Basic Information:

  VIRBase ID:  

HHID00092754

  Virus:  

Influenza A virus (A/Brisbane/10/2007(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-371a-5p:  MIMAT0004687          JAK2:  NR_169764     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-371a-5p	JAK2
miRBase Accession/Entrez ID	MIMAT0004687	3717
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	JTK10

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-371a-5p	rs1004685112 chr19:53787689    G/C rs1318684148 chr19:53787691    G/C rs772543475 chr19:53787692    G/C rs1034874198 chr19:53787693    G/C rs1049004182 chr19:53787684    A/C rs1049004182 chr19:53787684    A/G rs1185000692 chr19:53787682    T/C rs1202234248 chr19:53787687    C/T rs1428290628 chr19:53787686    A/AC rs1480794990 chr19:53787686    A/C rs770734168 chr19:53787687    CTG/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	JAK2	chr9:5102325(+) A-I      intronic chr9:5025674(+) A-I      intronic chr9:5025678(+) A-I      intronic chr9:5064281(+) A-I      intronic chr9:5102353(+) A-I      intronic chr9:5102375(+) A-I      intronic chr9:5120073(+) A-I      intronic chr9:5102378(+) A-I      intronic chr9:5102381(+) A-I      intronic chr9:5102389(+) A-I      intronic chr9:5120051(+) A-I      intronic chr9:5120066(+) A-I      intronic chr9:5064291(+) A-I      intronic chr9:5120089(+) A-I      intronic chr9:5120098(+) A-I      intronic chr9:5025742(+) A-I      intronic chr9:5025663(+) A-I      intronic chr9:5025608(+) A-I      intronic chr9:5085751(+) A-I      intronic chr9:5085772(+) A-I      intronic chr9:5085787(+) A-I      intronic chr9:5085806(+) A-I      intronic chr9:5112688(+) A-I      intronic chr9:5112689(+) A-I      intronic chr9:5112702(+) A-I      intronic chr9:5102318(+) A-I      intronic chr9:5102317(+) A-I      intronic chr9:5102328(+) A-I      intronic chr9:5102336(+) A-I      intronic chr9:5102351(+) A-I      intronic chr9:5112730(+) A-I      intronic chr9:5102331(+) A-I      intronic chr9:5025672(+) A-I      intronic chr9:4996305(+) A-I      intronic chr9:4996359(+) A-I      intronic chr9:4996380(+) A-I      intronic chr9:5021767(+) A-I      intronic chr9:5025627(+) A-I      intronic chr9:5102383(+) A-I      intronic chr9:5005212(+) A-I      intronic chr9:4996298(+) A-I      intronic chr9:4997041(+) A-I      intronic chr9:5042150(+) A-I      intronic chr9:5021764(+) A-I      intronic chr9:5021758(+) A-I      intronic chr9:5005188(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	JAK2	chr9:4985095-4985096(+) m6A exon       24981863 chr9:5090814-5090815(+) m6A CDS       24981863 chr9:5090862-5090863(+) m6A CDS       24981863 chr9:5111064-5111065(+) m6A intron       - chr9:5111103-5111104(+) m6A intron       - chr9:5114531-5114532(+) m6A intron       - chr9:5114537-5114538(+) m6A intron       - chr9:5114567-5114568(+) m6A intron       - chr9:5114582-5114583(+) m6A intron       - chr9:5126813-5126814(+) m6A 3'UTR//exon       24981863 chr9:5126832-5126833(+) m6A 3'UTR//exon       24981863 chr9:5126861-5126862(+) m6A 3'UTR//exon       24981863//22608085 chr9:5126934-5126935(+) m6A 3'UTR//exon       24981863//22608085 chr9:5126981-5126982(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-371a-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     - Nucleus Nasopharyngeal carcinoma cells     20498841
	JAK2	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-371a-5p	10-Hydroxycamptothecin 97226 Drug interaction    RC00007074 Gemcitabine 60750 Drug interaction    RC00007073 Progesterone 5994 Drug interaction    RC00007072 Calcitriol 5280453 Drug interaction    RC00007075 5-Fluorouracil 3385 Drug interaction    RC00007071 Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00007076

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-371a-5p	CID 14440697 14440697       21293479

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-371a-5p
Interactor2: JAK2

Evidence Support:

Weak-Evidence	MiRNA microarray//RNA-Seq
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	30605755	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	A. Relationships between miRNAs and inversely correlated mRNAs involved in the influenza A pathway.