Basic Information:

  VIRBase ID:  

HHID00092717

  Virus:  

Influenza A virus (H1N1)

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-223-3p:  MIMAT0000665          Ppp2cb:  NM_017374     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-223-3p	Ppp2cb
miRBase Accession/Entrez ID	MIMAT0000665	19053
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	AI115466//D8Ertd766//D8Ertd766e//PP//PP2Ac

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Ppp2cb	chr8:33599947-33599948(+) m6A CDS       25683224//25412662//25569111//22608085 chr8:33619274-33619275(+) m6A 3'UTR       24981863//26404942 chr8:33619326-33619327(+) m6A 3'UTR       25683224//24981863//25569111//26404942 chr8:33619337-33619338(+) m6A 3'UTR       25683224//24981863//25569111//26404942 chr8:33619381-33619382(+) m6A 3'UTR       25683224//24981863//25569111//26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-223-3p	Exosome Serum     28160157 Exosome B6 BMDCs     22031862 Exosome Bone marrow-derived macrophages     25159140 Extracellular vesicle Dendritic cells|T cells     22821563 Mitochondrion Hippocampus neuron|Liver tissue     27396686 Mitochondrion Liver tissue     20733615 Mitochondrion Hippocampus     25562527
	Ppp2cb	Synapse Brain tissue     18539120

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-223-3p
Interactor2: Ppp2cb

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	20071585	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	MDCK cells	Interactor2 expression	None
Description	In addition, miR-223 also repressed the expression of crucial intermediate molecules in these pathways, such as PI3K, PP2A, and PKA (Fig.5).