Detail Information

Basic Information:


  VIRBase ID:  

HHID00092742

  Virus:  

Influenza A virus (A/Brisbane/10/2007(H3N2))

  Host:  

Homo sapiens

  Confidence Score:  

0.9124

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-296-5p:           MX2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-296-5p MX2
miRBase
Accession/Entrez ID		 MIMAT0000690 4600
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MXB

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-296-5p
rs1054118526 chr20:58817664    G/A
rs1185522862 chr20:58817668    T/C
rs1483946538 chr20:58817667    T/C
rs747039644 chr20:58817670    AG/AGG
rs747039644 chr20:58817670    AG/A
rs764720130 chr20:58817672    G/C
rs912852078 chr20:58817671    G/A
rs1164873545 chr20:58817676    G/A
rs1473070921 chr20:58817675    G/T
rs754356943 chr20:58817677    G/A
rs757807177 chr20:58817678    C/A
rs757807177 chr20:58817678    C/G
rs765680924 chr20:58817680    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MX2
chr21:42777078(+) A-I      intronic
chr21:42777026(+) A-I      intronic
chr21:42763388(+) A-I      intronic
chr21:42763435(+) A-I      intronic
chr21:42763436(+) A-I      intronic
chr21:42764798(+) A-I      intronic
chr21:42764822(+) A-I      intronic
chr21:42764856(+) A-I      intronic
chr21:42764870(+) A-I      intronic
chr21:42764886(+) A-I      intronic
chr21:42764912(+) A-I      intronic
chr21:42764913(+) A-I      intronic
chr21:42764918(+) A-I      intronic
chr21:42762670(+) A-I      intronic
chr21:42765012(+) A-I      intronic
chr21:42766621(+) A-I      intronic
chr21:42776981(+) A-I      intronic
chr21:42763337(+) A-I      intronic
chr21:42777011(+) A-I      intronic
chr21:42777127(+) A-I      intronic
chr21:42763382(+) A-I      intronic
chr21:42748437(+) A-I      intronic
chr21:42762754(+) A-I      intronic
chr21:42762878(+) A-I      intronic
chr21:42763449(+) A-I      intronic
chr21:42764878(+) A-I      intronic
chr21:42763378(+) A-I      intronic
chr21:42777020(+) A-I      intronic
chr21:42777883(+) A-I      intronic
chr21:42761405(+) A-I      intronic
chr21:42778158(+) A-I      intronic
chr21:42766614(+) A-I      intronic
chr21:42777090(+) A-I      intronic
chr21:42777169(+) A-I      intronic
chr21:42777841(+) A-I      intronic
chr21:42778177(+) A-I      intronic
chr21:42755128(+) A-I      intronic
chr21:42763529(+) A-I      intronic
chr21:42776958(+) A-I      intronic
chr21:42777996(+) A-I      intronic
chr21:42757987(+) A-I      intronic
chr21:42762818(+) A-I      intronic
chr21:42777812(+) A-I      intronic
chr21:42766747(+) A-I      intronic
chr21:42777060(+) A-I      intronic
chr21:42762786(+) A-I      intronic
chr21:42778150(+) A-I      intronic
chr21:42762812(+) A-I      intronic
chr21:42762769(+) A-I      intronic
chr21:42777021(+) A-I      intronic
chr21:42763350(+) A-I      intronic
chr21:42763439(+) A-I      intronic
chr21:42777203(+) A-I      intronic
chr21:42761435(+) A-I      intronic
chr21:42778149(+) A-I      intronic
chr21:42764981(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MX2
chr21:42735274(+) A-G intron -    22484847
chr21:42762812(+) A-G intron -    22484847
chr21:42762818(+) A-G intron -    22484847
chr21:42763444(+) A-G intron -    22484847
chr21:42763449(+) A-G intron -    22484847
chr21:42763489(+) A-G intron -    22484847
chr21:42763492(+) A-G intron -    22484847
chr21:42777020(+) A-G intron -    22484847
chr21:42777059(+) A-G intron -    22484847
chr21:42777169(+) A-G intron -    22484847
chr21:42777170(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MX2
chr21:42738742-42738743(+) m6A exon//intron       -
chr21:42738835-42738836(+) m6A exon//intron       -
chr21:42738857-42738858(+) m6A exon//intron       -
chr21:42738908-42738909(+) m6A exon//intron       -
chr21:42738928-42738929(+) m6A exon//intron       -
chr21:42738947-42738948(+) m6A exon//intron       -
chr21:42738953-42738954(+) m6A exon//intron       -
chr21:42738961-42738962(+) m6A exon//intron       -
chr21:42738979-42738980(+) m6A exon//intron       -
chr21:42742141-42742142(+) m6A 5'UTR//intron       -
chr21:42742162-42742163(+) m6A 5'UTR//intron       -
chr21:42742228-42742229(+) m6A 5'UTR//intron       -
chr21:42742443-42742444(+) m6A 5'UTR//intron       -
chr21:42749017-42749018(+) m6A CDS       -
chr21:42749038-42749039(+) m6A CDS       -
chr21:42749059-42749060(+) m6A CDS       -
chr21:42749725-42749726(+) m6A CDS       -
chr21:42762564-42762565(+) m6A CDS//exon       -
chr21:42762606-42762607(+) m6A CDS//exon       -
chr21:42762618-42762619(+) m6A CDS//exon       -
chr21:42771144-42771145(+) m6A CDS//exon//intron       27773535
chr21:42771191-42771192(+) m6A CDS//exon//intron       27773535
chr21:42771228-42771229(+) m6A CDS//exon//intron       27773535
chr21:42771292-42771293(+) m6A exon//intron       27773535
chr21:42780064-42780065(+) m6A CDS//exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-296-5p
Exosome Serum     18589210
Exosome Renal cancer cells     21670082
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
MX2
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-296-5p
Sensorad 99342 Drug sensitive
Kahalalide F 9898671 Drug resistant
Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive
3-Amino-7-(dimethylamino)-5-phenylphenazinium chloride 75442 Drug sensitive
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive
Venenatine 73061 Drug sensitive
Redoxal 72571 Drug sensitive
Sulbentine 67686 Drug sensitive
NO Data IN this field 6711510 Drug sensitive
(2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 6477178 Drug sensitive
Ixabepilone 6445540 Drug sensitive
Cytarabine 6253 Drug sensitive
Bizelesin 60794 Drug sensitive
Piriqualone 6015423 Drug sensitive
Triethylenemelamine 5799 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
Caracemide 54747 Drug sensitive
Artelasticin 5471311 Drug sensitive
Antineoplastic-690266 5469577 Drug sensitive
3-Deazauridine 54684286 Drug sensitive
2,10-Anthrylenedimethylene)-bis[2-thiopseudourea] dihydrochloride 54603799 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Thiram 5455 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
5-Phenyl-N-(3,4,5-trimethoxyphenyl)-1,3-oxazol-2-amine 5329854 Drug sensitive
7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug sensitive
Vorinostat 5311 Drug sensitive
Kekule 499328 Drug sensitive
Ammonia; dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498559 Drug sensitive
Propyl gallate 4947 Drug resistant
1,4-Benzoquinone 4650 Drug sensitive
L-Cysteine analog 457392 Drug sensitive
Aclarubicin 451415 Drug sensitive
BAS100 Monohydrate 45028404 Drug sensitive
Mycophenolic acid 446541 Drug sensitive
1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive
Isopinnatal 44558939 Drug sensitive
Iproplatin 44214 Drug sensitive
Oridonin (thiol adduct OF) 432952 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
Cyano pyridine-P-CH3 406496 Drug sensitive
Aminopyrimidine-CH3 406278 Drug sensitive
(2S)-2,6-Diamino-N-[4-(5-amino-6,8-difluoro-7-methyl-4-oxochromen-2-yl)-2-fluorophenyl]hexanamide;methanesulfonic acid 399587 Drug sensitive
Artelastin 399488 Drug sensitive
5'-Formyl-2,5-bis(2'-selenyl)-N-methylpyrrol 394652 Drug sensitive
Amino MMI-S02 CI 393532 Drug sensitive
Sjg-136 393111 Drug sensitive
beta-Lapachone 3885 Drug sensitive
Lapachol 3884 Drug sensitive
2-(1-Propynyl)estradiol 388008 Drug sensitive
1,3-Diphenyl-6-((triphenylphosphoranylidene)amino)-2,4(1H,3H)-pyrimidinedione 387460 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
Sanguilutine pseudobase 371258 Drug sensitive
1,2-Dimethyl-phenothiazone 369387 Drug sensitive
Maxima isoflavone D 343081 Drug sensitive
Buellolide 337850 Drug sensitive
2,2',3,3'-Tetrahydroxy-1,1'-binaphthyl 316673 Drug sensitive
Bromocriptine 31101 Drug sensitive
1,1-Dimethyl-5-(2-naphthalenyl)dithiobiuret 3004012 Drug sensitive
Phenanthrene-9,10-diimine 2981 Drug sensitive
Dichloroallyl lawsone 277767 Drug sensitive
Chlorambucil 2708 Drug sensitive
Hydrazine sulfate 24842 Drug sensitive
Antimycin A3 245869 Drug sensitive
Sarcoviolin 24202820 Drug sensitive
Prumycin HCl 24197905 Drug resistant
[(1S,2Z,4R,8R,9R,11R,13S)-13-Acetyloxy-1-hydroxy-2,11-dimethyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] 2-methylpropanoate 23255746 Drug sensitive
Drostanolone propionate 224004 Drug sensitive
Nile Blue 2B 20520 Drug sensitive
P-Dioxane,5-bis[(benzoyloxymercuri)methyl]- 16683647 Drug sensitive
Dihydrotriazine derivative 160202 Drug sensitive
(2Z,9E,13Z,15E)-4',11-Dihydroxy-2,4',9-trimethylspiro[3-aza-1(2,4)-thiazolacyclohexadecaphanene-6,3'-[1,2]dithiolane]-9,13,15-triene-4,5',12-trione 2'-oxide 154730760 Drug sensitive
Amphethinile 146332 Drug sensitive
Diphenyltin dichloride 14342 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
Gentian violet 11057 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
Withajardin C 102469053 Drug sensitive
(1S,2R,4R,6S,11R,12S,15R,18S,19R,20R,21S,23R,26R)-15-Hydroxy-11,18,21-trimethyl-5,17,24,28,29-pentaoxanonacyclo[17.9.1.11,20.02,12.04,6.06,11.015,19.018,23.021,26]triacont-8-ene-10,16,25,30-tetrone 101528280 Drug sensitive
(3S,6S)-1,4-Dimethyl-3,6-bis[(2R)-3,3,3-trichloro-2-methylpropyl]piperazine-2,5-dione 101425118 Drug sensitive
Chimaphilin 101211 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
Tocladesine 100299 Drug sensitive
2,3-dihydro-1,2-syn-3-[phenylseleno]brefeldin a - Drug resistant
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
tp4ek - Drug resistant
tunicamycin - Drug resistant
(Z)-N-phenyl-3-(3,4,5-trimethoxystyryl)pyridin-2-amine - Drug sensitive
1,8-naphthyridin-4(1h)-one, 2-(4-fluorophenyl)-5-methyl- - Drug sensitive
1h-1,4,7-triazonine-1,4,7-triacetic acid, octahydro- - Drug sensitive
1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
4(1h)-quinazolinone, 2,3-dihydro-2-(1-naphthyl)- (8ci) - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 2-phenyl- - Drug sensitive
acetamide, n-(2-mercaptoethyl)-, benzoate (6ci, 7ci) - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
bersaldegenin 1,3,5-orthoacetate - Drug sensitive
cis-2-hydroxymethyl-4-(5'-bromocytosin-1'-yl)-1,3-dioxolane - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive
isoindolo[1,2-b]quinazoline, 10,12-dihydro-3-methyl-12-oxo- - Drug sensitive
thiourea, n-(1-ethylpropyl)-n'-[(2-thienyl)thioxomethyl]- - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
[bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug sensitive
2'-deoxy-2'-difluoromethylene-adenosine - Drug sensitive
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive
5-methoxy camptothecin - Drug sensitive
antineoplastic-d665839 - Drug sensitive
Camptothecin Derivative - Drug sensitive
chlorambucil-spermidine - Drug sensitive
organosulfur compound - Drug sensitive
Soluble Baker's Antifol - Drug sensitive
Tetraplatin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-296-5p
Hyaluronidase 91820602 Drug interaction    RC00003980
Cianidanol 9064 Drug interaction    RC00003974
Capecitabine 60953 Drug interaction    RC00003977
Vincristine 5978 Drug interaction    RC00003973
D-Glucose 5793 Drug interaction    RC00003972
Sunitinib 5329102 Drug interaction    RC00003979
Imatinib 5291 Drug interaction    RC00003971
Paclitaxel 36314 Drug interaction    RC00003976
5-Fluorouracil 3385 Drug interaction    RC00003970
Doxorubicin 31703 Drug interaction    RC00003975
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003969
Ginsenoside Rh2 119307 Drug interaction    RC00003978
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003981
Trastuzumab - Drug interaction    RC00003982
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-296-5p
Cisplatin 5702198       21575166
Imatinib 5291       25349971
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-296-5p
Selumetinib       10127622

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-296-5p
Interactor2: MX2

Evidence Support:


Strong-Evidence RT-qPCR
Weak-Evidence MiRNA microarray//RNA-Seq
Prediction-Evidence microRNA.org//PITA//Targetscan
Support Database ViRBase

References:


PMID 30605755 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line A549 cells Interactor2 expression Upregulation
Description Table 1. Relationships between 8 miRNAs and inversely correlated 13 target genes selected in RT-qPCR.

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