+) A-I      intronic chr15:89187625(+) A-I      intronic chr15:89187652(+) A-I      intronic chr15:89187665(+) A-I      intronic chr15:89187774(+) A-I      intronic chr15:89185239(+) A-I      intronic chr15:89186313(+) A-I      intronic chr15:89190021(+) A-I      intronic chr15:89186245(+) A-I      intronic chr15:89185123(+) A-I      intronic chr15:89186206(+) A-I      intronic chr15:89190076(+) A-I      intronic chr15:89190095(+) A-I      intronic chr15:89190101(+) A-I      intronic chr15:89190102(+) A-I      intronic chr15:89190105(+) A-I      intronic chr15:89186191(+) A-I      intronic chr15:89186109(+) A-I      intronic chr15:89186028(+) A-I      intronic chr15:89186000(+) A-I      intronic chr15:89185948(+) A-I      intronic chr15:89185891(+) A-I      intronic chr15:89185867(+) A-I      intronic chr15:89185394(+) A-I      intronic chr15:89186860(+) A-I      intronic chr15:89186828(+) A-I      intronic chr15:89186758(+) A-I      intronic chr15:89186736(+) A-I      intronic chr15:89186734(+) A-I      intronic chr15:89186673(+) A-I      intronic chr15:89186884(+) A-I      intronic chr15:89186895(+) A-I      intronic chr15:89186411(+) A-I      intronic chr15:89186407(+) A-I      intronic chr15:89186045(+) A-I      intronic chr15:89186121(+) A-I      intronic chr15:89185343(+) A-I      intronic chr15:89186056(+) A-I      intronic chr15:89186815(+) A-I      intronic chr15:89185941(+) A-I      intronic chr15:89183993(+) A-I      intronic chr15:89184019(+) A-I      intronic chr15:89184478(+) A-I      intronic chr15:89184465(+) A-I      intronic chr15:89186415(+) A-I      intronic chr15:89186777(+) A-I      intronic chr15:89186310(+) A-I      intronic chr15:89183940(+) A-I      intronic chr15:89183937(+) A-I      intronic chr15:89187603(+) A-I      intronic chr15:89186200(+) A-I      intronic chr15:89185011(+) A-I      intronic chr15:89187614(+) A-I      intronic chr15:89185928(+) A-I      intronic chr15:89186269(+) A-I      intronic chr15:89185327(+) A-I      intronic chr15:89186784(+) A-I      intronic chr15:89186788(+) A-I      intronic chr15:89187669(+) A-I      intronic chr15:89186319(+) A-I      intronic chr15:89183931(+) A-I      intronic chr15:89187600(+) A-I      intronic chr15:89184009(+) A-I      intronic chr15:89185434(+) A-I      intronic chr15:89186870(+) A-I      intronic chr15:89185989(+) A-I      intronic chr15:89197234(+) A-I      intronic chr15:89186421(+) A-I      intronic chr15:89184075(+) A-I      intronic chr15:89185265(+) A-I      intronic chr15:89185436(+) A-I      intronic chr15:89185037(+) A-I      intronic chr15:89186315(+) A-I      intronic chr15:89197078(+) A-I      intronic chr15:89187588(+) A-I      intronic chr15:89183939(+) A-I      intronic chr15:89187503(+) A-I      intronic chr15:89186082(+) A-I      intronic chr15:89185872(+) A-I      intronic chr15:89185125(+) A-I      intronic chr15:89187587(+) A-I      intronic chr15:89187644(+) A-I      intronic chr15:89184304(+) A-I      intronic chr15:89187609(+) A-I      intronic chr15:89186814(+) A-I      intronic chr15:89187510(+) A-I      intronic chr15:89185869(+) A-I      intronic chr15:89186841(+) A-I      intronic chr15:89184365(+) A-I      intronic chr15:89185046(+) A-I      intronic chr15:89186733(+) A-I      intronic chr15:89185264(+) A-I      intronic chr15:89186391(+) A-I      intronic chr15:89185873(+) A-I      intronic chr15:89186316(+) A-I      intronic chr15:89185326(+) A-I      intronic chr15:89187579(+) A-I      intronic chr15:89185985(+) A-I      intronic chr15:89186680(+) A-I      intronic chr15:89184353(+) A-I      intronic chr15:89184059(+) A-I      intronic chr15:89186854(+) A-I      intronic chr15:89185302(+) A-I      intronic chr15:89184354(+) A-I      intronic chr15:89190025(+) A-I      intronic chr15:89185925(+) A-I      intronic chr15:89186259(+) A-I      intronic chr15:89185297(+) A-I      intronic chr15:89186783(+) A-I      intronic chr15:89187643(+) A-I      intronic chr15:89185369(+) A-I      intronic chr15:89185084(+) A-I      intronic chr15:89183966(+) A-I      intronic chr15:89186031(+) A-I      intronic chr15:89184110(+) A-I      intronic chr15:89187617(+) A-I      intronic chr15:89185977(+) A-I      intronic chr15:89187684(+) A-I      intronic chr15:89186785(+) A-I      intronic chr15:89185927(+) A-I      intronic chr15:89184427(+) A-I      intronic chr15:89186782(+) A-I      intronic chr15:89186022(+) A-I      intronic chr15:89183994(+) A-I      intronic chr15:89186770(+) A-I      intronic chr15:89184051(+) A-I      intronic chr15:89186240(+) A-I      intronic chr15:89186199(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ISG20	chr15:89183937(+) A-I intron -    22327324 chr15:89185925(+) A-I intron -    22327324 chr15:89185941(+) A-I intron -    22327324 chr15:89186056(+) A-I intron -    22327324 chr15:89183931(+) A-G intron -    22484847 chr15:89183937(+) A-G intron -    22484847 chr15:89183966(+) A-G intron -    22484847 chr15:89184009(+) A-G intron -    22484847 chr15:89184075(+) A-G intron -    22484847 chr15:89184110(+) A-G intron -    22484847 chr15:89184354(+) A-G intron -    22484847 chr15:89184365(+) A-G intron -    22484847 chr15:89185436(+) A-G intron -    22484847 chr15:89185925(+) A-G intron -    22484847 chr15:89185928(+) A-G intron -    22484847 chr15:89185941(+) A-G intron -    22484847 chr15:89185989(+) A-G intron -    22484847 chr15:89186056(+) A-G intron -    22484847 chr15:89186121(+) A-G intron -    22484847 chr15:89186199(+) A-G intron -    22484847 chr15:89186391(+) A-G intron -    22484847 chr15:89186421(+) A-G intron -    22484847 chr15:89187614(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ISG20	chr15:89182396-89182397(+) m6A exon//intron       24209618//24981863 chr15:89182595-89182596(+) m6A 5'UTR//exon       24209618//24981863 chr15:89182628-89182629(+) m6A CDS//exon       24209618//24981863 chr15:89182756-89182757(+) m6A CDS//exon       24209618 chr15:89195150-89195151(+) m6A exon//intron       - chr15:89195413-89195414(+) m6A CDS//exon       - chr15:89195479-89195480(+) m6A CDS//exon       - chr15:89198757-89198758(+) m6A CDS//exon       24981863 chr15:89198788-89198789(+) m6A 3'UTR//exon       24981863 chr15:89198812-89198813(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1915-3p	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ISG20	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1915-3p
Interactor2: ISG20

Evidence Support:

Weak-Evidence	MiRNA microarray//RNA-Seq
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	30605755	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	B. Relationships between miRNAs and inversely correlated mRNAs involved in the host defense to virus. Green and red represent downregulated and upregulated genes, while triangles and circles represent miRNAs and target gene mRNAs, respectively.